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By the time Week 5 rolls around on the second Sunday in October, most teams will have figured out who they are. And bettors will have a much better idea of which teams are going to disappoint against the spread and which teams are going to surprise.

See below for NFL betting odds and analysis for all the games happening on Week 5 of the 2023 season.

NFL Week 5 Must Bet Games | MyBookie NFL Preview

NFL Week 5: October 5-9, 2023

Jacksonville Jaguars vs. Buffalo Bills

NFL Odds: Jaguars +3.5, Bills +3.5
When: Sunday, October 8, 2023, 2023 at 4:05 pm ET
Where: Tottenham Hotspur Stadium | London, England

Normally you wouldn’t take the team from Florida on the road at Buffalo, but this game has the Jaguars as the road team in London, where they are as close to a home team as anyone gets.

The ascension will continue for the Jags as Trevor Lawrence continues to grow and Calvin Ridley finds a home in Doug Pederson’s offense. They also have an improved offensive line that will begin jelling by Week 5 and better depth at running back.

Buffalo is still one of the elite teams in the AFC, but they are getting too many points for their first trip to London since 2015 and only their second-ever trip overseas. Take the points for the far more experienced Jacksonville Jaguars.

NFL Week 5 Betting | Bet Jaguars vs. Bills
MyBookie Betting Lines for the Game

Philadelphia Eagles at Los Angeles Rams

NFL Odds: Eagles -5, Rams +5
When: Sunday, October 8, 2023, 2023 at 4:05 pm ET
Where: SoFi Stadium | Inglewood, CA

Back on this side of The Pond, the last two NFC champions will meet at SoFi Stadium. With all due respect to the 2021 conference champions, the five-point spread in favor of the 2022 conference champions is not enough. The Los Angeles Rams are not good, and the Philadelphia Eagles are still great.

The Rams aren’t quite in tank mode, but there are so many pieces missing from their Super Bowl-winning team of just two seasons ago they are barely recognizable. And age and injuries are finally catching up to Matthew Stafford. Sean McVay will keep them somewhat competitive during the season, but not against great teams.

And the Eagles are great and just as dominant as the team that marched to the Super Bowl a year ago and was the last team in the NFL to take a loss in 2022.

This feels like an easy double-digit win for Philadelphia, and if you can get the Eagles for less than a touchdown, you should absolutely take it. Fly, Eagles, fly, and give those points.

NFL Week 5 Betting | Bet Eagles vs. Rams
MyBookie Betting Lines for the Game

Cincinnati Bengals at Arizona Cardinals

NFL Odds: Bengals -7.5, Cardinals +7.5
When: Sunday, October 8, 2023, 2023 at 4:05 pm ET
Where: State Farm Stadium | Glendale, AZ

In Arizona, tank mode has been in full effect since the draft, and by Week 5, it will be apparent that they are the worst team in the NFL and staring at a possible 0-17 season.

The Bengals are one of the favorites in a loaded AFC, and they will light up the Cardinals all afternoon. Arizona was 1-4 last season against the AFC, losing to the Chiefs by 23, the Patriots by 14, and the Broncos by nine. This is an even worse Arizona team, the Bengals have one of the best offenses in football, and 7.5 points isn’t nearly enough of a spread.

Give those points and take Cincinnati. The Bengals are a potential Super Bowl team. Arizona is the early favorite to run away with the first overall pick in the draft.

NFL Week 5 Betting | Bet Bengals vs. Cardinals
MyBookie Betting Lines for the Game

NFL Week 5 | 2023 Season

Dates: 10/5 – 10/9
BYE WEEK: Browns, Chargers, Seahawks, Buccaneers

Date	Spread	Moneyline	Over Under
Thurs, Oct. 5	Bears at Commanders (-1.5)	Bears +100; Commanders -120	N/A
Sun, Oct. 8	Jaguars at Bills (-3.5)	Jaguars +145; Bills -170	N/A
Sun, Oct. 8	Titans at Colts (-1)	Titans -105; Colts -115	N/A
Sun, Oct. 8	Panthers at Lions (-5)	Panthers +180; Lions -210	N/A
Sun, Oct. 8	Texans at Falcons (-3)	Texans +130; Falcons -150	N/A
Sun, Oct. 8	Giants at Dolphins (-4.5)	Giants +170; Dolphins -200	N/A
Sun, Oct. 8	Ravens (-1) at Steelers	Ravens -115; Steelers -105	N/A
Sun, Oct. 8	Saints at Patriots (-3)	Saints +130; Patriots -150	N/A
Sun, Oct. 8	Eagles (-4.5) at Rams	Eagles -200; Rams +170	N/A
Sun, Oct. 8	Bengals (-7.5) at Cardinals	Bengals -340; Cardinals +280	N/A
Sun, Oct. 8	Chiefs (-4) at Vikings	Chiefs -190; Vikings +160	N/A
Sun, Oct. 8	Jets (-1) at Broncos	Jets -115; Broncos -105	N/A
Sun, Oct. 8	Cowboys at 49ers (-2)	Cowboys +105; 49ers -125	N/A
Mon, Oct 9	Packers at Raiders	Packers +100; Raiders -120	N/A