In the Week 3 Thursday Night Football matchup, the New York Giants will square off against the San Francisco 49ers. Both teams enter this game fresh off Week 2 victories. The New York Giants had to stage a dramatic comeback in the closing moments of their Sunday game against Arizona to secure the win.
This victory followed a Week One blowout loss at home to the Dallas Cowboys. Currently, the Giants hold a 1-1 record, trailing the other three teams in their division by a single game.
In contrast, the San Francisco 49ers are riding high with a perfect 2-0 record, having secured road victories against the Pittsburgh Steelers and the Los Angeles Rams. Their impressive start places them at the summit of the NFL Standings and atop the NFC West division. The San Francisco 49ers are -10.5 at home, totaling 45 for this Thursday Night Football affair.
Check out the NFL odds, analysis, and free pick for New York Giants versus the San Francisco 49ers TNF game on NFL Week 3.
Giants vs 49ers Odds and Betting Prediction for the Game | MyBookie NFL Week 3 Regular Season Preview
New York Giants vs San Francisco 49ers | NFL Week 3
ATS Odds: 49ers -10.5
Money line Odds: Giants +415/ 49ers -575
Over/Under Odds: 44
Thursday, September 21st at 8:15 pm ET | PRIME VIDEO
Levi’s Stadium, Santa Clara, CA
Giants Without Top Running Back
Facing a potential 0-2 start, Daniel Jones and the New York Giants entered a crucial matchup. At halftime, something shifted, unleashing a remarkable turnaround that saw them score 31 points in the second half, ultimately clinching a victory.
Jones’s performance was pivotal, as he racked up 321 passing yards and tossed two touchdowns. His sole interception resulted from a pass deflected by Saquon Barkley early in the contest.
49ers Seeking Perfect 3-0 Start
The 49ers are full of talented players and group together to make one of the best teams in the National Football League. Christian McCaffrey continues to shine as one of the league’s most explosive offensive talents, amassing over 100 yards in each of his first two games and notching a rushing touchdown in both outings. McCaffrey’s impressive performances have thrust him into the conversation for NFL MVP honors.
But the 49ers don’t rely solely on McCaffrey; they boast a dynamic passing attack led by Deebo Samuel and Brandon Aiyuk, forming a formidable receiving duo. Aiyuk leads the team with 11 receptions and has found the end zone twice.
Brock Purdy has also showcased his talents, completing 36 of 54 passes for 426 yards in the early stages of the season. And let’s not forget the 49ers’ defense, which has been exceptional, allowing a mere 15 points per game in the first two contests, second only to the Dallas Cowboys in the NFC.
Their win against the Rams saw them force Matthew Stafford into two interceptions, highlighting the strength of this well-rounded San Francisco 49ers roster on both sides of the ball.
New York Giants vs San Francisco 49ers Final Prediction | Thursday Night Laugher Heading to San Francisco
This has the potential to be an ugly football game—a short week for a banged-up Giants team. Top running back out. A quarterback who finished strong but has only put together two solid quarters so far this season. An offense in San Francisco that is nearly impossible to slow down.
Look for a big game from McCaffrey, and Purdy is strong again. 10.5 points is a ton to cover, but if a team is going to do it – it’s the 49ers.
Bet the San Francisco 49ers -10.5 over the New York Giants in this NFL affair on Thursday Night Football!
NFL Week 3 Pick: San Francisco San Francisco 49ers -10.5 | Bet Giants vs 49ers
MyBookie Betting Lines for the Game
New York Giants Last 5
| Date | OPP | Result |
|---|---|---|
| 9/17/23 | @ ARI | W31-28 |
| 9/10/23 | vs DAL | L40-0 |
| 8/26/23 | vs NYJ | L32-24 |
| 8/18/23 | vs CAR | W21-19 |
| 8/11/23 | @ DET | L21-16 |
New York Giants Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Wan’Dale Robinson WR | Questionable | Sep 20 |
| Azeez Ojulari LB | Out | Sep 20 |
| Micah McFadden LB | Questionable | Sep 20 |
| Ben Bredeson G | Out | Sep 20 |
NFC East Standings | New York Giants
| Team | W | L | T | Strk |
|---|---|---|---|---|
| Dallas Cowboys | 2 | 0 | 0 | W2 |
| Philadelphia Eagles | 2 | 0 | 0 | W2 |
| Washington Commanders | 2 | 0 | 0 | W2 |
| New York Giants | 1 | 1 | 0 | W1 |
San Francisco 49ers Last 5
| Date | OPP | Result |
|---|---|---|
| 9/17/23 | @ LAR | W30-23 |
| 9/10/23 | @ PIT | W30-7 |
| 8/25/23 | vs LAC | L23-12 |
| 8/19/23 | vs DEN | W21-20 |
| 8/13/23 | @ LV | L34-7 |
San Francisco 49ers Injury Report
| Team | Status | DATE |
|---|---|---|
| Ambry Thomas CB | Questionable | Sep 20 |
| Brandon Aiyuk WR | Questionable | Sep 20 |
NFC West Standings | San Francisco 49ers
| Name | Position | W | L | T | Strk |
|---|---|---|---|---|
| San Francisco 49ers | 2 | 0 | 0 | W2 |
| Los Angeles Rams | 1 | 1 | 0 | L1 |
| Seattle Seahawks | 1 | 1 | 0 | W1 |
| Arizona Cardinals | 0 | 2 | 0 | L2 |
New York Giants at San Francisco 49ers Betting Trends | Thursday Night Football
- 49ers games last season went over this contest’s total of 44 points nine times.
- Thr average point total in San Francisco’s contests last season was 42.2, 1.8 fewer points than this game’s over/under.
- 49ers’ record against the spread last season was 11-6-0.
- 49ers finished 12-3 in games they were listed as the moneyline favorite last season (winning 80% of those games).
- San Francisco played as a moneyline favorite of -600 or shorter in only one game last season, which it won.
- Giants and their opponents combined to score more than 44 points in nine of 17 games last season.
- Thr average over/under for New York’s outings last year was 42.7, 1.3 fewer points than this game’s point total.
- Giants covered the spread 13 times in 17 games last season.
- Giants were underdogs 12 times last season and won six, or 50%, of those games.
- Last season, New York was at least a +425 underdog on the moneyline one time, losing that contest.
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| Kansas City Chiefs | +480 |
| San Francisco 49ers | +520 |
| Baltimore Ravens | +930 |
| Philadelphia Eagles | +960 |
| Detroit Lions | +990 |
| Buffalo Bills | +1175 |
| Houston Texans | +1300 |
| Dallas Cowboys | +1475 |
| New York Jets | +1475 |
| Cincinnati Bengals | +1625 |
| Miami Dolphins | +2300 |
| Atlanta Falcons | +2900 |
| Los Angeles Rams | +3000 |
| Chicago Bears | +3100 |
| Green Bay Packers | +3100 |
| Los Angeles Chargers | +3200 |
| Cleveland Browns | +3900 |
| Pittsburgh Steelers | +4100 |
| Jacksonville Jaguars | +4500 |
| New Orleans Saints | +4900 |
| Minnesota Vikings | +5400 |
| Seattle Seahawks | +5800 |
| Tampa Bay Buccaneers | +6200 |
| Indianapolis Colts | +8000 |
| Las Vegas Raiders | +9000 |
| Arizona Cardinals | +11000 |
| Washington Commanders | +13000 |
| Denver Broncos | +14000 |
| New England Patriots | +14000 |
| Tennessee Titans | +16000 |
| New York Giants | +17000 |
| Carolina Panthers | +40000 |
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