49ers vs Chiefs: Odds and How to Win 2024 Super Bowl

Previous Betting News

The Kansas City Chiefs beat the Baltimore Ravens and the San Francisco 49ers rallied to get by the Detroit Lions to set up a rematch of the 2020 Super Bowl. In that game, San Francisco had a decent lead before Patrick Mahomes rallied the Chiefs to victory.

On February 11, will Mahomes lead Kansas City to back-to-back Super Bowl victories? Or will Brock Purdy and the Niners get it done?

Let’s take a look at our betting preview as MyBookie offers the NFL lines for this Super Bowl match with the 49ers as favorites at -1 over the Chiefs and a total set at 47.5.

Early Analysis: Chiefs vs 49ers Odds and Betting Pick for this 2024 Super Bowl | MyBookie NFL Playoff Preview

Super Bowl LVIII | 58th edition of the annual league championship game of the National Football League
Kansas City Chiefs at San Francisco 49ers
ATS Odds: 49ers -1
Money line Odds: Kansas City Chiefs Line: +100 / San Francisco 49ers Line: -120
Over/Under Odds: 47.5

Sunday, February 11th, 2024 at 6:30 pm ET | CBS
Allegiant Stadium, Las Vegas, NV

Top 3 reasons the San Francisco 49ers will win the Super Bowl

Early Analysis: Which Team Will Win the Super Bowl? 49ers or Chiefs?

Brock Purdy and San Francisco’s offense is unstoppable
Purdy threw an early interception against the Detroit Lions, but then he rallied the 49ers in the second half. What that tells us is that Brock has what it takes to win a Super Bowl.

Few young quarterbacks would respond the way Purdy did after going down 24-7 at halftime. SF’s QB leads the best offense in the NFL.

The San Francisco defense stepped it up in the second half against the Lions
Not only did Purdy and the offense step it up, but San Francisco’s defense also played great. The 49ers D was like Swiss cheese in the first half, giving up huge chunks yardage on almost every Detroit run.

But in the second half, the defense picked it up. The Lions could get nothing going through the air or on the ground. The second half performance should be a huge confidence boost for the SF D.

No head coach adjusts as well as Kyle Shanahan
Kyle Shanahan didn’t panic after heading into halftime down 17 points. Instead, Shanahan instructed Steve Wilks, SF’s defensive coordinator, to make the necessary adjustments on D.

Shanahan tweaked the offense. The adjustments worked.

Top 3 reasons the Kansas City Chiefs will win the Super Bowl

Mahomes to Kelce is rocking
Patrick Mahomes and Travis Kelce are back to dominating defenses. Mahomes and Kelce rocked the Baltimore Ravens for 11 connections for over 100 yards and a touchdown.

The best QB to TE duo in history, yes, even better than Gronk and Brady, should be even more stellar in the Super Bowl.

The Chiefs defense is playing lights out
The reason Kansas City made it to their second straight Super Bowl is because Steve Spagnuolo’s unit was rock solid against both the Bills and the Ravens.

The blitzes Spags drew up to get to Lamar Jackson were genius level. Lamar never got comfortable and ended up throwing a costly interception that for all intents and purposes ended the game.  

Andy Reid will call the perfect game
Reid is one of the best strategists in the NFL. He’s a master at setting a game plan and calling it while adjusting when required.

Reid has a full two weeks to figure out how to beat San Francisco’s offense. So we should expect the Chiefs to be difficult to take down come February 11.

Early Analysis Final Call: Will the Chiefs or 49ers win Super Bowl 58?

The Kansas City Chiefs can accomplish back-to-back Super Bowl wins for the first time since the New England Patriots went back-to-back in 2004 and 2005.

However, although it’s been close to 20 years and we’re due for back-to-back SB winners, Kansas City doesn’t match up great with the 49ers. San Francisco’s offense took a light year step forward in the second half versus the Lions.

For sure, KC’s defense is playing great, but the Niners have too many weapons for Spags to deal with. At the end, SF gets it done.

2024 NFL Super Bowl ATS Pick: San Francisco 49ers -1 | Bet 49ers vs Chiefs
MyBookie Betting Lines for the Game

Previous Betting News

On Sunday, October 23, 2022, at Levi’s Stadium, the NFC West-leading San Francisco 49ers (3-3) take on the AFC West-leading Kansas City Chiefs (4-2). 

