49ers vs Cardinals Lines & Picks - NFL Week 11 Odds for MNF

Rivals San Francisco and Arizona head to Mexico on Monday night moving in opposite directions. The 49ers remain one of the favorites to win the Super Bowl while AZ knows that a loss on Nov. 21 could end their playoff hopes. Check out most updated NFL Betting Odds, analysis, and a free pick for SF versus Zona.

NFL Week 11 Betting Preview for San Francisco 49ers at Arizona

Monday Night Football: San Francisco 49ers vs Arizona Cardinals Odds and Match Info

When: Monday, Nov. 21 at 8:15 pm ET
Where: Estadio Azteca, Mexico City, Mexico
TV / Streaming: ESPN / ESPN+
ATS Odds: San Francisco -10
Money line Odds: San Francisco -500 / Arizona +375
Over/Under Odds: 43

Why bet on San Francisco versus Arizona?

After a pair of let down performances, 28-14 versus Atlanta and an inexplicable 44-23 loss to Kansas City, the Niners have bounced back with two terrific wins.

San Francisco beat the Rams 31-14 and then in their last, the 49ers beat the Los Angeles Chargers 22-16. The quality wins point to the 49ers getting back on the right track.

San Francisco 49ers Offensive Averages

Total Yards: 360.8

Passing Yards: 236.3

Rushing Yards: 123.7

Points Scored: 22.0

Turnovers: 13

San Francisco 49ers Defensive Averages

Total Yards: 280.6

Passing Yards: 197.9

Rushing Yards: 82.7

Points Scored: 18.1

Takeaways: 8

Why bet on Arizona versus San Francisco?

Like SF, Zona has dropped two straight: 34-26 against Minnesota, and 31-21 versus Seattle. Also like the Niners, the Cards bounced back with a sweet victory.

Arizona beat the rival Los Angeles Rams 27-17 in their last. Zona’s performance proved that both the defense and the offense were good enough to hang with quality teams.

If Zona has momentum, they should have a great shot because they’ll have plenty of fans rooting for them at Estadio Azteca.

Arizona Cardinals Offensive Averages

Total Yards: 333.7

Passing Yards: 220.6

Rushing Yards: 113.1

Points Scored: 23.0

Turnovers: 9

Arizona Cardinals Defensive Averages

Total Yards: 357.6

Passing Yards: 247.1

Rushing Yards: 110.5

Points Scored: 25.8

Takeaways: 14

49ers at Cardinals Relevant Trends

49ers are 9-2 ATS in their last 11 vs. the NFC
San Francisco is 5-2 ATS versus a team with a losing record
Under is 10-2 in the 49ers last 12 games on grass
Cardinals are 7-1-1 ATS in the last 9 meetings
Arizona is 2-9 ATS in their last 11 Monday games
Over is 4-0 in the Cardinals’ last 4 games

San Francisco 49ers vs Arizona Cardinals Final Betting Prediction

The spread is massive because most believe Kyler Murray sits on the bench. Murray got hurt in the win over the Rams. Without Murray, Arizona’s offense won’t be as effective.

But Kyler doesn’t play defense and The Valley’s D looked great in the win over the Rams in NFL Week 10. Almost as important?

Colt McCoy knows the offense and the Cardinals list the journeyman QB as probable. Murray is questionable.

In addition, San Francisco’s offense plays slow, which means they may not have enough possessions to push this past 10 points. All Colt or Kyler must do is keep this to within a TD and AZ backers score a victory.

NFL Week 11 Pick: Arizona Cardinals +10