Winning Picks & Predictions for Week 1 of the 2021 NFL Season

Winning Picks & Predictions for Week 1 of the 2021 NFL Season

We are now just a few days away from the opening preseason game of the NFL season. From this point forward, we are going to have football every Sunday until February, so it’s the perfect time to start looking ahead. Let’s start with Week 1 of the regular season and some picks that we like, keeping in mind that NFL odds and picks could change depending on how teams look at the end of the preseason.

NFL Week 1 Full Game Winning Picks and Predictions

Dallas Cowboys at Tampa Bay Buccaneers – The Buccaneers have covered the spread in each of their last 4 home games, so let’s take them at -6 ½.

Philadelphia Eagles at Atlanta Falcons – With changes to both teams, it’s tough to know what to expect. I am leaning towards the UNDER 48 here.

Pittsburgh Steelers at Buffalo Bills – Two very good defenses clash here. 5 of their last 6 meetings have gone UNDER, so let’s take that again.

Minnesota Vikings at Cincinnati Bengals – In this matchup, the favorite has covered 4 in a row, so let’s take the Vikings -3.

San Francisco 49ers at Detroit Lions – The 49ers have covered the spread in 7 of their last 10 Week 1 games. Let’s go with the 49ers at -7 ½.

Arizona Cardinals at Tennessee Titans – The Cardinals are 8-3-2 ATS in their last 13 games as a road dog. I’m taking them at +3.

Seattle Seahawks at Indianapolis Colts – It looks as though this one is off the board for now as we wait to see who will start for the Colts now that Carson Wentz is injured.

LA Chargers at Washington Football Team – Washington has seen 9 of their last 10 games played on grass go UNDER. Looks like a solid trend.

New York Jets at Carolina Panthers – In their last 4 meetings, the favorite has going 3-0-1 ATS, so let’s take the Panthers at -4.

Jacksonville Jaguars at Houston Texans – With the DeShaun Watson situation still up in the air, and the road team 13-6-1 ATS in the last 20, let’s take the Jags -3.

Cleveland Browns at Kansas City Chiefs – While I like the Chiefs to win here, the Browns have covered in 4 of the last 5 versus KC.

Miami Dolphins at New England Patriots – The Dolphins have only covered once in their last 9 visits to Foxboro, so let’s take the Patriots -2 ½.

Green Bay Packers at New Orleans Saints – The favorite has covered in 6 of the last 8 meetings between these two, so that would mean the Saints ATS here.

Denver Broncos at New York Giants – The Broncos have covered the spread in 4 of their last 5 games versus the Giants, so let’s take them again here.

Chicago Bears at LA Rams – A pair of teams with new QB’s. The UNDER has hit in 6 of the last 8 between these two.

Baltimore Ravens at Las Vegas Raiders – The Ravens offense is great, but the UNDER has hit in 6 of Raven’s last 7 games on the road.


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