It’s Week 3 of the National Football League. It’s been an entertaining first two weeks of the season, and we expect nothing less from Week 3.
There are some great games on the slate, and we will break down a few.
Let’s take a look at the NFL Week 3 Against the Spread Picks.
NFL Week 3 ATS Picks | MyBookie Regular Season Preview
2023-24 NFL | 104th season of the National Football League
NFL Week 3: Thursday, September 21st – Monday, September 25th, 2023
San Francisco 49ers vs. New York Giants | Thursday Night Football
ATS: 49ers -10
Thursday, September 21st, 2023 at 8:15 PM | PRIME VIDEO
Levi’s Stadium, Santa Clara, CA
The 49ers look to be one of the best teams in the league again. Christian McCaffrey is awfully tough to take down, and if he is not getting it done, the rest of the offense is also talented.
No Saquan Barkley potentially for the Giants is horrible news. A short week, no running back, and a trip to San Francisco. None of that sounds fun.
A combination of McCaffrey, Deebo, Aiyuk, Kittle, and a sharp Purdy with no Barkley is terrible news for the road team. Bet the 49ers to win this game easily on Thursday Night Football.
NFL Week 3 ATS Pick: 49ers -10 | Bet 49ers over Giants
MyBookie Betting Lines for the Game
Buffalo Bills at Washington Commanders
ATS: Bills -6.5
Sunday, September 24th, 2023 at 1:00 PM | CBS
FedExField, Landover, MD
The Buffalo Bills got back on track in Week Two. Look for more where that came from in Week 3. Sure, the game is in Washington, but you will see many Bills fans in the house.
Buffalo is talented and will use that Week One loss to the Jets to their favor as the season progresses. Josh Allen torches the Washington defense, Buffalo plays solid defense, and the Bills win this game fairly easily.
NFL Week 3 ATS Pick: Bills -6.5 | Bet Bills over Commanders
MyBookie Betting Lines for the Game
Baltimore Ravens vs. Indianapolis Colts
ATS: Ravens -8
Sunday, September 24th, 2023 at 1:00 PM | CBS
M&T Bank Stadium, Baltimore, MD
The Baltimore Ravens are 2-0 to start the season. The win over the Bengals was an impressive one. Baltimore can do many things well and has a quarterback in Lamar Jackson, who is tough to navigate against.
For Indianapolis, keep an eye on the progress of quarterback Anthony Richardson. His two early rushing touchdowns put the Colts in a great spot, but the offense is nowhere the same without him. Whether he is in or not, the Ravens win this game by double digits.
NFL Week 3 ATS Pick: Ravens -8 | Bet Ravens over Colts
MyBookie Betting Lines for the Game
Seattle Seahawks vs. Carolina Panthers
ATS: Seahawks -6
Sunday, September 24th, 2023 at 4:05 PM | CBS
Lumen Field, Seattle, WA
The Week Two win for Geno Smith, Pete Carroll, and his Seattle Seahawks was just what the doctor ordered.
The Seahawks were on the verge of potentially starting the season 0-2, but Smith led them downfield for an overtime win. Now, the Seattle offense is back on track and will take on a Carolina team that has struggled to start the season. The Panthers are 0-2 and are having a tough time scoring.
It’s hard to imagine a scenario where the Panthers stay within a field goal in this game. Take the Seahawks -4 over the Panthers in this Sunday affair.
NFL Week 3 ATS Pick: Seahawks -6 | Bet Seahawks over Panthers
MyBookie Betting Lines for the Game
Kansas City Chiefs over Chicago Bears
ATS: Chiefs -12.5
Sunday, September 24th, 2023 at 4:25 PM | FOX
GEHA Field at Arrowhead Stadium, Kansas City, MO
While the Kansas City Chiefs are 1-1 on the season, this game has vibes as the best team in the National Football League against the worst team. Patrick Mahomes was not over-the-top impressive in Week Two, but having Travis Kelce back made things much better for the offense.
