Once the NFL schedule was set, everyone was anxious for Week 1! Although we still have a couple of months to wait, the betting public has already been putting money down for their Week 1 bets. We’ll have some interesting games in the opening week of the 2021-22 NFL season. Let’s take a look at some games where we think you can turn a little bit of cash into a lot of money. With that in mind, let’s jump right into action so you can plan your bets against their NFL odds.
2021 NFL Regular Season – Week 1 Matches To Wager On & Cash In
Jacksonville Jaguars (-2.5) @ Houston Texans
Bettors normally don’t like to put money down on a rookie quarterback starting in Week 1, but this could be a rare case. We’re not really sure what to make of Jacksonville quite yet. With a rookie NFL head coach in Urban Meyer, along with a Trevor Lawrence starting under center, there could be a lot of unknowns. Many are expecting Jacksonville to be much more competitive this season, as they had a very good draft, and made some very good free-agent signings.
The one thing we do know is that the Houston Texans are going to be very bad. It’s doubtful that Deshaun Watson will play for the Texans in this game. Even with Watson, the Texans weren’t going to be very strong, but without him, it’ll be a big struggle.
This game started out with Jacksonville being favored by 1.5 points, but quickly jumped to 2.5. Even with the quick jump, we like the Jaguars to win this one by double digits. It’s not so much that Jacksonville is going to be real good, it’s the fact that Houston is going to be really bad.
San Francisco 49ers (-7.5) @ Detroit Lions
We know that the 49ers should be contending for a playoff spot in the NFC. With numerous key players coming back from injury, the Niners should be one of the top teams in the NFC. The main question surrounding this squad will be who will be the starting quarterback in Week 1? Will we see Jimmy Garoppolo, or will rookie first rounder Trey Lance get the nod? Regardless, the Niners are substantially better than the Lions. Detroit is in rebuild mode, and every game will be a struggle for them.
This line could jump even higher, so if you feel confident in taking the Niners, you better do it now before the spread jumps even more.
Chicago Bears @ Los Angeles Rams (-7)
Los Angeles made the biggest move of the offseason when they acquired quarterback Matthew Stafford from the Detroit Lions. Stafford could be the piece that the Rams have been missing. The Rams have one of the top defenses in the league, and they have some very good skill position players. Having Stafford to run Sean McVay’s offense will be huge for the Rams.
The Chicago Bears lost some key players in the offseason. Losing cornerback Kyle Fuller could prove to be very costly. Offensively, the Bears will probably have Andy Dalton under center in Week 1. Even though they drafted Justin Fields in the first round, Matt Nagy has stated that Dalton is the starter.
The Bears are an aging team, and they just aren’t good enough to keep up with the Rams in this one. Take the Rams here.