The Indianapolis Colts are set to take on the Jacksonville Jaguars in a Week 6 affair to determine who is at the top of the AFC South.
The Indianapolis Colts are 3-2 coming off their 23-16 win over the Tennessee Titans last week. The Jaguars beat the Colts back in the opening week of the season.
For Jacksonville, they are 3-2, after back-to-back wins in London. The Jaguars beat the Falcons and then the Bills. The Jaguars are favorites at home in this game. Jacksonville is listed at -4 over the Colts.
MyBookie offers the game prediction plus NFL odds, analysis, along with a free pick for Indianapolis Colts versus the Jacksonville Jaguars which are playing on Week 6 of the season.
Colts vs Jaguars Betting Prediction: Get Your NFL Odds for the Game | MyBookie NFL Week 6 Regular Season Preview
Indianapolis Colts vs Jacksonville Jaguars | NFL Week 6
ATS: Jaguars -4
Money line: Colts +167 / Jaguars -207
Over/Under: 45.5
Sunday, October 15th, 2023 at 1:00 pm ET | CBS
EverBank Stadium, Jacksonville, FL
Minshew Leading Charge
The Colts got terrible news: rookie quarterback Anthony Richardson will miss 4-8 weeks with a shoulder injury. Now, it’s Gardner Minshew in to run the offense.
Minshew has already played several times this season and thrown 83 passes, two of them for touchdowns. He has yet to throw an interception on the season. Michael Pittman is his top target, with 31 receptions, 297 yards, and a touchdown.
Jonathan Taylor is back for the Colts, but in his debate, he only carried the ball six times for 18 yards. Zack Moss has been the man at running back. Moss has 445 yards and three touchdowns on the ground, while another one via the air.
The Colts are rushing for 131.2 yards per game on the ground, which ranks 8th in all of the National Football League.
Indianapolis has this game and then will go back home for back-to-back games with the Browns and Saints coming to town.
Jaguars Want to Ride Momentum
The Jacksonville Jaguars would love to ride the momentum they got while playing in London. The Jaguars beat the Falcons and Bills by a combined score of 48-27.
Jacksonville is figuring things out, many things that led them to win the AFC South a season ago. The offense for the Jaguars goes through Trevor Lawrence. The signal-caller has completed 121 of 180 passes for 1,258 yards and five touchdowns.
Christian Kirk, Evan Engram, and Calvin Ridley are the top three targets in the passing game. Kirk leads with 335 yards, while Ridley has the most touchdowns with two. Travis Etienne had one of the best games of his season against the Bills, as he carried the ball 26 times for 136 yards and two touchdowns.
The Jaguars will play back-to-back road games following this game and then have Week 9 off. Jacksonville is at the Saints and Steelers.
First Meeting
As we mentioned in the first meeting, the Jaguars beat the Colts 31-21. In that game, Calvin Ridley caught the first touchdown pass of the game, with Zay Jones catching one later. Both Tank Bigsby and Travis Etienne rushed for a touchdown in the fourth quarter to seal the deal.
For Indianapolis, Anthony Richardson threw for 223 yards and a touchdown while rushing for an additional 40 and a score. The Colts led the game 21-17 after three quarters but failed to score in the fourth.
Colts vs Jaguars Betting Prediction | Jaguars Win and Cover at Home
There is no doubt that the Colts are going to want revenge, but can they get it? Sure, the Colts have had the Jaguars number over the years, but Jacksonville is playing better football.
The Jaguars are moving the ball, and the defense has settled in. Minshew is one of the better starting quarterbacks in all of the National Football League, but this will be a challenge for him.
We like the Jacksonville Jaguars to win this game and cover the spread in a big divisional battle. Betting the Jacksonville Jaguars -4 is the play here.