The defense was the key for the Chiefs, who kept the Jaguars off balance all day. For Chicago, staring 0-3 in the eyes and 13 straight losses is not the news they wanted.
Justin Fields shows some brilliance but then returns to being a guy who is only out there for his legs. He didn’t use his legs against Tampa, and his two late interceptions sealed the fate.
NFL Week 3 ATS Pick: Chiefs -12.5 | Bet Chiefs over Bears
MyBookie Betting Lines for the Game
NFL Week 3 Schedule
Dates: 9/20 – 9/26
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 21 | Giants at 49ers (-10) | Giants +415: 49ers -575 | 44.5 |
| Sun, Sept. 24 | Texans at Jaguars (-9.5) | Texans +350; Jaguars -480 | 43.5 |
| Sun, Sept. 24 | Saints at Packers (-2) | Saints -106; Packers -129 | 42.5 |
| Sun, Sept. 24 | Falcons at Lions (-3.5) | Falcons +142; Lions-175 | 45.5 |
| Sun, Sept. 24 | Colts at Ravens (-8) | Colts +310; Ravens -420 | 45 |
| Sun, Sept. 24 | Titans at Browns (-3) | Titans +131; Browns -161 | 39.5 |
| Sun, Sept. 24 | Chargers (-0.5) at Vikings | Chargers -110; Vikings -100 | 54 |
| Sun, Sept. 24 | Bills (-6.5) at Commanders | Bills -289; Commanders +226 | 44.5 |
| Sun, Sept. 24 | Broncos at Dolphins (-6.5) | Broncos +220; Dolphins -280 | 48 |
| Sun, Sept. 24 | Patriots (-2.5) at Jets | Patriots -145; Jets +119 | 37 |
| Sun, Sept. 24 | Panthers at Seahawks (-6) | Panthers +206; Seahawks -259 | 42 |
| Sun, Sept. 24 | Bears at Chiefs (-9.5) | Bears +330; Chiefs -410 | N/A |
| Sun, Sept. 24 | Cowboys (-12.5) at Cardinals | Cowboys -520; Cardinals +800 | 47.5 |
| Sun, Sept. 24 | Steelers at Raiders (-2.5) | Steelers +114; Raiders -139 | 43 |
| Mon, Sept. 25 | Eagles (-2) at Buccaneers | Eagles -229; Buccaneers +183 | 46 |
| Mon, Sept. 25 | Rams at Bengals (-2) | Rams +105; Bengals -128 | 43.5 |
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| Kansas City Chiefs | +480 |
| San Francisco 49ers | +520 |
| Baltimore Ravens | +930 |
| Philadelphia Eagles | +960 |
| Detroit Lions | +990 |
| Buffalo Bills | +1175 |
| Houston Texans | +1300 |
| Dallas Cowboys | +1475 |
| New York Jets | +1475 |
| Cincinnati Bengals | +1625 |
| Miami Dolphins | +2300 |
| Atlanta Falcons | +2900 |
| Los Angeles Rams | +3000 |
| Chicago Bears | +3100 |
| Green Bay Packers | +3100 |
| Los Angeles Chargers | +3200 |
| Cleveland Browns | +3900 |
| Pittsburgh Steelers | +4100 |
| Jacksonville Jaguars | +4500 |
| New Orleans Saints | +4900 |
| Minnesota Vikings | +5400 |
| Seattle Seahawks | +5800 |
| Tampa Bay Buccaneers | +6200 |
| Indianapolis Colts | +8000 |
| Las Vegas Raiders | +9000 |
| Arizona Cardinals | +11000 |
| Washington Commanders | +13000 |
| Denver Broncos | +14000 |
| New England Patriots | +14000 |
| Tennessee Titans | +16000 |
| New York Giants | +17000 |
| Carolina Panthers | +40000 |
There you go. Those are our five favorite Week 3 National Football League Against the Spread betting picks. We hope you enjoy the games and best of luck with all your betting picks for the weekend!
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