NFL 2021-22 Season: Week 1 Betting Picks & Predictions

NFL 2021-22 Season: Week 1 Betting Picks & Predictions

We are in the way too early phase to start making picks for the NFL season, but how awful would it be if we didn’t try at all? I am going to take a look at all the games in Week 1 to see if I can pick a few winners. While all the odds are up for the games, I am strictly going to stick with straight up picks at this time. We will get into more detail with point spread and O/U as the season gets closer. Let’s get right to the picks so you can get all set to bet against their NFL odds.

NFL Week 1 Picks – Early Predictions for Every Game

Dallas Cowboys at Tampa Bay Buccaneers – The Thursday night game on Week 1 will see the champs hoist their banner and kick things off against the Cowboys. I’m sticking with the Buccaneers at home.

Philadelphia Eagles at Atlanta Falcons – I’m not really sure what to expect from either of these teams this season, so this is tough. I am taking Atlanta to win a close one.

Pittsburgh Steelers at Buffalo Bills – The Bills come into the early season as one of the early favorites to win the Super Bowl, and while this is a tough start, I think they open the season with a win.

Minnesota Vikings at Cincinnati Bengals – It is going to be fun to see Joe Burrow back from injury, but I still think this is going to be a long season for the Bengals. I’m on Minnesota here.

San Francisco 49ers at Detroit Lions – The 49ers may still have some indecision at the QB spot, but they are miles ahead of Detroit and should get off to a winning start.

Arizona Cardinals at Tennessee Titans – I am looking at the Cardinals as a definite dark horse pick this season, but this is a tough opener. I have to go with the Titans at home.

Seattle Seahawks at Indianapolis Colts – The Colts look like a team ready to challenge in the AFC, but is Carson Wentz the man to lead them? I have Indy winning a tight one.

LA Chargers at Washington Football Team – This is another tough one, but if the Washington D is anything like it was last year, they might surprise a few teams. I’m taking them as a slight underdog.

New York Jets at Carolina Panthers – A pair of different QBs for each of these teams from last season. I have a little more faith in the Panthers here.

Jacksonville Jaguars at Houston Texans – No real word on the DeShaun Watson situation in Houston, which has me leaning towards the Jags in Week 1.

Cleveland Browns at Kansas City Chiefs – Two teams expected to be in the race to represent the AFC in the Super Bowl meet in Week 1. Gotta go with the Chiefs at Arrowhead.

Miami Dolphins at New England Patriots – This is another matchup that is tough to predict. I expect a close one, but I like the Patriots to eke out the win.

Green Bay Packers at New Orleans Saints – UGH!! I’m not really sure what to do here given the current Aaron Rodgers situation. Leaning towards the Saints, but that might change.

Denver Broncos at New York Giants – This is a bout as close to a pick ‘em play as it gets. I am taking a shot with the slight underdog and going with the Giants.

Chicago Bears at LA Rams – For me, the Rams look like a legitimate threat this season, which is why I have them opening with a win over the Bears.

Baltimore Ravens at Las Vegas Raiders – Speaking of threats, we also need to mention the Ravens. I think they open with a comfortable win on the road.


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