49ers at Cardinals: December 26, 2020 Odds and Early Picks

Written by on December 22, 2020

The San Francisco 49ers (5-9) are an underdog by 4.5 points as they aim to halt a three-game skid in a matchup with the Arizona Cardinals (8-6) on Saturday, December 26, 2020 at State Farm Stadium. The point total is set at 49.0 for the game.

Game Info

  • Game Day: Saturday, December 26, 2020
  • Game Time: 4:30 PM ET
  • TV Channel: Amazon Prime Video
  • Location: Glendale, AZ
  • Stadium: State Farm Stadium
Place a bet on the Cardinals or the 49ers in their Week 16 matchup.

Betting Information

Cardinals vs 49ers Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Cardinals -4.5 -110 -110 49.0 -110 -110 N/A N/A

Cardinals Betting Insights

  • Arizona has a 7-7 record against the spread.
  • The Cardinals are 3-2 ATS when favored by at least 4.5 points.
  • Arizona’s games have gone under the point total in eight out of 14 opportunities this season (57.1%).
  • The Cardinals average points scored this season (27.9) and the 49ers points allowed (25.1) are within 2.8 points of each other.
  • In games where Arizona score at least 27.9 points this season, they are 6-2 overall and 5-3 against the spread.
  • When the San Francisco defense allows 25.1 points or fewer this year, the 49ers have accumulated a 5-3 overall record and a 5-3 record against the spread.
Bet on the Cardinals to win the Super Bowl.

49ers Betting Insights

  • San Francisco has put together a losing 5-9 record against the spread this season.
  • The 49ers have a losing ATS record of 1-3 when playing as at least 4.5-point underdogs.
  • San Francisco’s games have gone over the point total in seven out of 14 opportunities this season (50%).
  • The 49ers average points scored this season (23.8) and the Cardinals points allowed (23.5) are within 0.3 points of each other.
  • In games where San Francisco scores at least 23.8 points this season, they are 4-3 overall and 4-3 against the spread.
  • Arizona is 5-1 overall and 5-1 against the spread this season in games where they allow fewer than 23.5 points.
Bet on the 49ers to win the Super Bowl.

Computer Picks

Computer picks for Cardinals vs 49ers
ATS Over/Under Score Prediction
Cardinals (-4.5) Over (49) Cardinals 29 49ers 21

Total Facts

  • In 57.1% of their games this year (eight of 14 chances), the Cardinals and their opponents have put up more than this matchup’s point total of 49.0 points.
  • In five of 14 games (35.7%) this year, San Francisco and its opponents have combined to score at least 49.0 points.
  • The Cardinals and the 49ers combine to average 2.7 more points per game than the over/under of 49.0 set for this matchup.
  • The Cardinals and the 49ers have seen their opponents average a combined 0.4 fewer points per game than the point total of 49.0 set for this outing.
  • The average point total for Cardinals games this season is 2.4 more points than the over/under of 49.0 in this matchup.
  • The average total in 49ers games this year is 0.1 fewer points than the point total of 49.0 in this outing.
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Cardinals vs 49ers: Last 5 Meetings

Arizona has an edge against San Francisco over the last five matchups between these two squads, putting together a 3-2 record in those games. The Cardinals are 2-1 against the spread in those games against the 49ers. Arizona has had the upper hand scoring in those five matchups, scoring 121 points while San Francisco notched 117.

Cardinals vs 49ers: Last Five Meetings
Date Favorite Home Team Spread Total Favorite Moneyline Underdog Moneyline Total Yards Result
9/13/2020 49ers 49ers -6.50 48.00 -295 +255 404-366 ARI 24-20 ARI
11/17/2019 49ers 49ers -9.5 44 -455 +370 442-266 SF 36-26 SF
10/31/2019 49ers Cardinals -10.5 43.5 -500 +420 411-357 SF 28-25 SF
10/28/2018 N/A Cardinals N/A N/A N/A N/A 321-267 ARI 18-15 ARI
10/7/2018 N/A 49ers N/A N/A N/A N/A 447-220 SF 28-18 ARI

Betting Insights: Last Three Games (Both Teams)

  • Arizona is 2-1 against the spread and 2-1 straight up over their last three contests.
  • Arizona has hit the over two times in their last three games.
  • The Cardinals and their opponents have combined to score an average of 52.7 points in their last three games, 3.7 more than the 49.0 over/under in this matchup.
  • San Francisco has struggled to cover, going 0-3 against the spread and 0-3 straight up over the last three contests.
  • San Francisco has gone over the total two times in their last three outcomes.
  • The 49ers have averaged a total of 56.7 combined points in their last three games, 7.7 greater than this matchup’s over/under of 49.0.

Injury Report

Cardinals: CB Johnathan Joseph: Out (Shoulder), DE Corey Peters: Out (Knee), OLB Chandler Jones: Out (Biceps), G Justin Pugh: Questionable (Calf), CB Robert Alford: Out (Torn Pectoral/illness), DE Josh Mauro: Questionable (Hamstring), NT Jordan Phillips: Out (Hamstring), TE Maxx Williams: Questionable (Ankle), K Zane Gonzalez: Out (Back), OLB Isaiah Irving: Out (Back), OLB Kylie Fitts: Questionable (Hamstring), ILB Dennis Gardeck: Questionable (Undisclosed), C Lamont Gaillard: Questionable (Undisclosed), SS Jalen Thompson: Questionable (Ankle)

49ers: G Tom Compton: Out (Concussion), ILB Kiko Alonso: Questionable (Knee), DE Dion Jordan: Questionable (Knee), CB Jamar Taylor: Out (Knee (acl)), DE Ziggy Ansah: Out (Biceps), C Ben Garland: Out (Calf), QB Jimmy Garoppolo: Out (Ankle), DE Dee Ford: Out (Back), DB Jason Verrett: Questionable (Illness), C Weston Richburg: Out (Kneecap), FS Jimmie Ward: Questionable (Concussion), SS Jaquiski Tartt: Out (Toe), C Hroniss Grasu: Questionable (Knee), RB Raheem Mostert: Questionable (Ankle), DE Ronald Blair III: Out (Knee), DT Solomon Thomas: Out (Knee (acl)), TE George Kittle: Questionable (Foot), QB Nick Mullens: Questionable (Elbow), WR Chris Thompson: Out (Undisclosed), FS Tarvarius Moore: Questionable (Ankle), WR Richie James Jr.: Questionable (Ankle), RB Jeff Wilson Jr.: Questionable (Ankle), DE Nick Bosa: Out (Acl), WR Jalen Hurd: Out (Knee), WR Deebo Samuel: Out (Hamstring), CB Ken Webster: Out (Hamstring), WR Shawn Poindexter: Out (Undisclosed), RB Austin Walter: Out (Illness), RB JaMycal Hasty: Out (Collarbone), OL Colton McKivitz: Out (Illness), TE Charlie Woerner: Out (Illness)

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