UFC Fight Night Betting: Leon Edwards vs Sean Brady Odds, Picks

Check out UFC Fight Night betting odds, analysis, and free picks for this Saturday’s Fight Night: Leon Edwards vs Sean Brady Odds. This Saturday’s UFC happens at the O2 Arena in London, England.

The main event pits former champ Leon Edwards against Sean Brady. Jan Blachowicz takes on Carlos Ulberg in a main card bout and in one of the top prelim fights, Jai Herbert throws down against Chris Padilla.

UFC Fight Night Betting: Leon Edwards vs Sean Brady Odds – Main Card

When: Saturday, March 22 at 10:00 am ET
Where: O2 Arena, London, England
TV/Streaming: ESPN+
Odds listed at time of Writing

Nathan Fletcher -114 vs Caolan Loughran -107

Prelims
UFC Fight Night Pick: Caolan Loughran

Favorite Nathan Fletcher is 9-1 overall and 7-0 via submissions. The fact he’s undefeated when the bout goes to the ground makes Fletcher a worthy chalk.

But Caolan Loughran is a solid mixed martial artist. The underdog in this is 1-2 in his last 3. But Loughran is 7-0 via TKO/KO and 2-0 via submissions.

Give the dog a chance to bite.

Marcin Tybura +101 vs Mick Parkin -123

Prelims
UFC Fight Night Pick: Mick Parkin

The odds on Tybura versus Parkin fell to -110 on both sides. Tybura has lost 2-of-3. Marcin still has winning records via TKO/KO and via submission.

Mick Parkin is 10-0 overall. Parkin is 6-0 via knockout and 1-0 via submission. Mick hasn’t fought the same level of competition that Tybura has.

Parkin is fighting so well, though, he’s impossible to go against.

Jai Herbert -109 vs Chris Padilla -112

Prelims
UFC Fight Night Pick: Chris Padilla

Herbert versus Padilla should be an excellent bout. Herbert is the chalk, but his lone win in the last 4 came in an August 2024 bout, and it came via decision.

Padilla won his first 2 UFC bouts. Chris took home a win via submission. Then he won his next bout via TKO.

Even though Herbert has much more UFC experience, Padilla is scorching. Give the dog a shot.

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UFC Fight Night Betting provided by MyBookie

Nathaniel Wood +128 vs Morgan Charriere -158

Main Card
UFC Fight Night Pick: Morgan Charriere

Wood has won 4-of-5. All 4 wins came via unanimous decision, while the lone loss was by decision against Muhammad Naimov.

Charriere has also won 4-of-5. Charriere’s lone loss came via split decision in his second UFC bout.

The favorite is 12-0 via TKO/KO and 3-1 via submission. Back the chalk to cash.

Gunnar Nelson -133 vs Kevin Holland +109

Main Card
UFC Fight Night Pick: Gunnar Nelson

Gunnar Nelson versus Kevin Holland is a bout between two exceptional veteran UFC fighters.

Holland is the slight dog because he has a single win in his last 5. However, Holland has gone against top competition like Roman Dolidze.

Nelson is on a 2-match winning streak. Not only that, but Nelson is undefeated via submission wins, going 13-0.

Gunnar is also 4-1 via TKO/KO. Here’s another on Saturday where the favorite should prevail.

Jan Blachowicz +234 vs Carlos Ulberg -300

Co-Main Event
UFC Fight Night Pick: Carlos Ulberg

It’s rare to see Blachowicz such a big time underdog. Jan has 10 losses, but he’s 9-2 both via knockout and technical knockout and submission, which tells us most losses came via decision.

Blachowicz has also fought some of the best in the division at UFC. Ah, but Jan hasn’t won since a 2022 bout.

The draw versus Magomed Ankalaev, the new light heavyweight champ, also came in 2022. The dog also hasn’t fought since 2023.

The layoff should hurt Blachowicz versus Carlos Ulberg. The fave is 12-1 overall. He’s 7-1 via TKO/KO and is on fire. Ulberg gets it done.

Leon Edwards +134 vs Sean Brady -169

Welterweight Main Event
UFC Fight Night Pick: Leon Edwards

In the main event, Leon Edwards, the former champ, is an underdog versus Sean Brady.

Edwards is taller, 6’ 2” to 5’ 10”, and has a single loss in his last 5. The defeat came against Belal Muhammed in a championship bout in 2024.

Before the loss, Edwards had beaten Kamaru Usman twice in title fights and Colby Covington once, which is why I’m surprised that Edwards is a dog.

Sean Brady has won 4-of-5. Brady’s lone loss in his last 5 also came versus Muhammed.

This should be a close bout, which means we must consider backing the mixed martial artist offering the better odds.

Leon Edwards vs Sean Brady
Jan Blachowicz vs Carlos Ulberg

Your #UFCLondon main and co-main event checking in for fight week! pic.twitter.com/6cuQQkVJ5F
— UFC Europe (@UFCEurope) March 18, 2025