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San Francisco heads to Denver to take on the Broncos in NFL Week 3’s Sunday Night Football matchup. The 49ers lost starting quarterback Trey Lance in NFL Week 2. Lance broke an ankle that required a couple surgeries to repair. Trey will be okay but he’s out for the season. Will former starter Jimmy Garoppolo lead the Niners to victory? Or will the Broncos make it two straight wins? Check out NFL Betting Lines, analysis, and a free pick for San Francisco at Denver.

NFL Week 3 Betting Preview for San Francisco 49ers at Denver Matchup

Sunday Night Football: San Francisco 49ers vs Cleveland Odds and Game Info

When: Sunday, Sep. 25 at 8:20 pm ET
Where: Empower Field at Mile High, Denver, CO
TV / Streaming: NBC / Peacock
ATS Odds: San Francisco -1.5
Moneyline Odds: San Francisco -123 / Denver +100
Over/Under Odds: 44.5

Why bet on San Francisco versus Denver?

Before Lance got the starting quarterback job, Jimmy Garoppolo had led San Francisco to a Super Bowl appearance in 2020 and a divisional playoff appearance last season. Jimmy G. knows what he’s doing.

When Garoppolo entered the game against Seattle last Sunday, the 49ers had yet to blow open the game. San Francisco pulled away to a 27-7 win because Garoppolo ran the offense to perfection.

San Francisco 49ers Offensive Averages

Total Yards: 352.0

Passing Yards: 169.5

Rushing Yards: 182.5

Points Scored: 18.5

Turnovers: 2

San Francisco 49ers Defensive Averages

Total Yards: 210.0

Passing Yards: 142.5

Rushing Yards: 67.5

Points Scored: 13.0

Takeaways: 3

Why bet on Denver versus San Francisco?

Denver didn’t play a great game in NFL Week 2. But the Broncos showed they have what it takes to beat a hard-trying club. The Broncos entered their contest versus Houston a -9 favorite.

The home team beat the Texans 16-9. The game was as workmanlike as it gets. Russell Wilson threw for only 219 yards. But the Broncos rushed for an excellent 149. Denver has what it takes to beat the 49ers.

Denver Broncos Offensive Averages

Total Yards: 391.5

Passing Yards: 265.5

Rushing Yards: 126.0

Points Scored: 16.0

Turnovers: 3

Denver Broncos Defensive Averages

Total Yards: 243.5

Passing Yards: 165.5

Rushing Yards: 78.0

Points Scored: 13

Takeaways: 1

49ers at Broncos Relevant Trends

49ers are 6-1 ATS in their last 7 games
San Francisco is 7-2 ATS in their last 9 games on grass
Under is 4-0 in the 49ers’ last 4 games on the road
Broncos are 1-5 ATS in their last 6 games
Denver is 0-4 ATS in their last 4 games following a straight up win
Under is 6-0 in the Broncos’ last 6 games in September

San Francisco 49ers at Denver Broncos Final Betting Prediction

So far, things aren’t going as planned in Denver. Russell Wilson has not played his best. Versus the Texans, Russ struggled, completing just 14-of-31.

Wilson threw a pick. Denver’s offense should get it going. But it hasn’t yet, and that’s concerning if you’re a Broncos fan.

If you like the 49ers in this, you should feel comfortable laying the -1.5 on the road dog. Jimmy G. isn’t a drop off from Lance. In fact, Garoppolo may be better suited to lead the Niners to playoffs this season because he’s got more experience than Trey.

San Francisco’s defense is playing lights out. The 49ers rank first in yards allowed and passing yards allowed. The Niners D rank second in rushing yards allowed and third in points per game at 13. SF wins and covers.

NFL Week 3 Pick: San Francisco 49ers -1.5

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