2023 Serie A Odds and Analysis for the Top Matchday 4 Games

One of the historic rivalries in European soccer happens on Saturday when Internazionale takes on AC Milan.

Although Inter lists as the home squad, both teams play home games at the Giusseppe Meazza, so there is no real home team. Also on Saturday, Juve is in action against Lazio. And then on Sunday, AS Roma hosts Empoli.

Keep reading for betting analysis, including the Serie A betting lines, and picks for the top matchups that Matchday 4 has for this weekend.

Italian Serie A Betting Odds and Analysis for Matchday 4 Games | MyBookie SerieA Preview

Italian Serie A: Matchday 4 | Friday, September 16th – Monday, September 18th, 2023

Juventus vs Lazio

Premier Odds: Juventus -110; Lazio +320
Saturday, September 16th at 9:00 am ET | Matchday 4
Olimpico, Roma, Italy

Lazio hadn’t been playing well until their last. The road underdog in this has lost 2 straight, 2-1 versus Lecce and 0-1 versus Genoa, before upsetting Napoli 2-1.

Juventus has won 3-of-5 with 2 draws. What’s interesting is that both of Juve’s Serie A wins this season came on the road. Juventus drew 1-1 against Bologna in their last home game.

For sure, Juve should be the chalk, but at -110, Juventus is an underlay. Lazio is the pick.

Serie A Pick: Lazio | Bet Juventus vs Lazio Today
MyBookie Betting Lines for the Game

Internazionale vs AC Milan

Premier Odds: Internazionale +113; AC Milan +236
Saturday, September 16th at 12:00 pm ET | Matchday 4
Olimpico, Roma, Italy

After 3 Serie A matchdays, Inter and AC are both undefeated. Home team Inter beat Monza, Cagliari, and Fiorentina.

Road squad AC Milan beat Bologna, Torino, and Roma. In this rivalry, both squads tend to play exceptional soccer. So the draw is a possibility. But AC has beaten the better opponents and Christian Pulisic has proven to be a difference maker. AC Milan gets the nod.

Serie A Pick: AC Milan | Bet Inter vs AC Milan Today
MyBookie Betting Lines for the Game

Genoa vs Napoli

Premier Odds: Genoa +410; Napoli -149
Saturday, September 16th at 2:45 pm ET | Matchday 4
Luigi Ferraris, Genova, Italy

Genoa has lost 2-of-3. The home underdog beat Lazio 1-0 on August 27. Genoa also has a 4-3 win over Modena in a Coppa Italia match on August 11.

Napoli heads into this after their first loss, a 2-1 game against Lazio. But although Napoli suffered their first loss of the season, we should expect the Napoleons to bounce back in a big way. At -149, the road favorite is an overlay.

Serie A Pick: Napoli | Bet Genoa vs Napoli Today
MyBookie Betting Lines for the Game

Monza vs Lecce

Premier Odds: Monza +114; Lecce +248
Sunday, September 17th at 9:00 am ET | Matchday 4
U-Power Stadium, Monza, Italy

Monza shows a single win and 4 losses in their last 5. But Monza is the chalk because this happens on their pitch.

Lecce may be an overlay at +248. The road underdog has won 3-of-4 with a draw. Home pitch is meaningful but it’s not the and all and be all of soccer. Because of the odds, Lecce is the far better choice to get the regulation win.

Serie A Pick: Lecce | Bet Monza vs Lecce Today
MyBookie Betting Lines for the Game

Fiorentina vs Atalanta

Premier Odds: Fiorentina +141; Atalanta +182
Sunday, September 17th at 12:00 pm ET | Matchday 4
Artemio Franchi, Firenze, Italy

Neither squad is in great form, which is why the home team is the favorite. Also, although they lost their last, Fiorentina lost to one of Europe’s top squads, Internazionale.

Atalanta won their last match. The road dog beat Monza 3-0. Not only is Atalanta in better form, but the underdog in this offers a much better payout. Give Atalanta the nod.

Serie A Pick: Atalanta | Bet Fiorentina vs Atalanta Today
MyBookie Betting Lines for the Game

AS Roma vs Empoli

Premier Odds: AS Roma -1.5 +124; Empoli +1.5 -158
Sunday, September 17th at 2:45 pm ET | Matchday 4
Olimpico, Roma, Italy

As Roma is on a 2-match losing streak. But opponent Empoli is on a 5-match losing streak.

Empoli could keep a loss on Sunday to a goal. But at a -158 payout, it’s tough to back the road squad to keep it close. The payout on Roma entices more.

Serie A Pick: AS Roma -1.5 | Bet AS Roma vs Empoli Today
MyBookie Betting Lines for the Game

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