2023 NFL Week 5 ATS Picks

The National Football League is moving along to Week 5 of the season. Let’s take a look at some of our favorite Against the Spread Picks for the week.

Let’s take a look at the NFL Week 5 Against the Spread Picks.

NFL Week 5 ATS Picks | MyBookie Regular Season Preview

2023-24 NFL | 104th season of the National Football League
NFL Week 5: Thursday, October 4th – Monday, October 10th, 2023

Buffalo Bills over Jacksonville Jaguars

ATS: Bills -5.5
Sunday, October 8th, 2023 at 9:30 AM | NFL NET
Tottenham Hotspur Stadium, London

The London game is early on Sunday. Josh Allen and the Buffalo Bills are on the right track. After losing their opener, they have been running through opponents. Now they get a Jacksonville team that spent the week in London. That may not matter.

The Bills have revenge on their mind from the Jaguars beating them in a low-scoring affair a season ago. Look for Buffalo to continue playing great football with a win by a touchdown or more in this one over the Jaguars.

NFL Week 5 ATS Pick: Bills -5.5 | Bet Bills over Jaguars
MyBookie Betting Lines for the Game

Detroit Lions over Carolina Panthers

ATS: Lions -9
Sunday, October 8th, 2023 at 1:00 PM | FOX
Ford Field, Detroit, MI

The Carolina Panthers are winless through their first four games. That does not change anytime soon. The Lions are an impressive offensive team with an excellent defense. Bryce Young will have a tough time moving the football against the Lions. Detroit at home means a better and more solid game from Jared Goff.

Look for the Lions to drive the football via the pass and also on the ground and continually grow the lead all night. The Lions win this game by 10+ points on Sunday.

NFL Week 5 ATS Pick: Lions -9 | Bet Lions over Panthers
MyBookie Betting Lines for the Game

Philadelphia Eagles over Los Angeles Rams

ATS: Eagles -4.5
Sunday, October 8th, 2023 at 4:05 PM | FOX
SoFi Stadium, Inglewood, CA

The Eagles and 49ers seem to be on a collision course again to meet in the NFC title game. While this is just Week Five, and there is a ton of football left to be played, the Eagles look good once again.

Philadelphia needed overtime, but it was evident who the better team was on Sunday. Jalen Hurts, the run game continues to gash defenses, and AJ Brown is emerging as a Top 5 receiver in the league.

Look for the Philadelphia defense to put a ton of pressure on Matthew Stafford and his young core of receivers.

NFL Week 5 ATS Pick: Eagles -4.5 | Bet Eagles over Rams
MyBookie Betting Lines for the Game

Denver Broncos over New York Jets

ATS: Broncos -2.5
Sunday, October 8th, 2023 at 8:15 PM | ABC, ESPN
Levi’s Stadium, Santa Clara, CA

We cannot call this a great game. But we can call this a competitive and exciting game. This is a game between a pair of one-win teams. But, better yet, it’s Sean Payton against Nathaniel Hackett: Payton, the new Broncos coach, against Hackett, the coach from last season. Payton has been on record for bashing the job Hackett did a season ago.

Denver is coming off a win over the Bears, while the Jets lost on Sunday Night to the Kansas City Chiefs. Denver has been horrific on defense, but the Jets have been pretty poor on offense. The Jets present a good defense. This will be interesting, but we will take the Broncos to win their second straight!

NFL Week 5 ATS Pick: Broncos -2.5 | Bet Broncos over Jets
MyBookie Betting Lines for the Game

San Francisco 49ers over Dallas Cowboys | Sunday Night Football

SNF ATS: 49ers -3.5
Sunday, October 8th, 2023 at 8:20 PM | NBC
Lambea

This could be the game of the year so far, and it’s just Week 5. The San Francisco 49ers and their high-powered offense will take on the Dallas Cowboys and their imposing defense.

Can the Cowboys slow Christian McCaffrey and his ability to gash through any defense he plays? Will the Cowboys have an answer for Brock Purdy? Can the 49ers avoid throwing the ball away and giving the Dallas defense some ammo for a big play?

These two teams have Super Bowl aspirations, and this is a potential playoff matchup. Look for a fun one on Sunday Night Football.

NFL Week 5 SNF ATS Pick: 49ers -3.5 | Bet 49ers over Cowboys
MyBookie Betting Lines for the Game

The following NFL betting odds are based on MyBookie Sportsbook.

There it is. Those are our NFL Week 5 Against the Spread Picks. They are five favorites, but those are our favorite five games for the week. Enjoy the week of games, and best of luck with all your NFL Betting!

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