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The Serie A schedule this weekend is an interesting one, as the top teams in the league have mostly avoided playing one another. But the matchups between top-tier teams and lesser opponents have the potential to be very interesting from a betting perspective. Here, we look at the top Serie A betting opportunities for this week, which include a couple of those matchups along with one between two higher-profile combatants.

Top Italy Serie A Matchday 24 Games to Wager On (January 21st)

Empoli vs. Napoli

When: Saturday, February 25
Where: Stadio Carlo Castellani, Empoli, Italy

Time: 12:00 PM EST
TV: Paramount+

On Saturday, league leaders Napoli pay a visit to Empoli, whose goal for this season has become to simply stay up in Serie A. Napoli is a heavy favorite, as expected, as they have been on absolute fire in the league of late. However, this may be a great opportunity to bet against them in the spread market, as Empoli has the potential to keep this game a little closer than anticipated.

Over their last five matches in Serie A play, Empoli has taken at least a point four times. That includes a match where they shocked Inter Milan with a 1-0 win at the San Siro. While it is unlikely that Empoli springs another upset with an outright win, they have the potential to keep this match within a goal, or even steal a draw from the team that looks likely to lift the Serie A trophy at the end of the season.

Bologna vs. Inter

When: Sunday, February 26
Where: Stadio Renato Dall’Ar, Bologna, Italy

Time: 6:30 AM EST
TV: Paramount+

As the Serie A calendar shifts to Sunday, a match between Bologna and Inter Milan will be one worth monitoring for soccer bettors. Inter has been playing incredibly as well of late, with their most recent triumph coming during the week in the Champions League. But a road match the weekend after a major European conquest could be a prime letdown spot for one of the hottest teams in all of Europe.

Here, it is worth keeping an eye on who will be taking the field for Inter, as they could rotate their squad in a major way. Having just played a few days ago in the Champions League, they will not want to risk injury to their top stars, especially against an opponent further down the table. That could open the door for Bologna to steal this one.

AC Milan vs. Atalanta

When: Sunday, February 26
Where: Stadio San Siro, Milan, Italy

Time: 2:45 PM EST
TV: Paramount+

Our final Serie A betting look for this weekend comes in a match between AC Milan and Atalanta. There will be plenty of firepower on both sides of this match, which will make for a fun time for fans and bettors alike. As a result, it is worth taking a look at the over in this matchup, which will be one of the best of the weekend, thanks to there being so many quality attackers on both sides of the pitch.

This match features two of the top-10 scorers in Serie A, one on each side. Combine them with several other quality players, and we could see a match similar to Milan’s recent 5-2 affair against Sassuolo. Look for an over here to close out the Serie A weekend.