Now that Week 5 of the NFL season is behind us; it’s time to take a look at the Week 6 matchups. Let’s take a look at the quarterback matchups in each game, and we’ll give you our NFL Betting predictions for each game as well.
Week Six Quarterback Matchups | NFL Betting Predictions
Washington Commanders @ Chicago Bears (-1)
This could be another Thursday night clunker. Ron Rivera has blamed Carson Wentz for the poor play of the Washington offense. The Bears offensive coaching staff won’t seem to turn Justin Fields loose. Something’s gotta give here. We like the Bears to win a low-scoring affair at home and cover the spread.
San Francisco 49ers (-5.5) @ Atlanta Falcons
Jimmy Garoppolo is going to need to play well, as the Niners defense was hit hard by injuries in their win over Carolina. Marcus Mariota has been average at best, and if the Falcons continue to lose, we could see Desmond Ridder at some point. The Niners win, but won’t cover.
New England Patriots @ Cleveland Browns (-3)
Bailey Zappe has looked decent after taking over for the injured Mac Jones and Brian Hoyer. Jacoby Brissett has been serviceable for the Browns. Cleveland gets the win in this one, covering the spread.
New York Jets @ Green Bay Packers (-7)
Zach Wilson has looked good since coming back from injury. The Jets are relying heavily on the running game. Aaron Rodgers will be mad after losing to the Giants last week. The Jets are playing over their heads, and they’ll come back down. Green Bay wins by 10.
Jacksonville Jaguars @ Indianapolis Colts (-2)
Trevor Lawrence was getting rave reviews until last weekend’s clunker. Matt Ryan hasn’t looked good in Indy blue as of yet. The Colts are eventually going to start playing well. Jonathan Taylor could be back next week. The Colts win by a touchdown.
Minnesota Vikings (-3) @ Miami Dolphins
After the Jets took it to the Dolphins, the Vikings are the road favorites. Kirk Cousins has done some nice things this season. We’re not sure who’ll be under center for the Dolphins. It could be any of the three quarterbacks, depending on the concussion protocol. Until we know who’s under center, it’s hard to make a prediction. However, we like Miami right now.
Cincinnati Bengals (-1.5) @ New Orleans Saints
The Cincinnati offensive line isn’t as nearly improved as many thought they’d be. Joe Burrow hasn’t lived up to expectations. We’re not sure whether we’ll see Andy Dalton or Jameis Winston under center for the Saints. This could be a breakout game for Cincinnati. Take the Bengals and the cover.
Baltimore Ravens (-5) @ New York Giants
Daniel Jones has been hobbled by a bum ankle, but the running game has led the Giants to a 4-1 record. Lamar Jackson is one of the most dynamic players in the game. The Giants are riding high, but they’ll come back down next week. Baltimore leaves Jersey with a big win and a cover.
Tampa Bay Buccaneers (-8) @ Pittsburgh Steelers
At some point, Tom Brady and the Buccaneers are going to have to wake up, right? Well, the Steelers have been the team to play when your offense is struggling. The Tampa Bay defense should have its way with Steelers rookie Kenny Pickett. While Tampa wins, we’re not confident in them covering.
Carolina Panthers @ Los Angeles Rams (-11)
Baker Mayfield is out. Matt Rhule is out. PJ Walker is in. Steve Wilks is in. The Panthers are a mess, and will the coaching change fix things? Only time will tell. The Rams offensive line is also a mess. The Rams can’t run the ball. Matthew Stafford just hasn’t gotten going, but the Panthers could be just what he needs. The Rams win by 10 and don’t cover.
Arizona Cardinals (-3) @ Seattle Seahawks
Geno Smith has been one of the biggest surprises in the league, as the Seahawks haven’t missed Russell Wilson at all. Kyler Murray has been one of the league’s biggest disappointments. Seattle is better than people give them credit for. They beat the Cardinals on Sunday.
Buffalo Bills (-1) @ Kansas City Chiefs
Patrick Mahomes vs. Josh Allen. What a game this will be. The Bills haven’t been able to beat the Chiefs, until now. Buffalo wins on a late field goal.
Dallas Cowboys @ Philadelphia Eagles (-5)
Could we see the return of Dak Prescott, or will Cooper Rush continue to lead the Cowboys. The Eagles are the league’s only undefeated team. Jalen Hurts has done a great job thus far. Philly shows that they’re the class of the NFC East. They beat Dallas by a touchdown.
