Must Bet Matches for Week 1 of the 2021 NCAAF Season

Must Bet Matches for Week 1 of the 2021 NCAAF Season

College Football Week 1 starts on Wednesday, Sep. 1 and runs through Monday, Sep. 6. Sunday’s Florida State versus Notre Dame contest and Monday’s Mississippi versus Louisville match made our list of must bet college football games. Our first game happens on Friday, Sep. 3, when Duke travels to Charlotte. Check out NCAAF odds, analysis, and free picks for must bet matchups in College Football Week 1. 

College Football Week 1 Games to Definitely Bet On

Duke vs Charlotte +6 ½ 

  • When: Friday, Sep. 3

Both teams are loaded with juniors and seniors. But there are differences. Duke won a couple of games last season. Charlotte also won 2, but the 49ers played 6 total. Don’t be surprised if Charlotte wins this straight up.  

College Football Week 1 Pick: Charlotte 

Michigan State vs Northwestern -3

  • When: Friday, Sep. 3

Michigan State’s program is a mess. So even though Northwestern must replace players on offense and most of their defense, the Wildcats should cover. Sparty could be one of the worst teams in the Big Ten this season.  

College Football Week 1 Pick: Northwestern 

Stanford +115 vs Kansas State

  • When: Saturday, Sep. 4

We’re playing the moneyline. Kansas State is a solid Big 12 program. But Stanford coach David Shaw will start senior Jack West. Like so many other Cardinal quarterbacks, West has spent most of his college career learning Shaw’s system. When Shaw has an experienced quarterback to play behind what’s always a top offensive line, Stanford rocks.  

College Football Week 1 Pick: Stanford  

West Virginia -3 vs Maryland

  • When: Saturday, Sep. 4

For the Terps, everything rests on Tua’s younger brother, Taulia Tagovailoa. If the offensive line can protect the junior, Maryland will be a decent team. But although Tagovailoa has the chance to have a good season, he’ll fail versus the Mountaineers’ defense. West Virginia’s defense ranked ninth in passing yards and fifth in total yards allowed per game. Most of those defenders return.   

College Football Week 1 Pick: West Virginia  

Miami OH vs Cincinnati -23

  • When: Saturday, Sep. 4

The Bearcats have a real shot to be the first team from the American Athletic Conference to grab a College Football Playoff bid. Cincinnati lost few players from 2020’s undefeated regular season squad. Cincy easily covers the big spread versus an overmatched Redhawks team.

College Football Week 1 Pick: Cincinnati 

Louisiana Tech +23 ½ vs Mississippi State

  • When: Saturday, Sep. 4

The thinking is that Mike Leach’s Mississippi State team improves this season because his players will have a better grasp of the offense. The problem is that coaches going from other conferences to the SEC almost never succeed. When it comes to this game, there’s a chance LA Tech has more overall talent than Miss State. Taking the points. 

College Football Week 1 Pick: Louisiana Tech  

Oregon State vs Purdue -7

  • When: Saturday, Sep. 4

Oregon State should be a bad team. The Beavers won’t be the worst team in the Pac-12. That distinction will go to the Arizona Wildcats. But Oregon State will find it difficult to keep it close against a decent Purdue team on the road. Boilermakers cover. 

College Football Week 1 Pick: Purdue  

Syracuse vs Ohio +105

  • When: Saturday, Sep. 4

Here’s another moneyline play. Syracuse won a single game last season. Ohio won 2-of-3 in 2020. The Bobcats’ defense is loaded with juniors and seniors. Ohio should be the favorite in this. Because this happens in the Bobcats’ stadium, they’re the SU play. 

College Football Week 1 Pick: Ohio  

Notre Dame vs Florida State +7 ½ 

  • When: Sunday, Sep. 5

In his first season as head coach of the Florida State Seminoles, Mike Norvell went 3-6. The former HC at Memphis recruited well and will now send those recruits to the field. It won’t lead to an unbelievable season, but FSU could grab a bowl bid. They could also keep this closer than the 7 ½ points. 

College Football Week 1 Pick: Florida State  

Louisville vs Ole Miss -9 ½ 

  • When: Monday, Sep. 6

Mississippi has no excuses. Lane Kiffin’s squad should rout the Louisville Cardinals. Rebels’ starting quarterback Matt Corral is a legit Heisman Trophy contender and the defense will be much improved. Kiffin thinks Ole Miss can challenge Alabama, Auburn, LSU, and Texas A&M in the loaded SEC West. If so, the Rebels should have no trouble covering versus Louisville.   

College Football Week 1 Pick: Ole Miss


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