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Liverpool versus Chelsea and Arsenal hosting Manchester United in London headline English Premier League Matchweek 21 action. Both Pool and the Blues will enter their match without top players. Arsenal must beat Man U without Gabriel Jesus. See below for Premier League Odds, analysis, and free picks for those two matches as well as four other EPL matches happening this weekend.

2022-23 EPL Games to Must Bet and Watch this Weekend (Jan. 21st – 22nd)

Liverpool -121 vs Chelsea +310

When: Saturday, Jan. 21 at 7:30 am ET

The Reds take on the Blues a game after Harvey Elliott made a stunning goal to give Liverpool a 1-0 victory over Wolverhampton in an FA Cup match. Pool is not one-hundred percent healthy, but Mohamed Salah should play.

Salah will be the difference. One of the top strikers in the Premier, Salah took a seat in the FA Cup victory. If Mohamed steps onto the pitch, watch out. The Blues are not a good road team and Eduardo Mendy is injured.

Soccer Pick: Liverpool -121

Leicester City +242 vs Brighton & Hove Albion +109

When: Saturday, Jan. 21 at 10:00 am ET

Things are so bad for Leicester that the home team is an underdog versus Brighton. Last season, LC would have been the big time chalk, possibly, even by 1.5 goals. Leicester has a win and 4 losses in their last 5.

Brighton is on a 3-match winning streak and has won 4-of-5. The home team could surprise but the road squad is playing too well to lose.

Soccer Pick: Brighton & Hove Albion

Crystal Palace +320 vs Newcastle United -111

When: Saturday, Jan. 21 at 12:30 pm ET

The road team could be very tough in this. After a couple of draws and an inexplicable FA Cup match loss to Sheffield Wednesday, Newcastle has won 2 straight in a 2-0 contest against Leicester and a 1-0 win over Fulham.

Crystal Palace had lost 3 straight. But Crystal forced a draw in their last match versus Manchester United. If there form has turned around, Palace can pull off the upset. The odds make Crystal an overlay.

Soccer Pick: Crystal Palace

Leeds United +141 vs Brentford +184

When: Sunday, Jan. 22 at 9:00 am ET

Leeds has a slight edge because they’re the home team. But although Leeds is the chalk and takes on Brentford on their pitch, the road squad deserves a long look.

Brentford has won 3-of-4. 1 of the victories was a 3-1 win over Liverpool. The road team shouldn’t offer odds anywhere close to the current line. The dog gets the nod.

Soccer Pick: Brentford

Manchester City -2.5 +139 vs Wolverhampton Wanderers +2.5 -177

When: Sunday, Jan. 22 at 9:00 am ET

Manchester City is on a 2-match losing streak. But although City isn’t at their best, the Sky Blues are tough to go against because Wolverhampton isn’t playing well.

Almost as important? The odds make Wolverhampton an underlay. Backing the Sky Blues to get it together makes sense.

Soccer Pick: Manchester City -2.5

Arsenal -114 vs Manchester United +295

When: Sunday, Jan. 22 at 11:30 am ET

On the surface, the Gunners should take this. Arsenal has an 8-point lead over both the Sky Blues and the Red Devils.

But a closer look reveals that Man United can pull off the upset win. Since parting ways with Ronaldo, United has rocked. To put matters more in their favor, Jadon Sancho should return to the pitch to help Marcus Rashford and Bruno Fernandes on the attack. United gets the call.

Soccer Pick: Manchester United

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