Some shocking results in a wild Week 1 around the NFL… and yet everything remains the same in that the New England Patriots still look like the class of the league. And now Tom Brady gets to add Antonio Brown! Here’s a quick look at each Week 2 matchup with NFL odds and a pick ATS.
2019 NFL Week 2 Odds, Overview & Predictions
2019 NFL Week 2 Over/Under Betting Picks
Tampa Bay Buccaneers at Carolina Panthers
- NFL Week 2 Odds: Panthers -6.5
Matchup of former Heisman Trophy-winning quarterbacks who each won a national championship in college as well. Of course, we are talking about Tampa Bay’s Jameis Winston and Carolina’s Cam Newton. Neither played well in a Week 1 loss. The team split last year, each winning at home. Pick: Panthers.
San Francisco at Cincinnati
- NFL Week 2 Odds: PK
Each team could be missing its running back here in San Francisco’s Tevin Coleman and Cincinnati’s Joe Mixon. Each suffered an ankle injury in Week 1 with Coleman’s potentially serious. The Niners won in Tampa while the Bengals lost in Seattle. Cincy already is without top receiver AJ Green due to injury. Pick: Bengals.
LA Chargers at Detroit Lions
- NFL Week 2 Odds: Chargers -2.5
The Lions “lost” 27-27 in Arizona on Sunday, blowing a 24-6 fourth-quarter lead. No excuse for that against a rookie quarterback. The Chargers didn’t miss Pro Bowl running back Melvin Gordon too much in Week 1 as they were overtime winners behind Austin Ekeler. Gordon’s primary replacement had three touchdowns, including the winner. Pick: Lions.
Minnesota Vikings at Green Bay Packers
- NFL Week 2 Odds: Packers -2.5
One of these teams will have sole possession of first place in the NFC North (unless they tie) as both won in Week 1. Green Bay on extra rest after an upset in Chicago last Thursday, while Minnesota looked terrific Sunday in a dominant effort vs. Atlanta. Pick: Packers.
Indianapolis Colts at Tennessee Titans
- NFL Week 2 Odds: Titans -3
Former Colts quarterback Andrew Luck was 11-0 in his career against the Titans so they probably are thrilled they don’t have to see him now. Indy was an overtime loser at the Chargers in Week 1, while Tennessee had a shocking blowout win at Cleveland. Pick: Titans.
New England Patriots at Miami Dolphins
- NFL Week 2 Odds: Patriots -18
Biggest spread of the early season and could be the biggest we see all year. New England will have the debut of Antonio Brown after he signed over the weekend. Scary to think that only makes the Pats better after what they did to Pittsburgh in Week 1. Miami was flat-out embarrassed 59-10 by Baltimore and probably wouldn’t beat Clemson or Alabama. We think they cover that huge number, though. Pick: Dolphins.
Buffalo Bills at NY Giants
- NFL Week 2 Odds: Bills -2
The Giants weren’t all that competitive in Week 1 loss in Dallas and it’s only a matter of time before they switch to rookie quarterback Daniel Jones. The Bills committed four turnovers and were down 16-0 late in the third quarter of Week 1 and the Jets and yet still won 17-16. Pick: Giants.
Seattle Seahawks at Pittsburgh Steelers
- NFL Week 2 Odds: Steelers -3.5
The Steelers looked absolutely overmatched in Sunday night’s blowout loss in New England. Think the Steelers miss Antonio Brown and Le’Veon Bell now? Seattle was rather sloppy but managed to escape at home vs. Cincinnati. Pick: Steelers.
Dallas at Washington (-5.5): Washington outplayed Philadelphia for a half on Sunday but it unfortunately for the Redskins was the first half as Philly rallied to win. The Cowboys had little trouble with the Giants as Dak Prescott had a monster game. Pick: Cowboys.
Arizona Cardinals at Baltimore Ravens (-13.5)
- NFL Week 2 Odds: Ravens -13.5
Another matchup of Heisman Trophy-winning quarterbacks in Arizona rookie Lamar Jackson and Ravens’ second-year QB Lamar Jackson. He had the game of his pro life Sunday as the Ravens set a franchise-record with 59 points in trashing Miami. Pick: Cardinals.
Jacksonville Jaguars at Houston Texans
- NFL Week 2 Odds: Texans -9.5
The Jaguars’ season already might be wrecked as they lost starting quarterback Nick Foles to a broken clavicle in a Week 1 loss to Kansas City and lost the game.

Rookie Gardner Minshew takes over. Short week for Houston after visiting New Orleans on Monday. Pick Texans.
Kansas City Chiefs at Oakland Raiders
- NFL Week 2 Odds: Raiders -9.5
Short week for Oakland which hosted Denver on Monday night and of course never even got to see Antonio Brown play a single snap for the team despite giving up two draft picks in trade. The Chiefs routed the Jags on Sunday but lost top WR Tyreek Hill for a while to an injury. Pick: Raiders.
Chicago Bears at Denver Broncos
- NFL Week 2 Odds: PK
The Bears were awesome on defense but putrid on offense last Thursday in a 10-3 home upset loss to Green Bay. Now they go up against their former defensive coordinator in new Broncos head coach Vic Fangio. Pick: Bears.
New Orleans Saints at LA Rams
- NFL Week 2 Odds: Rams -3
Rematch of last season’s NFC title game won by the Rams in New Orleans because of a missed pass interference call late in regulation. Saints should have won that game. They are on a short week after hosting Houston on Monday. Pick: Rams.
Philadelphia Eagles at Atlanta Falcons
- NFL Week 2 Odds: Eagles -1
Eagles have won the past two in this series in a low-scoring affair thanks to a late goal-line stand. Philly rallied to beat Washington in Week 1, while Arizona was pushed around at Minnesota. Pick: Eagles.
Cleveland Browns at NY Jets
- NFL Week 2 Odds: Jets -2.5
New Browns receiver Odell Beckham Jr. returns to the New York City are. Both these teams faceplanted in Week 1 in losses to the Titans and Bills, respectively. Pick: Browns.