NFL Odds this Week Buffalo vs Detroit Lines & Picks

Super Bowl favorite Buffalo heads to Detroit on Thursday to battle the Lions in the annual early Thanksgiving Day game. The Bills are a solid -9.5 chalk to beat the hometown Lions. Will scorching Detroit play well enough to at least cover? Or will the Bills get back to their dominating ways? Check out NFL Lines, analysis, and a free pick for Bills at Lions.

NFL Week 12 Betting Preview for Buffalo Bills at Detroit

Buffalo Bills vs Detroit Lions Odds and Match Info

When: Thursday, Nov. 24 at 12:30 pm ET
Where: Ford Field, Detroit, MI
TV / Streaming: CBS / Paramount +
ATS Odds: Buffalo -9.5
Moneyline Odds: Buffalo -440 / Detroit +320
Over/Under Odds: 54.5

Why bet on Buffalo versus Detroit?

Buffalo had struggled with back-to-back losses to the Jets and Vikings. But in NFL Week 11, the Bills stepped it up against the Cleveland Browns.

Facing the Browns a -7.5 chalk, the Bills dominated Cleveland’s defense with 171 rushing yards. Buffalo beat the Browns 31-23 to cover by a half-a-point. Buffalo figures to bring momentum they gained from the win to Detroit.

Buffalo Bills Offensive Averages

Total Yards: 417.4

Passing Yards: 283.4

Rushing Yards: 134.0

Points Scored: 28.1

Turnovers: 18

Buffalo Bills Defensive Average

Total Yards: 327.4

Passing Yards: 220.8

Rushing Yards: 106.6

Points Scored: 17.4

Takeaways: 16

Why bet on Detroit versus Buffalo?

The Lions are one of the hottest teams in the NFL. Detroit has won three games straight up and against the spread. No victory was as impressive as the Lions’ 31-18 road win versus the then 7-2 New York Giants.

Detroit held the Giants to 89 rushing yards while the Lions rumbled for 160 on the ground. Detroit’s defense allowed Daniel Jones to throw for over 300 yards, but tightened in the red zone to force more field goals than touchdowns.

On Thursday, Buffalo doesn’t face the same Lions squad from earlier in the season. The NFL Week 12 Detroit Lions are a solid club on both sides of the ball.

Detroit Lions Offensive Averages

Total Yards: 366.6

Passing Yards: 233.8

Rushing Yards: 132.8

Points Scored: 25.0

Turnovers: 12

Detroit Lions Defensive Averages

Total Yards: 415.9

Passing Yards: 262.2

Rushing Yards: 153.7

Points Scored: 28.2

Takeaways: 12

Bills at Lions Relevant Trends

Bills are 6-1-1 ATS in their last 8 on field turf
Buffalo is 5-0 ATS in t heir last 5 games in week 12
Under is 5-0 in the Bills’ last 5 on the road
Lions are 4-0 ATS in their last 4 games following an SU win
Detroit is 7-2 ATS in their last 9 at home
Over is 6-0 in the Lions’ last 6 following an ATS win

Buffalo Bills at Detroit Lions Final Betting Prediction

Positive trends exist for both teams. So what we want to do is think about this game in terms of strategy. The Bills will try to use their defense to stop Detroit’s rushing attack.

It might work, but if it does, Buffalo’s secondary will struggle in the passing game. The Bills allowed Kirk Cousins to throw for 357 yards in week 10.

In their last, Browns QB Jacoby Brissett, torched the Bills for 324 passing yards and 3 TDs. Jared Goff, the Lions quarterback, is a better player than Brissett.

Goff doesn’t make a lot of mistakes, which means Buffalo’s D should be in some trouble. It’s tough to beat the Lions on Thanksgiving. Detroit will have a chance to win this straight up. Taking the points is the play to make.

NFL Week 12 Pick: Detroit Lions +9.5