2022 NFL Betting Predictions for Week 1: Analysis & Picks of Every QB Matchups

Next week, the United States’ most popular sports league begins another season when NFL teams hit the gridiron in week 1. In addition to betting against the spread and over or under total scores, NFL handicappers can put money behind individual performances. Check out a list of which quarterbacks in every game outplays his rival so you can get ready to place your bets against their NFL Odds.

NFL Week 1 Quarterback Matchups Predictions for Each Game

2022 NFL Week 1

When: Thursday, September 8 – Monday, September 12

Buffalo – Josh Allen at LAR – Matthew Stafford | Thursday, September 8

Supposedly, Matthew Stafford’s elbow is one-hundred percent. But even if Staff has a fantastic day throwing the football, there’s no way he outplays Josh Allen. Rams stars Jalen Ramsey and Leonard Floyd are questionable. So Allen should have a great game.

Top QB: Josh Allen

New Orleans – Jameis Winston at Atlanta – Marcus Mariota | Sunday, September 11

In 2019, Jameis Winston led the NFL in passing yards. This season, Jameis has enough weapons to make your head spin. Mariota has no shot versus the Saints’ D.

Top QB: Jameis Winston

San Francisco – Trey Lance at Chicago – Justin Fields | Sunday, September 11

Both players have talent. The difference in the game is their supporting casts. Deebo Samuel plays for San Francisco so Lance gets the nod.

Top QB: Trey Lance

Pittsburgh – Mitch Trubisky at Cincinnati – Joe Burrow | Sunday, September 11

Cool Joe should carve up the Pittsburgh defense because Steelers linebacker T.J. Watt is questionable. Even if Watt plays, Burrow exposes Pittsburgh. Trubisky isn’t doing more this season than keeping the QB1 chair warm for Kenny Pickett.

Top QB: Joe Burrow

Philadelphia – Jalen Hurts at Detroit – Jared Goff | Sunday, September 11

Hurts should outplay Goff. Jalen has more weapons. But Goff has experience and this happens in Detroit. The Lions QB has the better game.

Top QB: Jared Goff

New England – Mac Jones at Miami – Tua Tagovailoa | Sunday, September 11

Patriots gunslinger Mac Jones had to learn a new system. Tua Tagovailoa gets to throw to Tyreek Hill, Jaylen Waddle, and Mike Gesicki, one of the best tight-ends in football. Tua outplays Mac.

Top QB: Tua Tagovailoa

Baltimore – Lamar Jackson at NYJ – Zach Wilson | Sunday, September 11

Wilson may not play. If he doesn’t, Joe Flacco will. Flacco never posted brilliant stats. Ever. So Jackson gets the nod.

Top QB: Lamar Jackson.

Jacksonville – Trevor Lawrence at Washington – Carson Wentz | Sunday, September 11

Wentz versus Lawrence should be fun. The real key is what happens on the defensive side. The Jaguars defense will play better because Washington DE Chase Young is out.

Top QB: Trevor Lawrence

Cleveland – Jacoby Brissett at Carolina – Baker Mayfield | Sunday, September 11

Brissett is a backup. Baker isn’t. Also, Mayfield will have revenge on his mind.

Top QB: Baker Mayfield.

Indianapolis – Matt Ryan at Houston – Davis Mills | Sunday, September 11

Ryan has too many weapons for Davis Mills to outplay him. Mills will do what he can and he’s a good quarterback, a legit QB1, but if Ryan has a great season, a hall of fame bust could be in his future.

Top QB: Matt Ryan

NYG – Daniel Jones at Tennessee – Ryan Tannehill | Sunday, September 11

Tannehill has more experience and is a good quarterback. Ryan could have an excellent game. But we should take a chance on Jones. Brian Daboll, NYG’s new head coach, is one of the most creative offensive coordinators in the league. Daniel can post terrific stats in both the passing and rushing games.

Top QB: Daniel Jones

Green Bay – Aaron Rodgers at Minnesota – Kirk Cousins | Sunday, September 11

Rodgers always has big games versus the rival Vikings. However, wideout Justin Jefferson catches passes from Kirk Cousins. So Kirk should have the better stats.

Top QB: Kirk Cousins

Kansas City – Patrick Mahomes at Arizona – Kyler Murray | Sunday, September 11

Murray’s favorite target, DeAndre Hopkins, must miss the first six games of the season. Mahomes will light up an okay but not great AZ defense.

Top QB: Patrick Mahomes

Tampa Bay – Tom Brady at Dallas – Dak Prescott | Sunday, September 11

If you’re a Brady fan, you’ve got to worry for your dude. Brady not only faces Dallas’ fearsome defense, but he plays behind an offensive line with three new faces. Dak can dominate a Tampa D that ranked twenty-first versus the pass last season.

Top QB: Dak Prescott

Denver – Russell Wilson at Seattle – Geno Smith | Monday, Sep. 12

In his first game as a Denver Bronco, Wilson returns to the Emerald City. Geno Smith gets the start but he may not play the whole game. So it’s impossible to know how well Smith will perform. We know Denver didn’t trade for Russell so he could hand the ball off to Javonte Williams and Melvin Gordon III all day.

Top QB: Russell Wilson

I have read enough, I need to place my bet now. What to do?