MyBookie Writers’ NFL Week 10 Picks & Predictions: Moneyline, ATS & O/U Expert Analysis

Since 2008, D.S. Williamson has written about sports and sports handicapping.

His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to sportsbook odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

New York Giants at Chicago Bears -3.5

The Giants may have gotten their running game going in the 34–24 loss to the 49ers — and that’s an encouraging sign heading into Week 10.

The New York Giants found success on the ground, with Jaxon Dart averaging 7 yards per carry and Devin Singletary adding over 5 yards per rush.

The Chicago Bears offense remains explosive but inconsistent — especially when Caleb Williams forces throws under pressure.

After dropping 47 points last week, Chicago could be in for a regression spot here.

Take the points with New York, and consider a small play on the moneyline for the outright upset.

Writer’s Week 10 Pick: Giants +3.5 (Live Dog Value)

Giants vs Bears Betting Lines

New England Patriots at Tampa Bay Buccaneers -2.5

Drake Maye and the Patriots are due for a letdown game — and Tampa Bay’s rested roster may be the perfect opponent to deliver it.

The New England Patriots survived a 1-point win over Atlanta last week after nearly blowing a big lead.

Now, they face a Tampa Bay Buccaneers squad coming off a bye, with Baker Mayfield clicking with rookie wideout Emeka Egbuka and the defense rounding into form.

The Bucs have quietly become one of the more disciplined teams in the NFC South.

Lay the short number — Tampa should win and cover comfortably at home.

Writer’s Week 10 Pick: Buccaneers -2.5 (Rested & Ready)

Patriots vs Buccaneers Betting Lines

Pittsburgh Steelers at Los Angeles Chargers -3

It’s tempting to back the Chargers — but Pittsburgh’s defense is playing too well to ignore.

The Pittsburgh Steelers just held Jonathan Taylor to 3.3 yards per carry and picked off Daniel Jones three times in a 27–20 victory.

Meanwhile, the Los Angeles Chargers gave up 20 points to one of the league’s weakest offenses — not exactly elite defense.

Jim Harbaugh’s team may still be adjusting, and those cracks on the defensive side could be costly.

Steelers can absolutely win this straight up — grabbing the points feels like the smart side.

Writer’s Week 10 Pick: Steelers +3 (Defensive Edge)

Steelers vs Chargers Betting Lines

Philadelphia Eagles at Green Bay Packers -2.5

Here’s your NFL Week 10 moneyline play — the Eagles off a bye are primed to shock Green Bay at Lambeau.

The Green Bay Packers are coming off an ugly loss to Carolina as two-touchdown favorites, allowing 130 rushing yards and two TDs to Rico Dowdle.

That’s bad news against a Philadelphia Eagles team featuring Saquon Barkley — who’s overdue for a breakout performance.

Philly’s rested legs and physical ground game match up perfectly against Green Bay’s leaky run defense.

Back the Eagles to win straight up.

Writer’s Week 10 Pick: Eagles Moneyline (Bye-Week Boost)

Eagles vs Packers Betting Lines

D.S. Williamson’s Week 10 selections in the MyBookie Writers’ NFL Picks spotlight sharp moneyline value, defensive matchups, and situational angles for bettors targeting NFL betting odds, ATS spreads, and prop lines with real upside before kickoff.

Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny.

As well as working as a Sports freelance writer, he also writes horror fiction.

Watson is the author of Karaoke Night, Crueller, and Off The Grid.

NFL Week 10 SU Picks

Looking to kick off your Week 10 card with some reliable straight-up (SU) winners? Here are my favorite moneyline plays for this week’s slate.

In the Thursday night primetime matchup, I like the Denver Broncos to edge out the Las Vegas Raiders in a close one.

The Indianapolis Colts are coming off a tough loss to the Steelers, but I expect them to bounce back with a solid win over the Atlanta Falcons.

Finally, the matchup between the Philadelphia Eagles and Green Bay Packers should be tight — but I’m taking Philly to pull it off in the fourth quarter.

NFL Week 10 SU Picks

Broncos vs Raiders – SU Pick: Broncos
Colts vs Falcons – SU Pick: Colts
Eagles vs Packers – SU Pick: Eagles
Bet NFL Week 10 Odds

NFL Week 10 ATS Picks

Against the spread (ATS), I’m looking at lines where motivation and matchups give one side the upper hand.

The Tampa Bay Buccaneers host the New England Patriots as short 2½-point favorites, and I like Tampa to win and cover.

The San Francisco 49ers always seem to match up well against the Los Angeles Rams, so I’m backing them to keep it close and cover as +3½ underdogs.

The Seattle Seahawks are laying 7½ against the Arizona Cardinals — a number that can be tricky, but Seattle’s offense should do enough to cover at home.

NFL Week 10 ATS Picks

Buccaneers vs Patriots – ATS Pick: Buccaneers -2.5
49ers vs Rams – ATS Pick: 49ers +3.5
Seahawks vs Cardinals – ATS Pick: Seahawks -7.5
Bet NFL Week 10 Lines

NFL Week 10 O/U Picks

For totals (O/U) plays, game tempo and recent scoring trends help shape my favorite bets on the Week 10 board.

The matchup between the Houston Texans and Jacksonville Jaguars projects as a grind — I’m taking the UNDER 39½.

Two struggling offenses square off when the Cleveland Browns meet the New York Jets, making UNDER 36½ the right call.

To wrap things up, expect some fireworks when the Washington Commanders take on the Detroit Lions — I’m going OVER 49½ in this one.

NFL Week 10 O/U Picks

Texans vs Jaguars – Pick: UNDER 39.5
Browns vs Jets – Pick: UNDER 36.5
Commanders vs Lions – Pick: OVER 49.5
Bet NFL Week 10 Totals

Henry Watkins’ Week 10 card in the MyBookie Writers’ NFL Picks blends steady favorites with value totals and underdog covers — ideal for bettors building parlays or chasing early line movement before kickoff.