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On Nov. 25, Buffalo and New Orleans battle in the NFL’s Thanksgiving Thursday nightcap. When the game kicks off, both the Bills and Saints will be searching for victories. New Orleans is desperate to end a 3-game losing streak. Buffalo is in a fight with New England for the AFC East Division title. Which team gets it done? Keep reading for NFL odds, analysis, and a free pick for Buffalo at New Orleans.

NFL Betting Preview for Buffalo Bills at New Orleans

Buffalo Bills vs New Orleans Saints Game Odds & Info | NFL Week 12 Betting

When: Thursday, Nov. 25 at 8:20 pm ET
Where: Caesars Superdome, New Orleans, LA
TV / Streaming: NBC / Peacock
ATS Odds: Buffalo -4 ½
Moneyline Odds: Buffalo -210 / New Orleans +175
Over/Under Odds: 46

Why bet on Buffalo versus New Orleans?

Alhtough Indianapolis trounced Buffalo in the Bills’ Week 11 game, Buffalo’s defense is much better than it showed. On average, teams score just 17.6 points per versus Buffalo’s D. On offense, Buffalo has the ultimate weapon in quarterback Josh Allen. Allen can rush through linebackers and safeties. Or he can sit in the pocket and throw darts. Either way, he gives the Bills an offensive edge in this.

Buffalo Bills Offensive Averages

Total Yards: 391.7

Passing Yards: 272.9

Rushing Yards: 118.8

Points Scored: 29.5

Turnovers: 14

Buffalo Bills Defensive Averages

Total Yards: 283.7

Passing Yards: 181.58

Rushing Yards: 101.9

Points Scored: 17.6

Takeaways: 22

Why bet on New Orleans versus Buffalo?

The Saints are in desperation mode. New Orleans has lost 3 straight for the first time in what seems like forever. Sean Payton is a master strategist, which means he’ll pull out all the stops to ensure New Orleans gets a victory in this. Not only that, but although the Saints are struggling, they’re just 2 games behind the Buccaneers for the NFC South lead. New Orleans will be motivated.

New Orleans Saints Offensive Averages

Total Yards: 321.3

Passing Yards: 203.4

Rushing Yards: 117.9

Points Scored: 25.1

Turnovers: 11

New Orleans Saints Defensive Averages

Total Yards: 342.0

Passing Yards: 252.2

Rushing Yards: 89.8

Points Scored: 21.8

Takeaways: 14

Bills at Saints Relevant Trends

Bills are 3-0-1 ATS in their last 4 games following a straight up loss
Buffalo is 7-3 ATS in their last 10 road games
Under is 8-1 in the Bills’ last 9 games following a straight up loss
Saints are 6-0 ATS in their last 6 games following a straight up loss
New Orleans is 5-2 ATS in their last 7 games on a Thursday
Under is 8-0-1 in the Saints’ last 9 games on a Thursday

Buffalo Bills at New Orleans Saints Final Betting Prediction

There’s a good chance dual-threat quarterback Taysom Hill, who just signed a contract that could be worth up to $95 million, gets the start at quarterback. Hill is one of the most unique QBs in the league.

The Saints must do something to end the losing streak and although Trevor Siemian hasn’t been terrible, he hasn’t played great, either. Payton won’t wait. He knows New Orleans can’t afford to lose a fourth in a row.

Even if Hill doesn’t start, the Saints are a good moneyline play. Most believe Buffalo is the better team. But the Bills have lost 2 of their last 3 road games straight up. One of the road losses was to the terrible Jacksonville Jaguars.

Jalen Hurts and the Eagles thrashed the Saints’ D in Week 11. New Orleans’ defense should play much better on Thursday night. Not only that, but the Colts exposed the Bills’ rush defense in Indy’s impressive 41-15 victory.

Buffalo won’t bounce back so quickly after such a tough loss. This game can go either way, which is why backig the home team on the moneyline makes the most sense.

NFL Week 12 Pick: New Orleans Saints moneyline

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