The Chiefs’ most recent game ended in a 24-20 loss against the Buffalo Bills. They will look to bounce back with their potent offense against a tough 49er team. 

The 49ers’ squad hit the road last week in Atlanta but were stunned by the Falcons as the game ended in a 28-14 loss. With both teams looking to rebound, this should be an excellent matchup. 

Let’s take a look at the strengths and weaknesses of both sides and make the best bets for this game.

2022 Chiefs vs. 49ers Game Preview

Chiefs Look to Keep Control of the AFC West

The Kansas City Chiefs are tied for first place in the AFC West with four wins and two losses, but they will look to rebound after falling to the Chiefs at home 24-20. 

Mahomes completed the game with 338 yards passing and two touchdowns but was also picked off twice, including one that was thrown in the end zone early on. JuJu Smith-Schuster recorded five receptions for 113 yards and a score, while the running game managed just 3.3 yards. 

The offense has always been strong for the Chiefs, but the offensive line has been incredibly shaky. The offensive line was expected to be strong in the run game, but something isn’t working there. Overall, the Chiefs rank fourth with 275.8 passing yards per game and are averaging a league-best 29.8 points. 

Kansas City faced the best offense they saw all year and conceded just 24 points. Despite this, they haven’t been playing particularly well, as the unit ranks 20th in total yards allowed (356.5) and 25th in scoring defense (24.8 points allowed per game).

49ers Remain in Tie for First Place in the NFC West

The 49ers are a solid football team, but they have been, unfortunately, ravaged by injuries. Without Nick Bosa and starting linemen Trent Williams and Mike McGlinchy, the 49ers were thrashed on both sides of the ball. Although they remain in a first-place tie in the NFC West, they hope to stop the Chiefs at home and secure a victory.

The Niners’ typically effective running game came to an end last week as Atlanta jumped on the 49ers early. In place of injured starter Elijah Mitchell (knee), Jeff Wilson Jr. had been having a solid season, but he only gained 25 yards on seven attempts, while the ground game totaled 50 total yards. San Francisco finished with fewer than 850 rushing yards in this contest, which was the first time all season.

The 49ers’ defense has been excellent, allowing only 255.8 total yards per game (best). The 49ers’ defense has been instrumental in the team’s success; with 14.8 points allowed per game, they are the second-best in the NFL. The defensive unit has also been fantastic against the pass, as the defense is allowing just 168.3 passing yards allowed per game.

Chiefs vs. 49ers Odds 

The San Francisco 49ers (3-3) and the Kansas City Chiefs (4-2) will square off at Levi’s Stadium, and MyBookie lists the Kansas City Chiefs as -2.5 betting favorites (-110) despite playing on the road. 

The 49ers will be +2.5 (-110) on the spread and +120 on the moneyline in betting underdogs. Meanwhile, the Chiefs are -140 road favorites, with the Over/Under at 48.5 points. 

What’s the Pick?

Ultimately, a furious Patrick Mahomes and a more than adequate receiving group ought to be able to bounce back and succeed in San Francisco. The Chiefs hold one of the best offenses in the league, as they rank first in points per game (29.8). Despite this, they will be playing a defense that ranks first in yards allowed (255.8). 

Expect this game to be a defensive brawl. Neither team will want to give an inch, and they should both play this one safe. The 49ers have started off well, but they were out-hustled by the Atlanta Falcons last week, and they cannot be trusted. 

Patrick Mahomes has not lost to the 49ers once in his career, and the Chiefs have taken four of the last five matchups. Back KC here.

MyBookie Prediction: Kansas City Chiefs -2.5 (-110)

Previous Betting News

With a long offseason, there is a lot of time to talk about what might happen in the coming season in the NFL. You look at how a team finished the season, coaching changes, and the players that were picked up via free agency and the draft to get an idea of how good each team might be. Prior to the start of the season, it was the San Francisco 49ers who were generating the vast majority of the hype given that they finished last season with 5 straight wins with Jimmy Garoppolo under center.

They have not quite lived up the hype through the opening two weeks of the season, with Jimmy G overshadowed by the exploits of Patrick Mahomes in Kansas City. This is the first year as a starter for the young QB, and he has been lights out through those two games. The 49ers and Chiefs will go head to head on Sunday in what could well be a fun game to watch. The Chiefs are in as a 7-point favorite, with the point total set at 55.

