Vikings vs Bills Odds, Analysis & Prediction - NFL Week 10 Lines

Two of the National Football League’s best teams this season clash on Sunday when the Minnesota Vikings travel to Highmark Stadium in Orchard Park, New York to take on the Buffalo Bills. Minnesota heads to Buffalo on a sweet winning streak. The Bills hope to get back on the right track after losing their last game to the rival New York Jets. Will Josh Allen and his mates get it done? Or will Kirk Cousins and his team pull off the upset win? Keep reading for NFL Odds, analysis, and a free pick for Vikings at Bills.

NFL Week 10 Betting Preview for Minnesota Vikings at Buffalo

Sunday Night Football: Minnesota Vikings versus Buffalo Bills Lines and Match Info

When: Sunday, Nov. 13 at 8:15 pm ET
Where: Highmark Stadium, Orchard Park, NY
TV / Streaming: FOX / Fox Sports
ATS Odds: Buffalo -3.5
Money line Odds: Minnesota +155 / Buffalo -191
Over/Under Odds: 43.5

Why bet on Minnesota versus Buffalo?

NFL handicappers keep doubting the Vikings. Minnesota’s response has been to continue to win games.

The Vikings head to Buffalo with a fantastic 7-1 record. The only team to have beaten Minnesota is undefeated Philadelphia. The Eagles victory happened back in week 2.

Since then, the Norsemen have won 6 straight. Not only has Minnesota won, but they’ve also covered, going 2-0-1 against the spread in their last 3.

Minnesota Vikings Offensive Averages

Total Yards: 340.1

Passing Yards: 238.1

Rushing Yards: 102.0

Points Scored: 24.1

Turnovers: 8

Minnesota Vikings Defensive Averages

Total Yards: 368.1

Passing Yards: 256.9

Rushing Yards: 111.3

Points Scored: 20.1

Takeaways: 12

Why bet on Buffalo versus Minnesota?

Buffalo has rolled through their competition, including beating Kansas City and Green Bay in back-to-back games, but in their last, the Jets handed the Bills their second loss of the season.

In 2022, though, NYJ is a solid team. The Jets have a good defense and a great offense. So we should forgive Buffalo for losing after a couple of tough victories in a row.

Now back on their field, the Bills should go back to beating up opponents. Buffalo averages more yards per game than any other team. The Bills rank third in points per game and the Vikings defense doesn’t always play at a high level.

Buffalo Bills Offensive Averages

Total Yards: 416.4

Passing Yards: 292.1

Rushing Yards: 124.3

Points Scored: 27.5

Turnovers: 14

Buffalo Bills Defensive Averages

Total Yards: 299.6

Passing Yards: 194.8

Rushing Yards: 104.9

Points Scored: 14.8

Takeaways: 13

Vikings at Bills Relevant Trends

Vikings are 1-3-1 ATS in their last 5 on the road
Minnesota is 0-4 ATS in their last 4 games after allowing less than 150 yards passing in their previous game
Over is 5-1 in the Vikings’ last 6 road games versus a team with a winning home record
Buffalo is 5-1-1 ATS in their last 7 home games
Bills are 11-4-1 ATS in their last 16 games in November
Under is 6-0 in the Bills last 6 games

Minnesota Vikings at Buffalo Bills Final Betting Prediction

The team you decide to back against the spread depends on how you feel about the Minnesota Vikings. We know the Bills are a quality team.

The jury on the Vikings, even though it’s week 10, is still out. Minnesota got lucky in wins against New Orleans, Miami, the Dolphins were without Tua, and Washington last Sunday.

Also, two Sunday’s ago, the Vikings allowed Cardinals’ quarterback Kyler Murray to throw for 326 yards. Josh Allen averages 300 passing yards a game.

In addition, Buffalo fields the best defense the Vikings have faced this season. Any way we cut it, we come to the same conclusion, the Vikings are in trouble. Buffalo wins and covers.

NFL Week 10 Pick: Buffalo Bills -3.5