49ers at Carolina Odds for Week 5, 2022 NFL Season

A couple of NFL squads moving in opposite directions face off on Sunday when the Carolina Panthers host the San Francisco 49ers at Bank of America Stadium in Charlotte. Carolina has lost 3-of-4. San Francisco got back to .500 in their last in a terrific victory over the rival Los Angeles Rams. Will the Panthers keep the game closer than the spread? Or will the Niners hand Carolina another embarrassing loss? Keep reading for NFL Lines, analysis, and a free pick for San Francisco at Carolina.

NFL Week 5 Betting Preview for San Francisco versus Carolina

San Francisco 49ers at Carolina Panthers Lines and Match Info

When: Sunday, Oct. 9 at 4:05 pm ET
Where: Bank of America Stadium, Charlotte, NC
TV / Streaming: CBS / Paramount
ATS Odds: San Francisco -6.5
Moneyline Odds: San Francisco -300 / Carolina +234
Over/Under Odds: 39

Why bet on San Francisco versus Carolina?

The 49ers turned the corner in an incredible 24-9 Monday night win against the Rams. San Francisco blasted the rival Rams. Deebo Samuel was unreal in a 57-yard catch and run from Jimmy Garoppolo. Tafua Hufunga picked off Matthew Stafford and ran it back for a TD. The 49ers are rolling, which means Carolina should have no chance of keeping it close.

San Francisco 49ers Offensive Averages

Total Yards: 324.5

Passing Yards: 189.3

Rushing Yards: 135.3

Points Scored: 17.8

Turnovers: 5

San Francisco 49ers Defensive Averages

Total Yards: 234.5

Passing Yards: 161.3

Rushing Yards: 73.3

Points Scored: 11.5

Takeaways: 5

Why bet on Carolina versus San Francisco?

The Panthers played well against the Arizona Cardinals in their last. Even though Carolina lost the game, they had their chances, which means the Panthers blew it due to mental mistakes. Carolina must only only stick to the game plan and not make mental errors to keep this within the 6.5 spread. Doing so starts with quarterback Baker Mayfield, who tends to push too much. Mayfield must be patient. If he is, Carolina can win this ATS.

Carolina Panthers Offensive Averages

Total Yards: 262.3

Passing Yards: 166.0

Rushing Yards: 96.3

Points Scored: 19.5

Turnovers: 6

Carolina Panthers Defensive Averages

Total Yards: 346.0

Passing Yards: 212.0

Rushing Yards: 134.0

Points Scored: 21.3

Takeaways: 4

49ers at Panthers Relevant Trends

49ers are 8-3 ATS in their last 11 games on grass
San Francisco is 7-1 ATS in their last 8 versus the NFC
Under is 4-0 in the 49ers’ last 4 games following an ATS win
Panthers are 1-7 ATS in their last 8 games on grass
Carolina is 3-15 ATS in their last 18 games
Under is 5-1 in the Panthers’ last 6 versus the NFC

San Francisco 49ers at Carolina Panthers Final Betting Prediction

The home team Panthers are a mess. On paper, Carolina should beat teams like San Francisco ATS. But Carolina won’t because the mental errors aren’t just coming from Mayfield.

The Panthers’ defense makes mistakes. The coaching staff makes mistakes. The entire organization is a mess.

More importantly, the San Francisco 49ers finally played a full game against a top opponent. The Niners should continue the good times. San Francisco’s defense will dominate Mayfield and the Panthers’ offense while Jimmy G. and Deebo should have no trouble marching down the field and scoring touchdowns. San Francisco blows past the spread with an easy win and cover.

NFL Week 5 Pick: San Francisco 49ers -6.5

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