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Two teams desperate for something positive take to the field at Lucas Oil Stadium on Monday night when Pittsburgh takes on the Indianapolis Colts. Neither team projects to make the playoffs. But both have yet to be eliminated from playoff contention. Can the Steelers grab their fourth win of the season? Or will Indianapolis lock down their fifth victory? Check out NFL Odds, analysis, and a free pick for Colts hosting Steelers.

NFL Week 12 Betting Preview for Pittsburgh Steelers at Indianapolis

Monday Night Football: Pittsburgh versus Indianapolis Odds and Match Info

When: Monday, Nov. 28 at 8:15 pm ET
Where: Lucas Oil Stadium, Indianapolis, IN
TV / Streaming: ESPN / ESPN+
ATS Odds: Indianapolis -2.5
Money line Odds: Pittsburgh +115 / Indianapolis -140
Over/Under Odds: 39.5

Why bet on Pittsburgh versus Indianapolis?

The Steelers’ defense gives up a lot of passing yards. But Pittsburgh is solid against the rush. The road team has a big chance of stopping Indianapolis’ rushing attack.

If that happens, the Steelers will force the Colts to pass the ball. Indianapolis’ passing attack has been dreadful this season. So Pittsburgh should have the edge if the Colts must pass.

Pittsburgh Steelers Offensive Averages

Total Yards: 312.2

Passing Yards: 204.4

Rushing Yards: 107.8

Points Scored: 17.0

Turnovers: 14

Pittsburgh Steelers Defensive Averages

Total Yards: 375.5

Passing Yards: 2727.1

Rushing Yards: 103.4

Points Scored: 24.4

Takeaways: 14

Why bet on Indianapolis versus Pittsburgh?

Indianapolis heads into this game off a loss, but the Colts played great in NFL Week 11 versus a much better team than the Steelers. Facing the Philadelphia Eagles, many didn’t expect the Colts to have much chance.

Indianapolis pushed Philly throughout, losing by a single point, 17-16, at the final whistle. The Colts are 2-0 ATS in Jeff Saturday’s two games as head coach. Indianapolis is playing much better with Saturday on the sidelines than former coach Frank Reich.

Indianapolis Colts Offensive Averages

Total Yards: 321.4

Passing Yards: 222.6

Rushing Yards: 98.7

Points Scored: 15.7

Turnovers: 19

Indianapolis Colts Defensive Averages

Total Yards: 307.6

Passing Yards: 194.2

Rushing Yards: 113.5

Points Scored: 20.0

Takeaways: 10

Steelers at Colts Relevant Trends

Steelers are 3-7 ATS in their last 10 games on the road
Pittsburgh is 1-4-1 ATS in their last 6 versus the AFC
Under is 6-1 in the Steelers’ last 7 after an ATS loss
Colts are 7-3 ATS in their last 10 games following a straight up loss
Indianapolis is 1-4 ATS in their last 5 home games versus a team with a losing record
Under is 6-1 in the Colts’ last 7 home games

Pittsburgh Steelers vs Indianapolis Colts Final Betting Prediction

At first glance, the Colts should win this. But there are a few things in Pittsburgh’s favor. First, the Steelers have beaten the Colts in 7 straight games.

Fourteen seasons have passed since Indianapolis last beat Pittsburgh. Second, Pittsburgh running back Najee Harris has rumbled for 187 combined yards in Pittsburgh’s last couple of games.

Third, Steelers’ DE TJ Watt is one-hundred percent healthy. If the Steelers can force the Colts to abandon the run, Watt and his mates will tee off on close to immobile quarterback Matt Ryan.

No doubt, this can go either way. But since nothing happened over the weekend to change things, the road squad with the edge, and the one offering better odds, gets the call.

NFL Week 12 Pick: Pittsburgh +115