2019 49ers vs Chiefs NFL Week 3 Lines & Game Preview

• When: Sunday, Sept 23 at 1 PM EST
• Where: Arrowhead Stadium, Kansas City
• TV: FOX
• Radio: San Francisco / Kansas City 
• NFL Week 3 Lines: Kansas City Chiefs -7 (Total 55)

Weather Forecast

• Clear: 24°C/76°F
• Humidity: 48%
• Precipitation: 0%
• Cloud Cover: 1%
• Wind: 7 mph ESE
• Stadium Type: Open

Why bet on the San Francisco 49ers?

The 49ers had a tough start to the season, opening against the Minnesota Vikings, one of the favorites to win the Super Bowl this year. That game ended with a loss for San Francisco, but they bounced back in Week 2 with a very entertaining 30-27 win over the Detroit Lions. Through those first two games, the 49ers have failed to cover the spread, which has been the trend when they play the Kansas City Chiefs.

While the 49ers have gone 7-3 ATS in their last 10 road games, they have not had the same success at Arrowhead, going just 2-5 ATS in their last 7 games in Kansas City. The 49ers are averaging 23 PPG through their opening two games and are probably going to need to go well beyond that number to keep pace with the high-powered Chiefs offense.

Team Stats

• Average Score For: 23.00
• Total Yards: 336.50
• Rush Yards: 140.00
• Passing Yards: 196.50

• Average Score Against: 25.50
• Total Yards: 385.00
• Rush Yards: 107.00
• Passing Yards: 278.00

Why bet on the Kansas City Chiefs?

While the Chiefs offense has been fun to watch through the opening 2 weeks, they are still having some issues on the defensive side of the football. The Chiefs have racked up 70 points through their first two games, going 2-0 in the process, but they still have some concerns given that their defense has surrendered 65 points in those two games.

You do have to like their chances when playing at home, though, as they have won 18 of their last 24 games at Arrowhead. They have also won 4 of their last 5 home meetings with San Francisco and are 4-2 ATS in their last 6 home games. They will once again be looking to Mahomes to provide the offensive spark, as the young QB has thrown 10 TD passes through his opening two games of the season.

Team Stats

• Average Score Against: 40.00
• Total Yards: 405.5
• Rush Yards: 116.50
• Passing Yards: 289.00

• Average Score Against: 32.50
• Total Yards: 508.00
• Rush Yards: 78.00
• Passing Yards: 430.00

Latest 49ers vs Chiefs NFL Week 3 Betting Trends

• San Francisco is 7-3 ATS in its last 10 games on the road
• San Francisco is 8-17 SU in its last 25 games
• The total has gone OVER in 4 of San Francisco’s last 5 games
• Kansas City is 6-1 ATS in its last 7 games
• Kansas City is 6-1 SU in its last 7 games
• The total has gone UNDER in 5 of Kansas City’s last 5 games at home

Expert Pick & Final Score Prediction

This has the potential to be one of the most entertaining games on the Sunday schedule, and I believe we are going to see some points put up. I am on the Chiefs to win at home in a high-scoring affair.

Score: San Francisco 49ers 27 – Kansas City Chiefs 35

Previous Betting News

Should San Francisco 49ers fans be worried about starting quarterback Jimmy Garoppolo? He has struggled in practice some and looked horrible in his preseason debut last week. Jimmy G returns to the scene of where he tore his ACL last year as the Niners visit the Kansas City Chiefs on Saturday night. The Chiefs are home favorites on the NFL Preseason odds.

How to Bet 49ers vs Chiefs 2019 NFL Preseason Week 3 Odds & Game Info

• When: Saturday, 8 PM ET
• Where: Arrowhead Stadium
• TV: NFL Network replay
• NFL Odds: Kansas City Chiefs -3.5 (Total 45)

Last meeting

These teams played Week 3 of the 2018 regular season and Kansas City won 38-27 – the Niners’ season went down the tubes when star QB Jimmy Garoppolo left late in the fourth quarter after his left knee buckled during a scramble to the sideline. He was crushed on his throwing shoulder by the Chiefs’ Steven Nelson.

Jimmy G could have just run out of bounds and avoided contact. He tore his ACL. Patrick Mahomes threw for 314 yards and three scores for Kansas City. Kareem Hunt ran for two scores, but he’s gone now.

Weather Forecast

• Cloudy: 24°C/76°F
• Humidity: 67%
• Precipitation: 24%
• Cloud Cover: 86%
• Wind: 11 mph ESE
• Stadium Type: Open

Why Bet on San Francisco?

