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Two teams desperate for a victory clash on Thursday night when the Indianapolis Colts head to Denver to take on the Broncos. Both franchises entered the season with high expectations. Heading into NFL Week 5, neither has lived up to those expectations. Will Russell Wilson and the Broncos win and cover? Or will Matt Ryan and the Colts hand another loss to Denver’s record? Keep reading for NFL Lines, analysis, and a free pick for Denver versus Indianapolis.

NFL Week 5 Betting Preview for Indianapolis Colts vs Denver Broncos

Thursday Night Football: Colts versus Broncos Lines and Match Info

When: Thursday, Oct. 6 at 8:15 pm ET
Where: Empower Field at Mile High, Denver, CO
TV / Streaming: Prime Video
ATS Odds: Denver -3
Moneyline Odds: Indianapolis +144 / Denver -177
Over/Under Odds: 42.5

Why bet on Indianapolis versus Denver?

Tennessee beat Indianapolis in the Colts’ last game but a positive came out of the loss. For the first time this season, new quarterback Matt Ryan played a great game. Matty Ice completed 27-of-37 for 356 yards. Ryan threw a pick, but he also threw a pair of touchdowns. The performance is something the Colts’ offense can build on.

Indianapolis Colts Offensive Averages

Total Yards: 339.8

Passing Yards: 252.0

Rushing Yards: 87.8

Points Scored: 14.3

Turnovers: 9

Indianapolis Colts Defensive Averages

Total Yards: 297.0

Passing Yards: 207.5

Rushing Yards: 89.5

Points Scored: 21.3

Takeaways: 2

Why bet on Denver versus Indianapolis?

Denver blew their last game, a contest versus the rival Las Vegas Raiders, but that doesn’t mean the Broncos won’t win and cover in this. The last time Denver played on their field, they upset the very good San Francisco 49ers. Russell Wilson has yet to have a breakout game but we know it’s going to happen. It could happen on Thursday night versus a worse than expected Indianapolis defense.

Denver Broncos Offensive Averages

Total Yards: 335.8

Passing Yards: 226.3

Rushing Yards: 109.5

Points Scored: 16.5

Turnovers: 4

Denver Broncos Defensive Averages

Total Yards: 284.8

Passing Yards: 170.8

Rushing Yards: 114.0

Points Scored: 17.0

Takeaways: 4

Colts at Broncos Relevant Trends

Colts are 1-5 ATS in their last 6 games overall
Indianapolis is 11-5 ATS in their last 16 games on the road
Under is 8-0 in the Colts’ last 8 versus the NFC
Broncos are 11-4 ATS in their last 15 games on a Thursday
Denver is 1-6 ATS in their last 7 games in October
Under is 9-3 in the Broncos’ last 12 games on grass

Indianapolis Colts at Denver Broncos Final Betting Prediction

The winner against the spread and straight up will be the team whose quarterback plays best. It’s not often we can write that, but in this case, it’s true.

Both teams play good enough defense to grab the victory. The question is which QB will step it up enough to lead his team.

Sounds crazy, but the quarterback with the edge is Matt Ryan. Matty Ice had his breakthrough game. So now, it’s a question of building upon the breakout performance.

Russell Wilson has yet to get on track. In fact, Russell has been downright second string-like in Denver’s first four games. Wilson couldn’t even beat up a bad Raiders’ defense.

Sure, Russell threw for 237 yards and a couple of touchdowns. But the Broncos had more in mind when Wilson signed the massive contract. The Colts played hard in the loss to the Titans while Denver appeared to give up in the loss to Vegas. Back Matty Ice and Indianapolis against the spread.

NFL Week 5 Pick: Indianapolis Colts +3

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