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The Los Angeles Chargers head up the Pacific Coast Highway to Santa Clara on Sunday to take on the San Francisco 49ers. The Chargers and 49ers are in the thick of the playoff chase. Neither team wants to take a backward step by losing. Heading into the contest, the Chargers are a big time +7 underdog. Will the Niners cover on their field? Or will Los Angeles do enough to keep the score within the spread line? See below for NFL Odds, analysis, and a free pick for Chargers at 49ers.

NFL Week 10 Betting Preview for Los Angeles Chargers at San Francisco

Thursday Night Football: Chargers versus 49ers Odds and Match Info

When: Sunday, Nov. 13 at 8:20 pm ET
Where: Levi’s Stadium, Santa Clara, CA
TV / Streaming: NBC / Peacock
ATS Odds: 49ers -7
Money line Odds: Chargers +250 / 49ers -311
Over/Under Odds: 45.5

Why bet on Chargers versus 49ers?

In NFL Week 7, the Bolts lost to the Seattle Seahawks. It turns out that the Seahawks are one of the NFL’s top teams. Seattle has the NFC West lead and Geno Smith is playing great football.

After falling to the Hawks, the Chargers took week 8 off. Last Sunday, LAC struggled for most of the game, but when it mattered most, the Bolts stepped it up, beating the Atlanta Falcons 20-17 on the road.

The Chargers’ have grit. The team won’t quit. On paper, LAC shouldn’t win SU or cover ATS. But the Bolts’ toughness could carry them through to at least a cover victory.

Los Angeles Chargers Offensive Averages

Total Yards: 364.3

Passing Yards: 275.1

Rushing Yards: 89.1

Points Scored: 23.0

Turnovers: 9

Los Angeles Chargers Defensive Averages

Total Yards: 352.3

Passing Yards: 206.8

Rushing Yards: 145.5

Points Scored: 25.8

Takeaways: 9

Why bet on 49ers versus Chargers?

In week 7, Kansas City embarrassed the San Francisco 49ers, dusting Jimmy G. and his mates 44-23. The Niners had every reason to give up in the NFL Week 8 game after such a devastating loss.

Instead of giving up, SF dominated the rival Rams 31-14. San Francisco showed they have what it takes to beat a quality opponent. Not only that, but this game happens after San Francisco’s bye in NFL Week 9.

San Francisco 49ers Offensive Averages

Total Yards: 356.6

Passing Yards: 237.1

Rushing Yards: 119.5

Points Scored: 22.0

Turnovers: 12

San Francisco 49ers Defensive Averages

Total Yards: 285.9

Passing Yards: 199.3

Rushing Yards: 86.6

Points Scored: 18.4

Takeaways: 7

Chargers at 49ers Relevant Trends

Chargers are 4-0 ATS in their last 4 on the road
LAC is 2-10 ATS in their last 12 games in November
Over is 10-4 in the Chargers last 14 games
49ers are 6-1 ATS in their last 7 at home
San Francisco is 6-1 ATS versus a team with a winning record
Under is 5-1 ATS in the 49ers’ lat 6 following an ATS win

Los Angeles Chargers at San Francisco 49ers Final Betting Prediction

7 points is a lot because the Bolts are a quality squad. But Los Angeles got lucky against Atlanta last Sunday. The Falcons should have won the game outright or at least taken the contest into overtime.

On Sunday, Justin Herbert and his mates face the top-ranked defense in yards allowed per game. The 49ers hold opponents to less than 286 total yards per, which means Herbert and the Chargers’ O will struggle.

Also, the Bolts defense is going to have an impossible time stopping San Francisco running back Christian McCaffrey. The Chargers allow over 145 rushing yards per game.

McCaffrey averages 5.1 yards per carry and is a massive threat in the passing game. San Francisco should have no trouble covering the spread.

NFL Week 10 Pick: San Francisco 49ers -7