Analyzing NFL Game Lines for Chiefs vs Panthers Week 12 Pick

As Week 12 of the 2024 NFL season approaches, bettors are eyeing the NFL game lines for the Kansas City Chiefs (9-1) vs. the Carolina Panthers (3-7) matchup, a clash between a Super Bowl contender and a rebuilding team eager for an upset at Bank of America Stadium.

Betting 2024 NFL Week 12 Pick for the Chiefs vs Panthers
NFL Week 12 Fever: Don’t Miss Out on the Betting Action

2024 NFL Season | 104th season of National League in the United States
Week 12: Thursday, November 21st – Monday, November 25th, 2024

Betting 2024 Kansas City Chiefs at Carolina Panthers | NFL Week 12 Lock

The Kansas City Chiefs (9-1) are heading to Bank of America Stadium to take on the Carolina Panthers (3-7) in Week 12.

This Sunday afternoon game will showcase two teams at different ends of the standings.

The Chiefs are aiming to bounce back from a rare loss, while the Panthers hope to extend their recent win streak to three games.

Both teams have something to prove in this game.

The Chiefs want to show they can quickly recover from their loss and maintain their top spot in the AFC.

Meanwhile, the Panthers are building confidence as they adjust to new players and strategies.

The matchup features a Super Bowl favorite against a rebuilding team hungry for an upset.

NFL Week 12: Kansas City Chiefs (9-1) at Carolina Panthers (3-7)
Sunday, November 24th, 2024 at 1:00 PM EST CBS | Bank of America Stadium, Charlotte, NC

ATS Odds: Kansas City -10.5
Money line Odds: Chiefs -676, Panthers +460
Over/Under Odds: 43

Writer’s Breakdown and Pick for the Chiefs vs Panthers Game

Betting on the Kansas City Chiefs

Kansas City comes into this game leading the AFC West and holding one of the best records in the NFL.

The Chiefs, led by Patrick Mahomes, are looking to recover after losing 30-21 to Buffalo last week. (Remember, we have NFL Week 12 Quarterback top matchups worth checking out)

That loss ended their undefeated streak and gave them a chance to refocus as they aim for another deep playoff run.

Mahomes has been steady, throwing for 2,338 yards and nine touchdowns so far this season.

Injuries could play a role for Kansas City, with key players like Isiah Pacheco and JuJu Smith-Schuster battling to return.

The Chiefs’ offense has relied on Travis Kelce and a balanced attack, but their defense has also been strong, ranking in the top half of the league.

Kansas City will need to stay disciplined and avoid turnovers to keep control of this game.

Patrick Mahomes remains their biggest weapon, capable of breaking down any defense.

Betting on the Carolina Panthers

The Panthers sit at the bottom of the NFC South but have shown signs of improvement recently.

Carolina has won two straight games and had an extra week to prepare for Kansas City.

Rookie quarterback Bryce Young is starting to find his rhythm, and the Panthers are leaning on him to build momentum.

Young has thrown for 1,785 yards and eight touchdowns this season but faces a big challenge against the Chiefs’ defense.

Carolina’s ground game will be crucial, especially with running back Jonathan Brooks expected to make his debut.

With Miles Sanders sidelined, the Panthers are relying on Chuba Hubbard and Brooks to provide a spark.

Defensively, they’ll need their secondary, led by Jaycee Horn, to limit Mahomes’ options.

The Panthers’ coaching staff will focus on playing smart and taking advantage of any mistakes by Kansas City.

Bryce Young must stay poised under pressure.

Chiefs vs Panthers Prediction Plus Winning Pick

Kansas City’s experience and offense give them a clear edge in this matchup.

The Panthers have made strides, but they’ll face a tough test against the Chiefs, who are motivated to return to their winning ways.

While the Panthers have momentum, the Chiefs’ roster is built to handle pressure and bounce back after a loss.

If Kansas City’s offense finds its rhythm early, Carolina could struggle to keep pace.

Expect the Chiefs to lean on their defense to create turnovers and seal the win.

Score Prediction: Chiefs 27, Panthers 14

NFL ATS Pick: Kansas City -10.5
NFL Total Pick: Under 43.5

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Chiefs vs Panthers Trends and Insights

Patrick Mahomes has hit the Interceptions Over in 13 of his last 20 games
Isiah Pacheco has hit the Carries Over in 8 of his last 10 games
Bryce Young has hit the TD Passes Under in 8 of his last 12 games
Miles Sanders has hit the Carries Under in 10 of his last 13 games
Chiefs have hit the 3Q Game Total Under in 13 of their last 20 games
Chiefs have covered the 4Q Spread in 13 of their last 20 games
Panthers have hit the 4Q Game Total Under in 13 of their last 17 games
Panthers have covered the 3Q Spread in 12 of their last 17 games
Chiefs are 9-1 when betting on the Moneyline
Chiefs are 5-5 when betting the Over
Panthers are 7-3 when betting the Over for +3.7 Units / 33.64% ROI
Panthers are 3-7 when betting the Under

Panthers vs. Chiefs Series History

Last meeting:
Chiefs 33, Panthers 31: November 8th, 2020: Week 9 Game – Arrowhead Stadium, Kansas City, MO

Head-to-head (includes postseason games):
Kansas City Chiefs lead series 5-2-0

I asked Jaycee Horn about opportunities for the secondary in Sunday’s upcoming game vs the #Chiefs.
•#Panthers pic.twitter.com/2tLPHR0PkK
— Sheena Quick (@Sheena_Marie3) November 21, 2024