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Two teams looking to turn their seasons around before the mid-point step onto the field at Levi’s Stadium on NFL Sunday Night Football. The Indianapolis Colts hope they can carry momentum from an NFL Week 6 victory into SF while the 49ers want to win the first game after their bye. Which team gets it done? Keep reading for NFL odds, analysis, and free picks for Colts versus 49ers.

NFL Betting Preview for Indianapolis Colts vs San Francisco 49ers

NFL Week 7: Indianapolis at San Francisco Game Odds & Info

When: Sunday, Oct. 24 at 8:20 pm ET
Where: Levi’s Stadium, Santa Clara, CA
TV / Streaming: NBC / Peacock
ATS Odds: San Francisco -4
Moneyline Odds: Indianapolis +175 / San Francisco -210
Over/Under Odds: 44

Why bet on Indianapolis versus San Francisco?

A couple of weeks ago, the Colts had the Baltimore Ravens on the ropes. If not for an unbelievable overtime comeback win orchestrated by Lamar Jackson, Indianapolis would head into San Francisco at 3-3 instead of 2-4. Even after the disappointing loss, Indianapolis came back the very next week and trounced Houston 31-3. The Colts are playing well enough to take this on the moneyline.

Indianapolis Colts Offensive Averages

Total Yards: 5
Passing Yards: 3
Rushing Yards: 2
Points Scored: 2
Turnovers: 5

Indianapolis Colts Defensive Averages

Total Yards: 5
Passing Yards: 5
Rushing Yards: 0
Points Scored: 8
Takeaways: 12

Why bet on San Francisco versus Indianapolis?

After starting the season 2-0, the 49ers lost 3 straight, which is why SF’s bye came at the perfect time. San Francisco lost all three games to quality teams. Russell Wilson played in the loss to Seattle. The other two losses happened against, arguably, the best two teams in the NFC, the Green Bay Packers and the Arizona Cardinals. Indianapolis is a good team, but SF takes them on after a bye. The 49ers are healthier and know they must win this game.

San Francisco 49ers Offensive Averages

Total Yards:2
Passing Yards: 2
Rushing Yards: 0
Points Scored: 4
Turnovers: 7

San Francisco 49ers Defensive Averages

Total Yards: 8
Passing Yards: 6
Rushing Yards: 2
Points Scored: 8
Takeaways: 2

Colts at 49ers Relevant Trends

Colts are 4-1 ATS in their last 5 games
Indianapolis is 7-2 ATS in their last 9 road games
Over is 5-1 in the Colts’ last 6 games
49ers are 1-5 ATS in their last 6 on the road
San Francisco is 1-4 ATS in their last 5 games
Under is 5-0 in 49ers’ last 5 games following a bye week

Indianapolis Colts versus San Francisco 49ers Final Betting Prediction

San Francisco may be healthier, but the 49ers were so banged up before their bye, being healthier doesn’t mean much. Not only that, but Jimmy Garoppolo is listed as probable.

Probable means Jimmy G. should play. It also means he may not be as effective as he normally is. More importantly, whether Garoppolo plays or not, the Niners will have a difficult time stopping Indy’s offense.

Carson Wentz has found his groove. The former Philadelphia Eagles player has thrown 9 TDs to just 1 pick this season. He’s completing over 64% of his passes.

If San Francisco decides to key on Wentz, they must deal with running back Jonathan Taylor, who has scored 5 combined touchdowns and averages 5.4 yards per carry. Anyway we look at it, Indianapolis has every advantage except homefield.

The Colts are on a roll while San Francisco has struggled. Indianapolis should win this straight up.

NFL Week 7 Pick: Indianapolis Colts moneyline

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