NFL Week 18 Lines & Predictions: This Week's Betting Winners

Finally, Week 18 has arrived, and it might be the most difficult to evaluate the entire season. Teams have different motivations as the season’s final week approaches, and it creates an interesting dynamic.

Despite this, it also generates some intriguing betting opportunities. At MyBookie, we’re eying three teams that look like shoe-ins to win their week 18 matchup so you don’t miss your chance to bet on the NFL Odds.

Who Are the Sure Winners in Week 18 of NFL Action?

Dallas Cowboys (-4) vs Washington Commanders

The Dallas Cowboys (12-4) make the list this week as they have an opportunity to not only win the NFC East but also have a shot at the number one overall seed in the NFC. They will have a lot to play for on Sunday, and Dallas is definitely up to the task.

The Cowboys boast one of the top offenses in the NFL, averaging a second-best 28.8 points, while their defense has been just as special, leading the NFL with 32 takeaways on the year.

After holding down one of the last playoff spots for several weeks in the NFC, the Commanders completely fell apart, losing their last three games while also failing to cover their last four contests. Ron Rivera benched Taylor Heinicke in favor of Carson Wentz, and the decision completely backfired, with Wentz tossing two interceptions by attempt number six.

The Cowboys are 6-2 ATS in their last eight games in Washington against the Commanders and are 10-3-1 ATS versus teams with a losing record. They should walk away winners in Week 18.

Los Angeles Rams vs Seattle Seahawks (-6.5)

The Seattle Seahawks (8-8) have not been a very good bet lately, as they have covered the spread only once in their last six attempts. Be that as it may, the Seahawks will undoubtedly play their best football on Sunday when they face the Los Angeles Rams (5-11), as Seattle is playing for a playoff spot in Week 18.

Seattle plays their best football at home with the 12th man behind them; they put that effort on display last week by collecting almost 350 yards while their defense forced three turnovers.

Los Angeles set the record for the most losses by a defending Super Bowl Champion, and that number should move to 12 in week 18. The Rams will be without their top offensive playmakers in Matthew Stafford and Cooper Kupp, and they will also be without star defender Aaron Donald.

Additionally, the Rams are just 1-6 on the road and 1-2 ATS in their last three games. The Seahawks should walk away big winners in Week 18.

Arizona Cardinals vs San Francisco 49ers (-14)

The San Francisco 49ers (12-4) host the Arizona Cardinals (4-12) at Levi Stadium in Week 18, and San Francisco is primed to walk away as sure winners. The 49ers will be fighting for the first round-bye, and this team is arguably the hottest team in football, with nine straight victories.

Kyle Shanahan has the offense rolling despite injuries to the quarterback position, while the 49ers’ defense is the top unit in the league, holding opponents to 16.5 points and just over 300 yards per game.

Arizona has had huge issues in the season, and their biggest problem has been their health at the quarterback position. The Cardinals have suffered six straight losses while their defense has conceded, getting outscored 115-97 over that span. Arizona is focusing on the upcoming draft and should give other players opportunities to make a good impression next year.

The 49ers are 4-0 ATS in their last four home games, while they are also 7-0 against NFC West teams this season. The 49ers will keep it rolling and walk away winners this week.