2024 Lions vs. Cardinals Pick: NFL Las Vegas Betting Line

As two 1-1 teams gear up for an electrifying Week 3 showdown, the NFL Las Vegas betting line sets the stage for the Detroit Lions’ clash with the Arizona Cardinals, who recently bounced back from a tough loss to the Buffalo Bills with a dominant performance against the Rams.

Lions vs Cardinals Pick for the 2024 NFL Week 3 Game
Game Day Showdown: Insider Picks You Can’t Afford to Miss for Lions vs. Cardinals!

2024 NFL Season | 104th season of National League in the United States
Week 3: Thursday, September 19th – Monday, September 23rd, 2024

Betting 2024 Detroit Lions at Arizona Cardinals Week 3 Game

Two 1-1 teams are set to clash on Sunday afternoon in an exciting Week 3 matchup in the NFL, as the Detroit Lions travel to face the Arizona Cardinals.

Both teams are eager to move above .500 after a mixed start to the season.

The Lions opened the season strong with a win over the Los Angeles Rams in Week 1 but followed that with a tough loss to the Tampa Bay Buccaneers in Week 2.

Detroit is now sitting a game behind the Minnesota Vikings in the NFC North standings.

Meanwhile, the Arizona Cardinals began their season with a loss to the Buffalo Bills but bounced back impressively by dominating the Rams at home in Week 2.

Arizona is tied with the San Francisco 49ers for second place in the NFC West, trailing the Seattle Seahawks by a game.

NFL TNF Week 3: Detroit Lions at Arizona Cardinals
Sunday, September 22nd, 2024 at 4:25 PM FOX | State Farm Stadium, Glendale, AZ

ATS Odds: Detroit -3
Money line Odds: Lions -153 / Cardinals +124
Over/Under Odds: 51.5

Writer’s Breakdown and Pick for the Lions vs Cardinals Game

Former Ohio State Buckeyes’ Marvin Harrison Jr. Shines Early

The standout performance for Arizona in Week 2 came from rookie wide receiver Marvin Harrison Jr., who caught two touchdown passes in the win over the Rams.

After a quiet debut in Week 1, Harrison showed his potential as a go-to target for quarterback Kyler Murray.

Murray, who has looked sharp through two games, has completed 38 of 52 passes for 428 yards and four touchdowns without throwing an interception.

Arizona’s ground game has been led by James Conner, who has rushed for 172 yards and two touchdowns so far this season.

Conner did lose a fumble in Week 2, but his overall performance has provided balance to the Cardinals’ offense.

Tight end Trey McBride has emerged as Murray’s most reliable short-yardage target, leading the team with 11 receptions for 97 yards.

The Cardinals are set to continue their home stretch after this game, with a Week 4 matchup against Washington.

Following that, they’ll face two tough road games against the San Francisco 49ers and Green Bay Packers.

Lions Offense Looking for a Big Time Rebound

Detroit’s offense, led by quarterback Jared Goff, has had a busy start to the NFL season.

Goff has thrown the ball 83 times through two games, completing 52 passes for 524 yards but has only one touchdown to his name, which went to wide receiver Jameson Williams.

Despite the volume of passing attempts, the Lions have struggled to find the end zone, and Goff will need to improve his efficiency in the red zone if the Lions want to bounce back in Week 3.

In the backfield, the Lions are leaning on a tandem of running backs, David Montgomery and rookie Jahmyr Gibbs.

Montgomery has scored two touchdowns so far, while Gibbs has added one of his own.

Although Williams has been Goff’s primary target in the passing game, wideout Amon-Ra St.

Brown is expected to play a bigger role as the season progresses.

Rookie tight end Sam LaPorta has had a slow start, recording just six catches for 58 yards through two games.

After this road game in Arizona, Detroit returns home to host the Seattle Seahawks in Week 4, followed by a bye week.

The Lions will then face back-to-back road games against the Dallas Cowboys and Minnesota Vikings, both crucial matchups for their playoff hopes, just check out the NFL playoffs odds to confirm it.

Cardinals Going to Grab a Win at Home | Get Your Final Pick Here!

This matchup between the Lions and Cardinals has the potential to be one of the most entertaining games of Week 3.

Both teams have offenses capable of moving the ball quickly and putting points on the board.

While Detroit has the talent to make it a close game, Arizona’s home-field advantage and strong performance in Week 2 suggest they’ll come out on top.

Our pick is to take the Cardinals straight up.

Bet Arizona +124 on the money line to upset Detroit at home on Sunday.

