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The San Francisco 49ers remain alive for the NFC Playoffs’ top seed. The Niners beat the Cardinals and the Giants upset the Eagles, San Francisco can take the top seed. No doubt, SF should win this game, but the spread line is massive. Will the 49ers do enough to cover the -14 spread? Or will Arizona do enough to keep the score difference closer than the spread? See below for NFL odds, analysis, and a free pick for Cardinals at 49ers.

NFL Week 18 Betting Preview and Odds for Arizona Cardinals at San Francisco 49ers

Sunday Football: Cardinals versus 49ers Odds and Match Info

• When: Sunday, Jan. 8 at 4:25 pm ET
• Where: Levi’s Stadium, Santa Clara, CA
• TV / Streaming: FOX
• ATS Odds: San Francisco -14
• Money line Odds: Arizona +600 / San Francisco -1000
• Over/Under Odds: 40

Why bet on Arizona versus San Francisco?

Arizona isn’t close to San Francisco in terms of talent, but the Cardinals are good enough to cover the spread. AZ has gone 2-0 ATS in their last 2 games.

The Cards covered as a +7.5 underdog in a 16-19 overtime loss to Tampa two games ago. Then in their last game, Arizona covered as a +7 underdog in a 20-19 loss to Atlanta.

Arizona Cardinals Offensive Averages

• Total Yards: 327.8
• Passing Yards: 214.5
• Rushing Yards: 113.3
• Points Scored: 20.4
• Turnovers: 21

Arizona Cardinals Defensive Averages

• Total Yards: 351.3
• Passing Yards: 235.8
• Rushing Yards: 115.4
• Points Scored: 25.7
• Takeaways: 20

Why bet on San Francisco versus Arizona?

The 49ers required overtime in NFL Week 17 to get past the Las Vegas Raiders in a non-cover. But the Raiders switched things up by starting Jarrett Stidham.

The Cardinals will start David Blough at QB. San Francisco’s defense should go back to dominating opposing offenses. Not only that, but the 49rs had covered in 6 straight before facing the Raiders. There’s no reason to believe SF doesn’t go back to their covering ways.

San Francisco 49ers Offensive Averages

• Total Yards: 369.1
• Passing Yards: 232.1
• Rushing Yards: 136.9
• Points Scored: 25.8
• Turnovers: 17

San Francisco 49ers Defensive Averages

• Total Yards: 303.4
• Passing Yards: 224.7
• Rushing Yards: 78.8
• Points Scored: 16.5
• Takeaways: 24

Cardinals at 49ers Relevant Trends

• Cardinals are 1-7 ATS in their last 8 versus the NFC West
• Arizona is 5-0-1 ATS in the last 6 meetings in San Francisco
• Over is 7-3 in the Cardinals’ last 10 games
• 49ers are 4-0 ATS in their last 4 home games
• San Francisco is 5-1 ATS in their last 6 games on grass
• Over is 4-1 in the 49ers last 5 games

Arizona Cardinals at San Francisco 49ers Final Betting Prediction

San Francisco should win this game no problem but covering the spread could be difficult. It’s not that SF can’t cover 14 points but the Cardinals’ defense is playing great football.

Arizona held Tampa to 19 points and the Buccaneers required overtime to get the 19. Atlanta scored only 20. Also, San Francisco will be trying to win the contest, not blow out the Cardinals, which means Kyle Shanahan will call a conservative game.

14 points in the final regular season game of the season is way too many to give. San Francisco should win whether the 1-seed is at stake or not. But the Cardinals cover.

NFL Week 18 Pick: Arizona Cardinals +14