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The 2022 MLB has resumed after the All-Star Break, and the action is really going to start heating up over the next few weeks. Playoff races in both leagues have really started to heat up, and there will be some terrific betting opportunities ahead.

Teams have been able to reset their pitching rotations after the break, and that is another factor in MLB Betting. With that in mind, here are four of the best-winning MLB SU picks for the weekend.

Winning SU Picks for the Weekend Action | MLB Week 16 Betting Predictions

St. Louis Cardinals at Cincinnati Reds (Friday)

The St. Louis Cardinals enters the second half in second place in the NL Central, but only by a half-game. St. Louis begins the second half in Cincinnati against the Reds, and this team needs to rack up the wins.

Veteran Adam Wainwright makes the start for St. Louis on Friday night, and the veteran has continued to pitch well for the Cardinals. St. Louis also has a loaded lineup led by Paul Goldschmidt and Nolan Arenado.

St. Louis is going to win this game, and they are the top betting pick.

Philadelphia Phillies vs Chicago Cubs (Saturday)

The Chicago Cubs will be in Philadelphia to begin the second half of the year, and it’s been a long season for the visitors. Chicago is likely going to be an underdog every game this weekend, but their toughest test will take place on Saturday.

Zack Wheeler starts on Saturday for the Phillies, and he is 8-5 with a 2.89 ERA on the year. The Phillies have a team with a ton of power, and that lineup should do some damage in every game in this series.

It’s hard to guarantee a win in MLB action, but the Phillies are winning on Saturday.

New York Yankees at Baltimore Orioles (Saturday)

The AL East continues to be the best division, and baseball and even the Baltimore Orioles have gotten into the mix. Baltimore will look to continue to surprise this weekend when they play host to the New York Yankees.

Gerrit Cole is set to make the start for the Yankees on Saturday, and he is 9-2 with a 3.02 ERA this season. New York also has a loaded offensive lineup that is led by Aaron Judge and Giancarlo Stanton.

As good as Baltimore has been this season, they don’t have an offense to beat the Yankees. Take New York to win the game on Saturday in this series.

Miami Marlins at Pittsburgh Pirates (Sunday)

Sandy Alcantara was an All-Star pitcher for the National League, and he will be back on the mound on Sunday. Alcantara has been terrific this season, and it’s always a good idea to back the Marlins when he is on the mound.

Pittsburgh will be hosting the Marlins this weekend, and the Pirates have been better than expected. Don’t be surprised to see the Pirates win a game in Pittsburgh, but it won’t happen on Sunday.

Take the Miami Marlins on Sunday behind a dominant outing from Alcantara as he carves up the Pirates.