College Football Week 12 Betting Odds & SU Picks

Will Lamar Jackson and the College Football Week 12 betting odds favorite Louisville Cardinals make minced-meat out of a Syracuse defense that just got blown out of the water this past weekend? Can the now, unranked Iowa State Cyclones finish with a flourish after pretty much, going way beyond their expectations all season long before struggling recently? Last but not least, can the Iowa Hawkeyes hold off a Purdue team that has had a really good season in Year 1 of their latest rebuilding plan? If you’re looking for answers with Week 12 of the 2017 college football season quickly approaching, then I’ve got the answers you need. Now, keep in mind the latest NCAAF betting lines and let’s get down to business.

College Football Week 12 Betting Odds & SU Picks

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Top College Football Week 12 Betting Picks & Expert Predictions

Syracuse (4-6) at Louisville (6-4)

• When: Saturday, November 18, 3:30 PM ET
• Where: Papa John’s Cardinal Stadium, Louisville, Kentucky
• College Football Week 12 Betting Odds: Louisville -13

It’s not that Syracuse has lost three straight that bothers me. It’s how the Orange lost on Saturday. Syracuse looked to me like they flat-out quit in their completely pitiful 64-43 home loss against Wake Forest this past weekend while giving up 24 unanswered points in the fourth quarter. Syracuse was outscored 40-5 over the final two quarters and just looks like they’re ready for this seaso0n to be over with. While Louisville has been a huge disappointment for me this season, they did look good in their 38-21 beatdown of Virginia on Saturday and have scored at least 31 points in each of their last four games. Not only have the Orange gone 1-5 ATS in their last six meetings against Louisville, but the favorite in this ACC rivalry is 4-1 ATS in the last five meetings. More importantly, Lamar Jackson is still a monster dual-threat superstar and one of the most difficult players in the country to defend against. Louisville wins and covers the spread!

Latest College Football Week 12 Betting Trends

• Syracuse 2-5 SU in its last 7 games
• Syracuse is 0-5 SU in its last 5 games on the road
• Cardinals are 17-8 SU in their last 25 games
• Cardinals are 13-4 SU in their last 17 games at home
• Syracuse is 1-6 SU in its last 7 games when playing Louisville

Pick: Louisville -13

Iowa State (6-4) at Baylor (1-9)

• When: Saturday, November 18, 12:00 PM ET
• Where: McLane Stadium, Waco, Texas
• College Football Week 12 Betting Odds: Iowa State -9.5

I don’t know how else to say it, but Baylor is in big trouble against a now, unranked – and likely ticked off – Iowa State team that has suffered a pair of close losses the last two weeks to see their big-time bowl games take a significant hit. Iowa State has one of the best defenses in the nation and they’re probably looking to take out their frustration on lowly Baylor after giving up a whopping 49 points against Oklahoma State this past weekend. Baylor has just one win this season and it came against a Kansas Jayhawks team that looks unfit to be playing at the D-I level right about now. The Cyclones are a nearly unblemished 5-0-1 ATS in their last 6 conference games, a perfect 8-0 ATS in their last 8 games after allowing more than 40 points in their previous game and 5-1 ATS in their last 6 games following a straight up loss. Baylor is 10-22 ATS in their last 32 games following a double-digit loss at home and 1-6 ATS in their last 7 games in the month of November. Personally, I think this matchup is as close to a lock as it gets!

Latest College Football Week 12 Betting Trends

• Cyclones are 4-2 SU in their last 6 games
• Cyclones are 4-1 SU in their last 5 games on the road
• Bears are 1-9 SU in their last 10 games
• Bears are 0-5 SU in their last 5 games at home
• Baylor is 5-1 SU in its last 6 games when playing Iowa State

Pick: Iowa State -9.5

Purdue (4-6) at Iowa (6-4)

• When: Saturday, November 18, 12:00 PM ET
• Where: Kinnick Stadium, Iowa City, Iowa
• College Football Week 12 Betting Odds: Iowa -8.5

While I love the job that Jeff Brohm has done in his first year at Purdue, he’s still in the very beginning stages of a rebuilding mode that will take a couple of seasons to get where he really wants to go. Right now, the Iowa Hawkeyes are looking to finish off what has been a very solid season. Despite ending up on the wrong side of a humbling 38-14 loss against No. 5 Wisconsin this past weekend, Iowa has played some really good football recently and absolutely blew No. 8 Ohio State out of the water in its 55-24 Week 10 stunner two weeks ago. Purdue has dropped four of five as it winds down the regular season in search of a six-win season and accompanying bowl bid. I know the Boilermakers have gone 10-2-2 ATS in their last 14 road games vs. a team with a winning home record, but Iowa is a near-perfect 3-0-1 ATS in their last 4 home games and impressive 4-1 ATS in their last 5 games in the month of November. Iowa wins and covers the chalk!

Latest College Football Week 12 Betting Trends

• Boilermakers are 1-4 SU in their last 5 games
• Boilermakers are 2-15 SU in their last 17 games on the road
• Hawkeyes are 5-1 SU in their last 6 games at home
• Hawkeyes are 6-1 SU in their last 7 games when playing Purdue

Pick: Iowa -8.5