NFL Week 1 Odds, Betting Prediction: Chiefs vs Cardinals

The Kansas City Chiefs begin their quest for Super Bowl rings in Arizona on Saturday when Patrick Mahomes leads KC to The Valley to take on the Cardinals. The Chiefs started out a -3.5 chalk. The closer we’ve gotten to kick off the more NFL handicappers have backed the Chiefs. Will Kansas City escape Arizona with a win and cover? Or will the Cardinals prove they can hang with one of the top teams in the league? Check out NFL Odds, analysis, and a free pick for Kansas City at Arizona.

NFL Kansas City Chiefs at Arizona Analysis and Odds Preview for Week 1

NFL Week 1: Kansas City Chiefs versus Arizona Cardinals

When: Sunday, Sep. 11 at 4:25 pm ET
Where: State Farm Stadium, Glendale, AZ
TV / Streaming: CBS / Paramount +
ATS Odds: Kansas City -6
Moneyline Odds: Kansas City -248 / Arizona +197
Over/Under Odds: 53.5

Why bet on Kansas City versus Arizona?

Patrick Mahomes must play this game without Tyreek Hill, whom the Chiefs traded to Miami after last season, but KC’s quarterback and the offense should be just fine. Mecole Hardman has developed into a reliable target. Juju Smith-Schuster and Marques Vadez-Scantling have plenty of experience, which means KC’s offense will rock like it always does.

Kansas City Chiefs Offensive Averages

** Stats from 2021

Total Yards: 396.8

Passing Yards: 281.8

Rushing Yards: 115.0

Points Scored: 28.2

Turnovers: 25

Kansas City Chiefs Defensive Averages

** Stats from 2021

Total Yards: 368.9

Passing Yards: 251.4

Rushing Yards: 117.6

Points Scored: 21.4

Takeaways: 27

Why bet on Arizona versus Kansas City?

The Cardinals must play without wide receiver DeAndre Hopkins, who is suspended for the first six games, but that doesn’t mean Arizona won’t move the football. Zach Ertz returns at tight-end. Also, Rondale Moore, Marquise Brown, and A.J. Green will make up for Hopkins’ absence. Kyler Murray has plenty of weapons to target in the passing game.

Arizona Cardinals Offensive Averages

** Stats from 2021

Total Yards: 373.6

Passing Yards: 251.5

Rushing Yards: 122.1

Points Scored: 26.4

Turnovers: 15

Arizona Cardinals Defensive Averages

** Stats from 2021

Total Yards: 329.2

Passing Yards: 214.4

Rushing Yards: 114.8

Points Scored: 21.5

Takeaways: 27

Chiefs at Cardinals Relevant Trends

Chiefs are 4-1 ATS in their last 5 games in week 1
Kansas City is 8-3 ATS in their last 11 games
Over is 7-1 in the Chiefs’ last 8 games
Cardinals are 0-5 ATS in their last 5 at home
Arizona is 6-1 ATS in their last 7 games as an underdog
Over is 5-1 in the Cardinals’ last 6 games on grass

Kansas City Chiefs at Arizona Cardinals Final Betting Prediction

The line on Chiefs versus Cardinals has steadily moved from the opening -3.5. Kansas City should be one of the better teams in the NFL this season. So the line movement makes sense.

The jury is out on Arizona. Another reason the line move makes sense. But the Cardinals have enough talent to keep this closer than 6 points. If the line had moved from -3.5 to -4, the Chiefs might be the play. At -6, KC is an underlay.

No doubt, Mahomes and the Chiefs will move the football. The Arizona offense will also move the football. Not only that, but it’s going to be scorching in The Valley on Sunday. So the team that’s used to the heat, that’s AZ, figures to have an edge. The Cardinals and the points is the best play.

NFL Week 1 Pick: Arizona Cardinals +6

I have read enough, I need to place my bet now. What to do?