NFL Week 3 SU Pick: Arizona Cardinals Moneyline

Detroit at Arizona Betting Trends Today

Detroit has won 4 of the last 5 games covering in all 4, with 1 tie in the 2019 season.
Arizona allowed 232 and 216 passing yards in their first two games.
Jared Goff has averaged above 260 yards passing per game the past 3 seasons.
Both teams are averaging over 20 points in both scoring and defence.
The Cardinals are underdogs against the Lions in Week 3.
Arizona has a 42.79% chance to beat Detroit.
The Cardinals are +3 vs. the Lions in Week 3.
The Week 3 over/under for Cardinals vs. Lions is set at 52.5.
The Cardinals’ moneyline is +124 in Week 3, while the Lions’ is -148.
Arizona are 4-21 SU in their last 25 games when playing as the underdog.
Arizona are 4-19 SU in their last 23 games at home.
Detroit are 14-3 SU in their last 17 games when playing as the favourite.
Detroit are 9-2 ATS in their last 11 games on the road.

Cardinals vs. Lions Series History

Last meeting:
Lions 30, Cardinals 12 on October 23rd, 2021: Week 15 Match – Ford Field, Detroit, MI

Head-to-head (includes postseason games):
Detroit Lions lead series 35-28-6

Bet the NFL Week 3 | NFL Live Betting MyBookie Betting Lines for the Games

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Wednesday’s injury report for Cardinals-Lions. pic.twitter.com/VZhqdwIrRo
— Josh Weinfuss (@joshweinfuss) September 18, 2024

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What is the Point Spread of an NFL Game? Let’s Find Out

The point spread in an NFL game is a betting tool that helps balance the competition between two teams.

For instance, if the Detroit Lions are favored by 3 points against the Arizona Cardinals, the point spread would look like this:

Lions -3 (they must win by more than 3 points)
Cardinals +3 (they can either win or lose by less than 3 points)

So, if the final score is:

Lions 27, Cardinals 24: A bet on the Lions would lose (they didn’t cover the spread).
Lions 28, Cardinals 24: A bet on the Lions would win (they covered the spread).

Understanding the point spread is essential for making informed NFL bets. For the latest updates, check out our NFL News section!

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Lions vs Cardinals 2019 NFL Week 1 Odds, Analysis & Prediction

Previous Betting News

The Arizona Cardinals will look to get their new era off to a positive start when they host the Detroit Lions in their regular season opener on Sunday, live from State Farm Stadium in Glendale, Arizona. With the Cards in the beginning stages of a massive rebuild and the Lions looking to bounce back from their uninspiring season in their first year under head coach Matt Patricia a year ago, let’s find out which team is offering the best value against their NFL odds in this intriguing matchup.

Lions vs Cardinals 2019 NFL Week 1 Odds, Analysis & Prediction

When: Sunday September 8, 2019, 4:25 PM ET
Where: State Farm Stadium, Glendale, Arizona
TV: FOX
NFL Week 1 Odds: Detroit -2.5 / Total: 47.5

Why Bet On Detroit at -2.5?

The Lions look like a good pick in this contest because they have the better defense and a more experienced quarterback under center in veteran Derek Carr. The bad news is that Detroit is looking to rebound after going a discouraging 6-10 last season and they didn’t look good at all in going 0-4 in the preseason while getting held to 23 points or less in each contest. The Lions finished a discouraging 25th in scoring (20.3 ppg) and mediocre 16th in points allowed (22.5 ppg).

Why Bet On Arizona at -2.5?

The best reasons to back the Cardinals are that Arizona is playing at home and looking to get off to a positive start under first-time head coach Kliff Kingsbury. In addition to that, Arizona now has a gifted signal-caller in quarterback Kyler Murray and will almost certainly have a much better offense than they did a year ago when they finished dead last in scoring (14.1 ppg). The Cards went 1-3 in the preseason, but the good news is that Murray looked pretty ready to handle the rigors and faster speed of the NFL after winning the Heisman at Oklahoma a year ago.

NFL Week 1 Betting Prediction for Lions vs Cardinals

Detroit was solid, but definitely, not great, defensively last season, but I contend that the Lions made the wrong move by hiring head coach Matt Patricia when they would have been better off hiring an offensive-minded head coach to help Matthew Stafford reach his full and as of yet, unfulfilled potential.

For this Week 1 regular season opener, I’m going with Arizona to get the big upset win in a contest that looks like a flat-out shootout just waiting to happen. I know the Lions have gone an impressive 6-2 ATS in their last 8 road games and 11-5 ATS in their last 16 games in Week 1, but the home team in this rivalry has gone a blistering 12-2 in the last 14 meetings while the underdog has gone 5-2 ATS in the last seven meetings. With the Lions going 1-7 ATS in their last eight road dates against Arizona, I’m going with the electrifying Kyler Murray to lead the Cardinals to the outright win and ATS cover as a slight home dog!

Pick: Arizona +2.5