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Given what is going on in the world of sports right now, it is a tough time to be betting on games. Besides the things you usually look for when wagering on a specific matchup, you now also need to be paying attention to which players are entering health and safety protocols. The hope was that we would get through this season without any issues, but we are currently seeing a lot of players miss games due to COVID. This is something you definitely need to keep in mind before making any plays, so be sure to do that before playing any picks. Let’s now jump into our parlay picks for NFL Week 16 so you can make your bets against the NFL odds.

2021 NFL Season Week 16 Parlay Picks to Bet On

NFL SU Parlay – Titans, Colts, Bengals

Tennessee is not in the best run of form at the moment, heading into their Thursday tilt with the surging San Francisco 49ers having lost 3 of their last 4. They are too good to be struggling this long, so look for them to break out and get the win.

Getting hot in the final weeks of the season is always good, and that is where the Indianapolis Colts are right now. They have a tough one against the slumping Arizona Cardinals on Saturday, but I think their momentum spills over into Week 16.

There is a fantastic battle going on in the AFC North right now, but the picture will become a little clearer this weekend when the Bengals host the Baltimore Ravens. I expect a tight battle in this one, but I like Cincinnati at home.

NFL ATS Parlay – Chargers (-9 ½), Seahawks (-6 ½), Cowboys (-10 ½)

We are at the stage of the season where teams are now beginning to scramble for playoff positions. The Chargers are in right now and can help their cause further with a win over Houston this weekend. I think they win that one going away.

This is a bit of a risk, especially when you consider that both the Bears and the Seahawks basically have nothing left to play for at this point. I don’t expect a ton of offense here, but I do like Seattle to win and cover the spread.

The Dallas Cowboys are getting hot again in the late stages of the season and will be looking to keep their foot on the gas when they face Washington in Week 16. I like the Cowboys to run away with the win as they continue to push for the #1 seed in the NFC.

NFL O/U Parlay – Browns (O44), Bills (O43 ½), Lions (O42 ½)

With a 7-7 record, there is no margin for error for the Browns, but they look to be in trouble with a trip to Green Bay ahead of them in Week 16. The Packers have seen 4 of their last 5 games go OVER the point total and I expect more of the same here.

There are a lot of big games on the Week 16 schedule, but few as important as the Bills and the Patriots matchup. The Bills are on a run that has seen 11 of their last 16 road games go OVER, while the OVER also seems to hit when the Patriots play at home.

My feelings on this game may change based on the playing status of Jared Goff come this weekend. Still, when the Lions and Falcons hook up in Atlanta, it tends to deliver some offense, with 7 of their last 9 meetings going OVER.

I have read enough, I need to place my bet now. What to do?