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Next Thursday, MLB throws first pitch for their 2022 season. Although the season suffered a delay due to the MLB lockout, things are copasetic as we head into April. Because the season starts soon, it makes sense for us to make predictions. Check out MLB Betting predictions for both the American League and National League as well as a World Series predicted matchup and choice to win.

MLB 2022 Picks & Season Betting Predictions Before It Starts

2022 MLB Season: April 7 – Oct. 5

AL Pennant Winner – Houston Astros +370

Carlos Correa vaulted to Minnesota, but the Houston Astros remain the top team to win the American League. The main reason is because the AL West is the worst division in baseball.

The Angels will be an okay team. The A’s and Mariners won’t. Neither will the Rangers. So Houston is almost guaranteed to win their division. Also, the starting rotation becomes the best in baseball if Justin Verlander returns to his top form.

AL Cy Young Winner – Lucas Giolito, Chicago White Sox +1100

This is an odds play. Gerrit Cole’s odds make him an underlay. Nobody knows for sure if Chris Sale returns to his best form.

Nobody knows if Shohei Ohtani maintains his brilliance on the mound and Tampa’s Tyler Glasnow may or may not be as good before the injury. Giolito offers decent odds, gets some protection in the rotation because Lance Lynn is also an ace, and should peak this season.

AL MVP – Mike Trout, Los Angeles Angels +1900

Trout missed a lot of time last season. This season, the Angels best player is flying under the radar because Ohtani was so brilliant.

The thing about Trout, though, is that he’s been dominant for years. So at the odds, he’s the best play to once again prove why some place him on the same level as the best in MLB history.

NL Pennant Winner – Los Angeles Dodgers +200

The Dodgers offer underlay odds every season to win the NL Pennant. This season, though, the odds make LAD a fair choice.

Sure, the rotation lost Max Scherzer. But Walker Buehler is ready to take over as the ace. Not only that, with every passing day, it’s apparent Trevor Bauer won’t have to sit out the season.

Also, Clayton Kershaw is back and, this is the most important part, the Dodgers signed Freddie Freeman away from the defending champion Atlanta Braves.

Unless Dave Roberts blows it with bad managerial decisions in the NLCS, LAD should win the National League.

NL Cy Young Winner – Corbin Burnes, Milwaukee Brewers +1100

Burnes won the Cy Young last year. Pitchers don’t often win the Cy Young two seasons in a row, but Burnes offers the fairest odds.

It’s tough to back Scherzer even though he gets some cover playing behind the chalk, Jacob deGrom. It’s tough to back deGrom because he’s got a history of injuries and it’s tough to back Buehler because this is the first time he’s the Dodgers’ unquestioned ace. Burnes gets the nod.

NL MVP – Bryce Harper, Philadelphia Phillies +900

This is another odds play. Last season, Bryce Harper proved he’s the best player in the National League. There’s no reason to believe Harper lets up in 2022.

More importantly, contenders like Freddie Freeman and Ronaldo Acuna Jr. offer odds that make them close to unplayable. Harper’s odds make him a slight overlay.

2022 World Series Winner – Houston Astros +880

In a battle between the Los Angeles Dodgers and Houston Astros, the Stros should take the series. If Verlander has his best pitches working, Houston has the better starting rotation. The Stros lineup is as solid as the Dodgers’.

But more important than that, Dave Roberts, almost without fail, will make a couple of bad decisions, like using a starter longer than he should in relief or putting his closer in to start the 8th inning in Game 6.

Dusty Baker will out manage Dave Roberts and that’s why the Astros will beat the Dodgers and win the World Series.

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World Series: Top odds up to moment to win the 2020 World Series

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The Los Angeles Dodgers remain the +280 betting favorites to win the World Series at Mybookie.ag, and they should be. However, suddenly the New York Yankees do look like legitimate contenders to perhaps beat the Dodgers in the Fall Classic. New York is the MLB favorites.

How to Bet World Series

The Yankees will be well-rested for the start of their American League Division Series on Monday against Tampa Bay (+370 to win World Series) as the Bombers finished off the Indians in a two-game sweep in Cleveland on Wednesday night. The Yankees scored 22 total runs and hit seven homers in the two games. Those were the most runs scored and most homers all-time through a team’s first two games of a postseason.

New York won a wild game Wednesday 10-9 — DJ LeMahieu’s RBI single was the first go-ahead hit in the 9th inning or later of a postseason game for the Yankees since Raúl Ibañez hit a walk-off home run in Game 3 of the 2012 ALDS against the Orioles. LaMahieu led the majors in batting this season.

The poor Indians have now lost 10 straight elimination games, the longest streak in postseason history. In fact, the two longest streaks were both extended on Wednesday as the Twins lost their 9th straight elimination game dating back to 2002.

We liked the Twins to come out of the American League but they have now lost an unthinkable 18 straight playoff games, the longest such streak in North American sports history. Minnesota still has not won a playoff game since Game 1 of the 2004 ALDS. The thing is, the Twins easily could have won both games against Houston but kept making boneheaded mistakes.

In Game 1, shortstop Jorge Polanco had a terrible error in the ninth inning – had his throw been accurate, the Twins come up in the bottom of the ninth with a chance to win. Instead, Houston scored three runs after the error.

In Game 2, Twins outfielder Eddie Rosario was ejected after taking issue with a 3-1 pitch in the bottom of the sixth inning that appeared to be above the zone and got tossed by home plate umpire Manny Gonzalez when he struck out on a foul tip moments later. Minnesota already was short on outfielders with Byron Buxton sidelined due to injury. Just a stupid, stupid thing by Rosario.

Nobody on the 2020 Twins team had a hand in more than six of the playoff losses, but for the second consecutive year one of baseball’s most potent lineups limped through a brief postseason cameo. In a three-game division series sweep by the Yankees last year, the Twins totaled seven runs and 22 hits. Against the Astros, they mustered only two runs and seven hits.

Tampa Bay, meanwhile, is now the +370 third-favorite to win the World Series after easily sweeping aside the Blue Jays in the Wild Card round on Wednesday. Designated hitter Randy Arozarena, in his first full season with Tampa Bay, was the offensive catalyst for the lineup in the team’s first two games this postseason, collecting three hits and scoring two runs in Wednesday’s series-clinching win against Toronto.

“We’ve been confident since Day One. So if we put our heads down and just do what we’ve been doing and prepare like we’ve been preparing, the sky’s the limit,” winning pitcher Tyler Glasnow said.

It was a disappointing finish for Toronto, which overcame a slow start to make a surprising run to its first playoff berth since 2016 with a roster featuring 19 players without previous major league playoff experience, including Cavan Biggio, Bo Bichette and Vladimir Guerrero Jr. The Blue Jays should be very good next season.

Even though the Rays finished seven games ahead of the Yankees in the AL East, New York will be the ALDS favorite. That best-of-5 series will be played at neutral-site Petco Park in San Diego.

The Houston Astros also swept in the AL Wild-Card round and are +1200 to win their second World Series since 2017. After winning 101, 103 and 107 games in the past three regular seasons, winning the 2017 Fall Classic and losing the championship in seven games to the Washington Nationals last year, the Astros stumbled through the 2020 season at 29-31 under manager Dusty Baker. They had the third-worst road record in the major leagues, too, but won both games at Minnesota.