Serie A Matchday 16 Betting Lines for the Best Games of the Week

Italian Serie A resumes their 2022-2023 season on Wednesday Jan. 4. Top matchups include AC Milan traveling to Salernitana and Juve heading to Cremonese. Inter Milano hosts Napoli a huge favorite. Can Inter make up ground on the Serie A standings leader? See below for Serie A Odds, analysis, and free picks for six of Wednesday’s best Serie A matches.

Top Italy Serie A Matchday 16 Games to Wager On (November 12th – 13th)

Salernitana +1.5 -166 vs AC Milan -1.5 +130

When: Wednesday, Jan. 4 at 6:30 am ET

Salernitana fell by 3 goals to Monza in their final match before the break. The home dog in this had a prep on Dec. 10, losing 0-3 to Fenerbahce.

AC Milano beat Liverpool 4-1 in their tune-up for the league restart. The match happened on Dec. 16. It was a while ago, but AC should be ready. The possible payout makes backing AC Milan the way to go.

Soccer Pick: AC Milan -142

Spezia +370 vs Atalanta -142

When: Wednesday, Jan. 4 at 8:30 am ET

Atalanta was in terrible form right before the World Cup hiatus. The favored team in this matchup had lost 4-of-5 and 3 straight.

Spezia drew versus Udinese and beat Hellas Verona in their last 2 matches. Although Atalanta showed horrible form before the break, they’re the team to back. The road chalk dusted Spezia in the last head-to-head.

Soccer Pick: Atalanta

AS Roma -162 vs Bologna +480

When: Wednesday, Jan. 4 at 10:30 am ET

During the World Cup, AS Roma stayed busy. The home chalk in this contest has played 5 club friendlies since the break.

Roma’s last club friendly came on Dec. 22. In that match, Roma beat RKC Waalwijk 3-0. Bologna would be up against it no matter the circumstances. In this case Roma has kept warm.

Soccer Pick: AS Roma

Lecce +265 vs Lazio +111

When: Wednesday, Jan. 4 at 10:30 am ET

Both of these squads won their final 2 Serie A matches before the break. The difference is that Lecce hasn’t played since beating Sampdoria 2-0 on Nov. 12.

Lazio beat Galatasaray 2-1 in a club friendly on Dec. 13. Lecce upset Lazio in the last head-to-head but that happened back in 2020. The road team is the play.

Soccer Pick: Lazio

Cremonese +420 vs Juventus -149

When: Wednesday, Jan. 4 at 12:30 pm ET

Juve began the break by winning their final 3 Serie A matches. A couple of the wins were versus Inter Milano and Lazio.

Cremonese shows 3 draws and 2 losses in their last 5. Juve has played 2 club friendlies, including 1 on Dec. 22, winning both. Juventus rolls.

Soccer Pick: Juventus

Inter Milano +125 vs Napoli +216

When: Wednesday, Jan. 4 at 2:45 pm ET

On Dec. 17, Napoli lost a club friendly versus Villareal. That in no way should affect how Napoli plays in this match.

These two drew 1-1 in the last head-to-head. Inter has the edge because this happens on their pitch. But Napoli is an overlay at the odds. The road team gets the nod.

Soccer Pick: Napoli

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