NFL Week 1 Odds: Buffalo Bills vs LA Rams Betting Prediction

On Thursday night, the Buffalo Bills and Los Angeles Rams kick off the 2022-2023 NFL Season. Buffalo is the road squad, but oddsmakers and handicappers are so bullish on Josh Allen and his mates that the Bills will entire SoFi a -2.5 chalk. Will the Bills prove why so many believe they’re this season’s team to beat? Or will the Rams step up their game on their turf? See below for NFL Betting Lines, analysis, and a free pick for Buffalo at LAR.

NFL TNF Buffalo Bills at LA Analysis and Odds Preview | Week 1 Betting Predictions

NFL Week 1 Bills versus Rams Match Info and Odds

When: Thursday, Sep. 8 at 8:20 pm ET
Where: SoFi Stadium, Inglewood, CA
TV / Streaming: NBC / Peacock
ATS Odds: Buffalo -2.5
Moneyline Odds: Buffalo -131/ LAR +108
Over/Under Odds: 52

Why bet on Buffalo versus LAR?

Buffalo continues to flow to the Bills not only to win Super Bowl 57 but to also beat the Rams and cover against the spread. Based on Buffalo’s upgrades, it makes sense. The Bills landed former Rams defensive end Von Miller. Buffalo also drafted Georgia running back James Cook. Both could have a big impact on this game.

Buffalo Bills Offensive Averages

** Stats from 2021

Total Yards: 381.9

Passing Yards: 252.0

Rushing Yards: 129.9

Points Scored: 28.4

Turnovers: 22

Buffalo Bills Defensive Averages

** Stats from 2021

Total Yards: 272.8

Passing Yards: 163.0

Rushing Yards: 109.8

Points Scored: 17.0

Takeaways: 27

Why bet on LAR versus Buffalo?

Los Angeles Rams won Super Bowl 56 by playing great defense and leaning on quarterback Matthew Stafford to wide receiver Cooper Kupp. The problem every team will have, including Buffalo in this game, is stopping Aaron Donald and keeping Kupp from dominating. So although on paper the Bills look like the better team, the Rams matchup great against Buffalo.

Los Angeles Rams Offensive Averages

** Stats from 2021

Total Yards: 372.1

Passing Yards: 273.1

Rushing Yards: 99.0

Points Scored: 27.1

Turnovers: 23

Los Angeles Rams Defensive Averages

** Stats from 2021

Total Yards: 344.9

Passing Yards: 241.7

Rushing Yards: 103.2

Points Scored: 21.9

Takeaways: 24

Bills at Rams Relevant Trends

Bills are 12-5 ATS in their last 17 week 1 games
Buffalo is 5-2 ATS in their last 7 games in September
Under is 7-2 in the Bills last 9 games in week 1
Rams are 10-4 ATS in their last 14 games in September
LAR is 1-4 ATS in their last 5 games on field turf
Over is 5-0 in the Rams last 5 games in September

Buffalo Bills at Los Angeles Rams Final Betting Prediction

In last week’s early first game of the season pick blog, going with the Bills made sense. Buffalo is hot in the futures and the Bills sure look like they’re on their way to an AFC Conference clash with either the Bengals or Chiefs.

But Buffalo doesn’t always start out the season playing their best ball. In 2021, the Bills failed to cover the spread versus a team many thought they would spank, the Pittsburgh Steelers.

This season, the Bills tackle the defending Super Bowl champs in week 1. Not only that, but the Bills must contend with a defense that added former Seahawks linebacker Bobby Wagner. Also, LB Leonard Floyd and corner Jalen Ramsey have no injury designation this week.

Nor does quarterback Matthew Stafford. Buffalo is a great football team. But they are an underlay at -2.5. This happens in Los Angeles’ stadium, Donald is being paid the way he should, and everything is copasetic between Stafford and Kupp. The Rams win straight up.

NFL Week 1 Pick: Los Angeles Rams +108

I have read enough, I need to place my bet now. What to do?