The Niners are 2-0 this preseason, but there was one major worry sign in last week’s 24-15 win over Denver. Jimmy Garoppolo went just 1-for-6 for zero yards and an interception in his first game since he suffered that knee injury against the Chiefs.

Garoppolo finished the night with a 0.0 passer rating. If you just take a snap without fumbling, you have a higher rating than that. Garoppolo’s first pass was knocked down by defensive lineman Shelby Harris and his second one was intercepted by cornerback Isaac Yiadom when he was pressured. Jimmy G played two series.

“You always want to play better. But to get concerned over 10 plays, that’s pretty irresponsible,” coach Kyle Shanahan said. “What stinks is when you go out there and you just get a few opportunities and it doesn’t go right and you’re not in a position to play yourself out of it.

Dante Pettis and Marquise Goodwin played all 11 snaps with the first-team offense in Monday night’s win over the Broncos. Jordan Matthews played five snaps, and the other Niners receivers were in on zero downs with the Garoppolo group. There’s been a ton of talk about Pettis losing his starting job with a lackluster summer in practice, but apparently that’s not true. Tailback Raheem Mostert was impressive in the win, rushing six times for 58 yards and a touchdown, and adding two catches for 42 yards.

Fellow running back Jerick McKinnon remains limited to individual drills in practice. McKinnon is about three weeks removed from undergoing a PRP injection in his surgically-repaired knee. He was a big free-agent signing last year but never played a regular-season down due to that injury.

The big question on this team is who the backup QB is: C.J. Beathard and Nick Mullens have rotated starts throughout the first two preseason contests, but it’s not yet clear on which will be the first off the bench during Saturday’s game.

Team Stats (Offense)

• Points per Game: 15.14
• Passing Yards: 179.71
• Rushing Yards: 130.29
• Turnovers: 1.29

Why Bet on Kansas City?

The Chiefs are 1-1 this preseason after losing 17-7 last week in Pittsburgh. Patrick Mahomes didn’t play much and completed 2-for-5 for 11 yards in two series. Chad Henne found Mecole Hardman for a 17-yard touchdown late in the first half for Kansas City, which managed a lone touchdown a week after putting up 38 against the Bengals. Hardman, a second-round pick, has two touchdowns in two weeks.

Rookie quarterback Kyle Shurmur and second-year signal caller Chase Litton handled the second half of action for Kansas City under center, with Shurmur completing 3-of-7 passes for 22 yards while Litton connected on 10-of-17 for 94 yards. Rookie wide receiver Cody Thompson led all pass-catchers with seven grabs for 69 yards on the night.

Safety and new addition Tyrann Mathieu left the game with a minor shoulder injury. He came off the field after playing just three snaps. The Chiefs called his exit “precautionary” while coach Andy Reid thinks the Honey Badger will play this week. His early departure Saturday afforded more snaps to second-round rookie Juan Thornhill, who impressed with three tackles and a pass breakup.

After signing with the Chiefs, cornerback Morris Claiborne didn’t suit up and play in preseason Week 2. That seemed to be the plan, according to Andy Reid, but Claiborne was never formally ruled out. However, according to defensive coordinator Steve Spagnuolo, Claiborne could be making his Chiefs debut against the 49ers.

The coaching staff finds themselves doing the balancing act, knowing that Claiborne can’t play in the first four regular-season games because of a suspension, but also knowing that they need to see where he fits in this defense. With the starting defense expected to play for three quarters, he might not see much playing time in this one.

Team Stats (Offense)

• Points per Game: 27.29
• Passing Yards: 220.43
• Rushing Yards: 111.71
• Turnovers: 0.57

49ers vs Chiefs NFL Preseason Week 3 Betting Trends

• 49ers are 6-1 ATS in their last 7 Saturday games
• 49ers are 1-10 SU in their last 11 games on the road
• The total has gone OVER in 4 of San Francisco’s last 5 games when playing on the road against Kansas City
• Chiefs are 2-5 ATS in their last 7 home games
• Chiefs are 2-6 SU in their last 8 games against an opponent in the NFC West division
• The total has gone OVER in 7 of Kansas City’s last 10 games

Expert Final Score Prediction for 49ers vs Chiefs

San Francisco 49ers 20 – Kansas City Chiefs 27