NFL Week 5 Pick: ATS Jaguars -4 | Bet Colts vs Jaguars
MyBookie Betting Lines for the Game
Indianapolis Colts Last 5
| Date | OPP | Result |
|---|---|---|
| 10/8/23 | vs TEN | W23-16 |
| 10/1/23 | vs LAR | L29-23 OT |
| 9/24/23 | @ BAL | W22-19 OT |
| 9/17/23 | @ HOU | W31-20 |
| 9/10/23 | vs JAX | L31-21 |
Indianapolis Colts Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Mo Alie-Cox TE | Questionable | Oct 8 |
| Shaquille Leonard LB | Questionable | Oct 10 |
| Kwity Paye DE | Questionable | Oct 10 |
| Bernhard Raimann OT | Questionable | Oct 10 |
| Anthony Richardson QB | IR | Oct 11 |
AFC South Standings | Indianapolis Colts
| Team | W | L | T | Strk |
|---|---|---|---|---|
| Jacksonville Jaguars | 3 | 2 | 0 | W2 |
| Indianapolis Colts | 3 | 2 | 0 | W1 |
| Houston Texans | 2 | 3 | 0 | L1 |
| Tennessee Titans | 2 | 3 | 0 | L1 |
Jacksonville Jaguars Last 5
| Date | OPP | Result |
|---|---|---|
| 10/8/23 | vs BUF | W25-20 |
| 10/1/23 | vs ATL | W23-7 |
| 9/24/23 | vs HOU | L37-17 |
| 9/17/23 | vs KC | L17-9 |
| 9/10/23 | @ IND | W31-21 |
Jacksonville Jaguars Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Walker Little OT | Questionable | Oct 9 |
| Cam Robinson OT | Questionable | Oct 9 |
| Christian Braswell CB | Questionable | Oct 10 |
| Devin Lloyd LB | Questionable | Oct 10 |
| Zay Jones WR | Questionable | Oct 11 |
NFL Betting Odds
Indianapolis Colts
Super Bowl Odds to Win: +10000
AFC South Odds to Win:
+5400
Jacksonville Jaguars
Super Bowl Odds to Win: +19000
AFC South Odds to Win: +1250
Indianapolis Colts at Jacksonville Jaguars Betting Trends
- Jacksonville has one win against the spread, and is 1-2 overall, at home this year.
- The Jaguars have gone 3-2-0 against the spread this season.
- At home, Jacksonville is winless ATS (0-1) as 4-point favorites or more.
- The Jaguars have not covered a spread (0-1) when they are at least 4-point favorites.
- Jacksonville has gone over the total once in three home games this year.
- Jaguars games have gone over the total twice this season.
- The Colts are 6-1 SU and 5-2 ATS in their last seven games against the Jaguars.
- The total has gone under in eight of the Colts’ last 10 games against the Jaguars.
- The Jaguars are 0-5 SU in their last five games against teams with losing records.
- The Jaguars are 2-22 SU in their last 24 games on the road.
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| Kansas City Chiefs | +480 |
| San Francisco 49ers | +520 |
| Baltimore Ravens | +930 |
| Philadelphia Eagles | +960 |
| Detroit Lions | +990 |
| Buffalo Bills | +1175 |
| Houston Texans | +1300 |
| Dallas Cowboys | +1475 |
| New York Jets | +1475 |
| Cincinnati Bengals | +1625 |
| Miami Dolphins | +2300 |
| Atlanta Falcons | +2900 |
| Los Angeles Rams | +3000 |
| Chicago Bears | +3100 |
| Green Bay Packers | +3100 |
| Los Angeles Chargers | +3200 |
| Cleveland Browns | +3900 |
| Pittsburgh Steelers | +4100 |
| Jacksonville Jaguars | +4500 |
| New Orleans Saints | +4900 |
| Minnesota Vikings | +5400 |
| Seattle Seahawks | +5800 |
| Tampa Bay Buccaneers | +6200 |
| Indianapolis Colts | +8000 |
| Las Vegas Raiders | +9000 |
| Arizona Cardinals | +11000 |
| Washington Commanders | +13000 |
| Denver Broncos | +14000 |
| New England Patriots | +14000 |
| Tennessee Titans | +16000 |
| New York Giants | +17000 |
| Carolina Panthers | +40000 |
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