Denver Broncos @ Los Angeles Chargers (-5.5)
We don’t know the status of Russell Wilson yet. Justin Herbert has had injury problems in his receiving corps. Austin Ekeler has kicked it into gear over the last couple of weeks. The Denver defense is good, and will keep this close. The Chargers win, but won’t cover.
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Best 2022 NFL Week 6 Games to Bet On, Early Analysis, and Picks
The most important matchup in NFL Week 6 this season projects as Buffalo versus Kansas City. Josh Allen and the Bills must travel to Patrick Mahomes and the Chiefs. Other top week 6 games include New England at Cleveland, and the Saints hosting the Bengals. A couple of important division games, Dallas at Philadelphia and Chargers at Broncos, also happen in week 6. Check out analysis and early NFL Betting picks for seven terrific contests in NFL Week 6.
Must Bet Games in Week 6 of the 2022-23 NFL Season
2022 NFL Week 6
- When: Thursday, Oct. 13 – Monday, Oct. 17
New England Patriots at Cleveland Browns | Sunday, Oct. 16
Deshaun Watson might still be on the bench waiting out an 8-game suspension. If that’s case, Mac Jones and New England should do enough for the road win.
Even if Watson plays, the Patriots could be difficult to beat. If Deshaun does put on the cleats, the Patriots may offer overlay odds against the spread.
NFL Week 6 Pick: New England Patriots
Jacksonville Jaguars at Indianapolis Colts | Sunday, Oct. 16
Jacksonville should be a much better team than people believe. By week 6, we’ll know for sure. If you believe the Jaguars are a decent team, they won’t get as many points versus Matt Ryan and the Colts than we might think. Still, Jacksonville can cover whatever the spread, even if they’re a 1 or 2 point favorite. The Jags have a good defense and Trevor Lawrence will be a much better quarterback in 2022.
NFL Week 6 Pick: Jacksonville Jaguars
Minnesota Vikings at Miami Dolphins | Sunday, Oct. 16
Week 6 is early, but it’s not too early for teams like the Vikings and Dolphins to play for a wildcard spot. Both teams will struggle to win their respective division, Minnesota is in the NFC North and Miami is in the AFC East, but both can make the playoffs via a wildcard.
In this game, the Dolphins have the edge. Unless Tua Tagovailoa doesn’t take the next step, the Fins should play well enough to win and cover.
NFL Week 6 Pick: Miami Dolphins
Cincinnati Bengals at New Orleans Saints | Sunday, Oct. 16
Barring injuries, Bengals versus Saints will be a great game. New Orleans is tough to beat at home and the Saints will have one of the best defenses in the NFL.
Cincinnati improved their offensive line and has a good defense. Because the Saints play in the Superdome, they get the nod against the spread.
NFL Week 6 Pick: New Orleans Saints
Buffalo Bills at Kansas City Chiefs | Sunday, Oct. 16
If Kansas City and Buffalo have both dominated in their first 5 games, this could be a battle for the best record in the league. KC has a big edge because this happens at Arrowhead Stadium, but Buffalo should be the slightly better team.
In last season’s KC versus Buffalo game, the Bills’ Josh Allen dominated. Kansas City’s defense is going to have a tough time containing Allen. Bills win and cover.
NFL Week 6 Pick: Buffalo Bills
Dallas Cowboys at Philadelphia Eagles | Sunday, Oct. 16
Dallas coach Mike McCarthy feels the Cowboys can win the Super Bowl. The roster is deep with talent, Dak Prescott and CeeDee Lamb will be a force, and the defense should be one of the best units in the NFL.
The Eagles feel they’re the class of the NFC East. This game could go a long way in determining which team wins the division. In this head-to-head, the Boys are the play. Dallas has a huge edge at quarterback.
NFL Week 6 Pick: Dallas Cowboys
Los Angeles Chargers at Denver Broncos | Monday, Oct. 17
Chargers versus Broncos is a division game that could determine which AFC West team is in the best position for either a division title or a wildcard spot.
This game should come down to which quarterback can beat the opposing defense. Russell Wilson is good enough to beat the Bolts’ D. But the Chargers’ defense should be better than Denver’s this season.
Justin Herbert could torch the Broncos’ D. LAC has a real shot to grab an SU win. The Chargers should definitely cover.
NFL Week 6 Pick: Los Angeles Chargers
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