NFL Game Odds Week 10 Betting Odds

This season, NFL 10 shows plenty of important contests, including Broncos at Titans, Jaguars at Chiefs, and the Packers hosting the Cowboys. Check out analysis and early NFL Betting picks for those three matchups as well as three other games we predict will be must bets in NFL Week 10.

Must Bet Games in Week 10 of the 2022-23 NFL Season

2022 NFL Week 10

When: Thursday, Nov. 10 – Monday, Nov. 14

Denver Broncos at Tennessee Titans | Sunday, Nov. 13

Both the AFC West and the AFC South will be competitive divisions in 2022. Russell Wilson will be focused to lead the Broncos to the postseason.

When Wilson’s mind is on football, he’s as good as any quarterback in the NFL. The Titans could be in desperation mode by week 10. Both the Jaguars and Colts will be much better this season than they were in 2021.

Denver will have a big shot at winning this straight up. Ryan Tannehill and Derrick Henry will struggle versus the Broncos’ defense.

NFL Week 10 Pick: Denver Broncos

Jacksonville Jaguars at Kansas City Chiefs | Sunday, Nov. 13

Kansas City is one of the best teams in the National Football League. But although Patrick Mahomes and his mates are great, it doesn’t mean KC won’t be in a must win situation come NFL Week 10.

The Chiefs play in the loaded AFC West. The out of division schedule is brutal. So Mahomes and his buddies may have to step it up versus Trevor Lawrence and the upstart Jacksonville Jaguars.

Kansas City won’t mess around in this game. Expect a big win and cover.

NFL Week 10 Pick: Kansas City Chiefs

New Orleans Saints at Pittsburgh Steelers | Sunday, Nov. 13

So far, Kenny Pickett has played great football. Mike Tomlin gave the impression Pickett would sit on the bench this season. But that was before Kenny completed 17-of-22 for 171 yards and threw 3 touchdowns in 2 preseason games.

No matter who starts in this one, the Saints defensive line will rock the Steelers’ quarterback. New Orleans’ defense should be one of the best in the league this season. Also, the Saints could be fighting for a playoff spot in this. New Orleans wins and covers.

NFL Week 10 Pick: New Orleans Saints

Dallas Cowboys at Green Bay Packers | Sunday, Nov. 13

The Cowboys and Packers are good enough to win the Super Bowl. This matchup in week 10 could determine which team has the inside track for homefield during the NFC Playoffs.

Dallas will boast one of the NFL’s best offenses and one of the league’s best defenses. But this happens at Lambeau where it’s close to impossible to beat Aaron Rodgers and the Pack. Green Bay grabs the cover victory.

NFL Week 10 Pick: Green Bay Packers

Arizona Cardinals at Los Angeles Rams | Sunday, Nov. 13

Neither the Cardinals nor the Rams are the same team from last season. The defending Super Bowl Champions must hope Matthew Stafford’s elbow isn’t an issue in 2022.

Kyler Murray and the Cards must hope the defense picks it up. This game should be a battle between a couple of desperate teams. The Rams have the edge because this at SoFi. LAR wins and covers.

NFL Week 10 Pick: Los Angeles Rams

Los Angeles Chargers at San Francisco 49ers | Sunday, Nov. 13

If Chargers quarterback Justin Herbert and San Francisco QB Trey Lance play as well this season as so many expect, Bolts versus Niners in week 10 could be a Super Bowl 57 preview.

Both teams bring stacked defenses to the field. The Chargers’ offense projects as slightly better but because this happens at Levi’s Stadium in Santa Clara, the 49ers figure to win. San Francisco should also produce a cover victory.

NFL Week 10 Pick: San Francisco 49ers

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