The San Francisco 49ers will take their talent to Cleveland to battle the Browns in a Week 6 affair on Sunday. The San Francisco 49ers are one of two remaining teams in the National Football League without a loss.
The 49ers are coming off the blowout win on Sunday Night Football over the Dallas Cowboys. The 49ers have won their last two games by a combined score of 77-26.
For Cleveland, they are coming off a bye last week, which they hope came at a great time, as they were smashed in Week 4 by the Ravens 28-3. Cleveland is 2-2 on the season.
The San Francisco 49ers are favorites in this game on Sunday. The 49ers are listed at -6, while the total for this game is at 37.5 points.
MyBookie offers the game prediction plus NFL odds, analysis, along with a free pick for San Francisco 49ers versus the Cleveland Browns which are playing on Week 6 of the season.
49ers vs Browns Betting Prediction: Get Your NFL Odds for the Game | MyBookie NFL Week 6 Regular Season Preview
San Francisco 49ers vs Cleveland Browns | NFL Week 6
ATS: 49ers -6.5
Money line: 49ers -294 / Browns +230
Over/Under: 37.5
Sunday, October 15th, 2023 at 1:00 pm ET | FOX
Cleveland Browns Stadium, Cleveland, OH
Browns Looking to Spark Offense
The Browns need to figure it out on the offensive side. DeShaun Watson has shown some signs of brilliance but then some signs of big-time struggles.
Watson and the Browns offense is averaging just 172.5 passing yards per game, the third worst in the National Football League. Cleveland does a good job on the ground despite losing the season’s top running back, Nick Chubb. The Browns are averaging 143.8 yards per game on the ground.
Kareem Hunt and Jerome Ford now lead the rushing attack. Ford leads the team with 186 yards and a touchdown, while Hunt has been limited since his return with just ten attempts and 25 yards.
Cleveland has back-to-back road games following this to wrap up the month of October. The Browns are at the Indianapolis Colts in Week 8 and then Seattle in Week 9.
McCaffrey Continues to Run Wild
Christian McCaffrey is arguably the best running back in the National Football League. He may be the best offensive player overall, as well. McCaffrey has 99 carries on the season for 510 yards and seven touchdowns. He also has 20 receptions for 168 yards and an additional touchdown.
The 49ers rank 8th with 246 passing yards per game and 3rd with 156.4 rushing yards per game. San Francisco is second to Miami in points, with 33.4 per game.
The 49ers do not want you to forget about their defense. The defense is allowing just under 285 total yards per game. The defense is allowing just 64.2 rushing yards per game, and the defense that is giving up just 13.6 points per game. Fred Warner leads the charge on the defensive end, with 29 tackles, while Nick Bosa has 1.5 sacks through five games.
The 49ers will play back-to-back road games. Following this game, they will go on the road for a Monday Night Football affair against the Vikings. After that, the 49ers will finish the month at home against the Cincinnati Bengals.
They then take their bye week in Week 9 before going to Jacksonville.
49ers vs Browns Betting Prediction | 49ers Tough to Take Down
The Browns are going to have a good game plan. They will do a little to disrupt Brock Purdy and the San Francisco offense. But, in the end, one team is much better. Cleveland has made strides and continues to get better, but not here.
The 49ers are not going to lose their first game here. Look for the 49ers to lead in a close one at the half but win by double digits in the second half to secure their sixth straight win.
Take the San Francisco 49ers -6.5 over the Cleveland Browns when betting on this game. McCaffrey scores twice, and the 49ers win easily on Sunday!
NFL Week 6 Pick: 49ers -6.5 | Bet 49ers vs Browns
MyBookie Betting Lines for the Game
San Francisco 49ers Last 5
| Date | OPP | Result |
|---|---|---|
| 10/8/23 | vs DAL | W42-10 |
| 10/1/23 | vs ARI | W35-16 |
| 9/21/23 | vs NYG | W30-12 |
| 1/17/23 | @ LAR | W30-23 |
| 9/10/23 | @ PIT | W30-7 |
San Francisco 49ers Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Aaron Banks G | Questionable | Oct 9 |
| Elijah Mitchell RB | Questionable | Oct 10 |
| – |
NFC West Standings | San Francisco 49ers
| Team | W | L | T | Strk |
|---|---|---|---|---|
| San Francisco 49ers | 5 | 0 | 0 | W5 |
| Seattle Seahawks | 3 | 1 | 0 | W3 |
| Los Angeles Rams | 2 | 3 | 0 | L1 |
| Arizona Cardinals | 1 | 4 | 0 | L2 |
Cleveland Browns Last 5
| Date | OPP | Result |
|---|---|---|
| 10/1/23 | vs DAl | L28-3 |
| 9/24/23 | vs TEN | W27-3 |
| 1/18/23 | @ PIT | L26-22 |
| 9/10/23 | vs CIN | W24-3 |
| 8/26/23 | @ KC | W33-32 |
Cleveland Browns Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Joel Bitonio G | Questionable | Oct 9 |
| David Njoku TE | Questionable | Oct 10 |
| Deshaun Watson QB | Questionable | Oct 11 |
AFC North Standings | Cleveland Browns
| Team | W | L | T | Strk |
|---|---|---|---|---|
| Pittsburgh Steelers | 3 | 2 | 0 | W1 |
| Baltimore Ravens | 3 | 2 | 0 | L1 |
| Cleveland Browns | 2 | 2 | 0 | W1 |
| Cincinnati Bengals | 1 | 4 | 0 | L2 |
San Francisco 49ers at Cleveland Browns Betting Trends
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Longest Rush Over in his last 7 away games (+7.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
- Nick Chubb has hit the Longest Rush Over in 12 of his last 15 games (+8.30 Units / 47% ROI)
- Donovan Peoples-Jones has hit the Longest Reception Over in 10 of his last 12 games (+7.65 Units / 55% ROI)
- Nick Chubb has hit the Rushing Yards Over in 12 of his last 17 games (+6.25 Units / 32% ROI)
- Nick Chubb has hit the Receptions Under in his last 6 games at home (+6.00 Units / 59% ROI)
- Amari Cooper has hit the Receiving Yards Over in 7 of his last 8 games at home (+5.95 Units / 66% ROI)
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| Kansas City Chiefs | +460 |
| San Francisco 49ers | +590 |
| Buffalo Bills | +1050 |
| Houston Texans | +1075 |
| Philadelphia Eagles | +1175 |
| Detroit Lions | +1200 |
| Baltimore Ravens | +1375 |
| Dallas Cowboys | +1825 |
| New York Jets | +1825 |
| Cincinnati Bengals | +1925 |
| Green Bay Packers | +2500 |
| New Orleans Saints | +2600 |
| Atlanta Falcons | +3100 |
| Tampa Bay Buccaneers | +3700 |
| Pittsburgh Steelers | +3900 |
| Seattle Seahawks | +3900 |
| Los Angeles Chargers | +3900 |
| Minnesota Vikings | +4100 |
| Miami Dolphins | +4400 |
| Cleveland Browns | +4700 |
| Chicago Bears | +4900 |
| Jacksonville Jaguars | +6200 |
| Arizona Cardinals | +6200 |
| Los Angeles Rams | +7500 |
| Las Vegas Raiders | +9000 |
| Indianapolis Colts | +10000 |
| Washington Commanders | +14000 |
| Tennessee Titans | +22000 |
| New England Patriots | +24000 |
| Denver Broncos | +36000 |
| New York Giants | +42000 |
| Carolina Panthers | +70000 |
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