Oddsmakers project a tight game when the Buffalo Bills (8-3) take on the San Francisco 49ers (5-6) as just 2.5-point favorites on Monday, December 7, 2020. An over/under of 48.5 is set for the game.
Game Info
- Game Day: Monday, December 7, 2020
- Game Time: 8:15 PM ET
- TV Channel: ESPN
- Location: Glendale, AZ
- Stadium: State Farm Stadium
Betting Information
Favorite | Spread | Favorite Spread Odds | Underdog Spread Odds | Total | Over Total Odds | Under Total Odds | Favorite Moneyline | Underdog Moneyline |
---|---|---|---|---|---|---|---|---|
Bills | -2.5 | -125 | 105 | 48.5 | -110 | -110 | N/A | N/A |
Bills Betting Insights
- Most of Buffalo’s games this year — eight out of 11 — have hit the over (72.7%).
- Buffalo is 6-5 against the spread.
- The Bills are just 3-4 ATS when playing as at least 2.5-point favorites.
- The Bills have put an average of 27.2 points per game on the scoreboard this season, 4.1 more than the 23.1 the 49ers have surrendered in each contest.
- When they meet or outpace their scoring average this season, Buffalo is 4-1 and 4-1 against the spread.
- San Francisco is 5-0 overall and 5-0 against the spread this season in games where they allow fewer than 23.1 points.
49ers Betting Insights
- Most of San Francisco’s games this year — six out of 11 — have failed to go over the point total (54.5%).
- San Francisco has put together a losing 5-6 record against the spread this season.
- The 49ers have a losing ATS record of 2-3 when playing as at least 2.5-point underdogs.
- The 49ers average points scored this season (23.7) and the Bills points allowed (25.6) are within 1.9 points of each other.
- In games where San Francisco scores at least 23.7 points this season, they are 4-1 overall and 4-1 against the spread.
- When Buffalo allows opposing offenses to put 25.6 points or fewer on the scoreboard this year, they are 5-0 overall and 3-2 against the spread.
Computer Picks
ATS | Over/Under | Score Prediction |
---|---|---|
49ers (+2.5) | Over (48.5) | 49ers 26 Bills 24 |
Total Facts
- The Bills and their opponents have scored at least 48.5 points — this matchup’s point total — in six of 11 games (54.5%) this season.
- San Francisco and its opponents have combined to score at least 48.5 points in 27.3% of their matchups this season (three of 11 chances).
- The Bills and the 49ers combine to average 2.4 more points per game than the total of 48.5 set for this game.
- Opponents of these teams have averaged a combined 48.7 points per game, 0.2 more than the over/under for this game.
- The average total the Bills have had set in matchups this year is 4.3 more points than this outing’s point total.
- The average point total for the 49ers this season is 1.7 points lower than this game’s over/under.
Bills vs 49ers: Last 5 Meetings
San Francisco has an edge against Buffalo in the last five meetings between these two squads, putting together a 3-2 record in those games. San Francisco has had the scoring advantage in those five matchups, recording 113 points while Buffalo scored 92.
Date | Home Team | Total Yards | Result |
---|---|---|---|
10/16/2016 | Bills | 492-300 BUF | 45-16 BUF |
10/7/2012 | 49ers | 621-204 SF | 45-3 SF |
11/30/2008 | Bills | – | 10-3 SF |
12/26/2004 | 49ers | – | 41-7 BUF |
12/2/2001 | 49ers | – | 35-0 SF |
Betting Insights: Last Three Games (Both Teams)
- The Bills and their opponents have combined to score an average of 61.3 points in their last three games, 12.8 more than the 48.5 over/under in this matchup.
- Buffalo is 3-0 against the spread and 2-1 straight up over the last three contests.
- Buffalo has hit the over two times in the last three contests.
- The 49ers have averaged a total of 44.7 combined points in their last three games, 3.8 fewer than this matchup’s over/under of 48.5.
- San Francisco is just 1-2 against the spread and 1-2 straight up over their last three contests.
- San Francisco has gone under the total two times in their last three games.
Injury Report
Bills: No Injuries Listed
49ers: No Injuries Listed

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