SF 49ers vs AZ Cardinals Lines & Pick - NFL Week 11 Prediction

As part of Week 11’s Monday Night Football game between the Arizona Cardinals and San Francisco 49ers at Estadio Azteca, we’ll see some NFL action in Mexico City for the first time since 2019. Following victories over the NFL clubs from Los Angeles in Week Ten, both teams will travel to Mexico City looking to make up ground in the NFC West.

The Cardinals defeated the Rams 27-17 at SoFi Stadium, with veteran quarterback Colt McCoy playing in place of the injured Kyler Murray (hamstring), while the Niners overcame a three-point deficit to defeat the Chargers at home 22-16. Let’s take a closer look at both teams and how they stack up against each others so you can bet on their NFL Odds.

NFL Week 11 Betting Preview: Niners versus Cardinals Analysis

49ers Hope to Push Winning Streak to Three

The 49ers have started to look like one of the best teams in the NFC, thanks to some strong play on both sides of the ball. Jimmy Garrapolo and the offense led a come-from-behind victory over the Chargers and are now a half-game back from first place in the division.

Last Sunday’s game against the Chargers featured only 39 yards from Christian McCaffrey and a touchdown, but it was still a successful night for San Francisco’s ground game thanks to Elijah Mitchell, who returned and averaged nearly five yards per rush.

With McCaffrey, Deebo Samuel, and George Kittle in the mix, the 49ers’ offense is still tremendously explosive. The offense scores 22 points each game on average while gaining 360 yards per game overall.

On the defensive side, the 49ers have been one of the best units in the league. In the team’s 22-16 victory over the Chargers, the San Francisco 49ers’ defense recorded three sacks and one interception. The unit pitched a shutout in the second half for the second consecutive game, and they remain one of the top-five units in the league.

Arizona Cardinals Look to Make up Ground in the NFC West

For the first time this season, the Arizona Cardinals played a complete game and were able to take down the Rams on the road. After scoring 42 points against the Saints in Week Seven and 29 points in their overtime victory against the Raiders in Week Two, Arizona was finally able to put together a solid scoring effort for their third-highest total of the season.

Although McCoy wasn’t particularly impressive, he did throw for 238 yards and a touchdown while avoiding any turnovers. Although they managed just under 300 yards, James Connor rushed for two touchdowns in his return, while the offense committed zero turnovers. Overall, the offensive unit is just 23 points per game.

In their victory over the Rams, the Cardinals’ defense put together one of their best efforts of the season, limiting them to just 17 points and 256 yards. In addition, they recorded three sacks and collected a fumble and interception. When the Cardinals meet the Niners on Monday night, they will be put to a greater test.

Betting Lines & Odds

The 49ers are the road favorites according to sportsbooks, and the line for this encounter is set at 8 points (-110). In terms of the moneyline, the Cardinals are classified as home underdogs at +290, while the 49ers are given odds of -350 to win on the road. The Over/Under for this contest is 43.5 points (-110).

Betting Pick

The Arizona Cardinals come into this matchup just 1-4 at home and could potentially be without their star quarterback Kyler Murray. The Cardinals are also just 1-2 ATS in their last three contests. Meanwhile, the 49ers have figured things out on both sides of the ball, and they are incredibly dangerous.

San Francisco is looking to secure the top spot in the NFC West, and they are a lot healthier than the Cardinals right now. Despite the high number, I expect the 49ers to go into Arizona and completely blow this team out.

Prediction: 49ers -8 (-110)