A couple of weeks ago, this Sunday’s San Francisco at Buffalo NFL game looked like one of the least appealing matchups of the 2016 season. But things have definitely changed. The Bills are on a three-game winning streak to save Coach Rex Ryan’s job and now comes the news that Colin Kaepernick will make his first start for the Niners in almost a calendar year. The Bills are solid favorites on NFL odds.
Take a Closer Look at the San Francisco at Buffalo Betting Spread, Expert Pick & TV Info
When: Sunday, Oct. 16, 1 PM ET Where: New Era Field, Buffalo TV: Fox Radio: San Francisco / Buffalo Stream Option: NFL Live Opening NFL Lines: Bills -7.5 (44.5)“I’m ready to go, hoping I can bring more to this team and try to get us a win this Sunday.” @Kaepernick7 https://t.co/rxoCbq6z9s pic.twitter.com/RVQgZeUSUB
— San Francisco 49ers (@49ers) October 12, 2016