NFL Week 12 QB Matchups Betting Preview, Odds & Picks for Every Game

We’ve made it to Week 12. It’s now time to take a look at the quarterback matchup for each game, and we’ll give you our early NFL Betting predictions.

Who’ll Win the Quarterback Matchups in Week 12? | NFL Lines & Betting Predictions

Buffalo Bills @ Detroit Lions (+10) 

Buffalo will return to Detroit for their second straight game at Ford Field. Josh Allen played well there on Sunday. Jared Goff has the Lions on a three-game winning streak.

Unfortunately for the Lions, the streak will end on Thursday. Buffalo wins but won’t cover.

New York Giants @ Dallas Cowboys (-8)

After seeing what Dak Prescott and the Dallas Cowboys did to the Minnesota Vikings, the Giants should be scared. New York is a good team, and Daniel Jones has done well in Brian Daboll’s system.

Dallas will shut down Saquon Barkley and will win this one easily while covering the spread.

New England Patriots @ Minnesota Vikings (-3)

It’s a prime-time game, and Kirk Cousins tends to struggle in prime time. We don’t think that will be the case on Thanksgiving night.

Mac Jones has struggled, and we could see Bailey Zappe. The Vikings rebound after the drubbing they took from Dallas. The Vikings win and cover.

Houston Texans @ Miami Dolphins (-12)

Tua Tagovailoa has the Miami offense firing on all cylinders. While the Miami defense is still a work in progress, we don’t think Davis Mills will get much done against it. Go with Miami to cover.

Cincinnati Bengals @ Tennessee Titans (+1.5)

Joe Burrow should have his favorite weapon back, as Ja’Marr Chase is scheduled to return. We don’t know if Joe Mixon will be ready, though.

Ryan Tannehill will hand the ball off to Derrick Henry a lot in this one. Cincinnati beats Tennessee by a field goal.

Baltimore Ravens @ Jacksonville Jaguars (+4.5)

Trevor Lawrence is capable of having a great game at any time. Lamar Jackson hasn’t been running as much as of late, but that could all change. Baltimore wins the game but doesn’t cover.

Atlanta Falcons @ Washington Commanders (-3)

Taylor Heinicke has brought winning back to Washington. Marcus Mariota will be without one of his top targets for the rest of the season as Kyle Pitts will require knee surgery. Washington wins by double digits.

Tampa Bay Buccaneers @ Cleveland Browns (+3)

It’s time for the Tom Brady resurgence. The days are numbered for Jacoby Brissett. Tampa Bay by a touchdown.

Denver Broncos @ Carolina Panthers (+2.5)

I don’t know how we can trust Russell Wilson, even against a poor Panthers team. That means we’re going to trust Baker Mayfield. Panthers win.

Chicago Bears @ New York Jets (-4)

We’re not sure if Justin Fields will play on Sunday. We’re also not sure how much longer Zach Wilson will be starting for the Jets. The Jets win by a touchdown.

Las Vegas Raiders @ Seattle Seahawks (-3.5)

We may be seeing the last few games of Derek Carr in a Raiders uniform. Geno Smith has been one of the biggest surprises in the league this season.

Seattle didn’t look good the last time out, and that was because the Bucs stifled Kenneth Walker III. If he plays well, look out. Seattle wins but doesn’t cover. 

Los Angeles Chargers @ Arizona Cardinals (+3)

Will Kyler Murray return for this one? After Arizona was drubbed by the Niners, we’re not sure if they’ll rebound well from that one. Justin Herbert played well in a heartbreaking loss to the Chiefs. We like the Chargers to win and cover.

Los Angeles Rams @ Kansas City Chiefs (-14)

Patrick Mahomes and the Chiefs just keep on winning, even when he loses some of his weapons. The season can’t get over soon enough for Matthew Stafford and the Rams. KC wins, but won’t cover.

New Orleans Saints @ San Francisco 49ers (-8)

While Andy Dalton has played well for the Saints, he won’t play well enough to beat the surging Niners. Jimmy Garoppolo threw four touchdown passes in a Monday night romp over the Cardinals. Look for Garoppolo and the Niners to keep on rolling. Niners by two touchdowns.

Green Bay Packers @ Philadelphia Eagles (-6.5)

Is this the end of the road for Aaron Rodgers? Without Dallas Goedert, Jalen Hurts loses one of his biggest weapons. Philadelphia wins, but won’t cover.

Pittsburgh Steelers @ Indianapolis Colts (-2.5)

Kenny Pickett has endured a lot of growing pains as a rookie. Jeff Saturday has brought some life to the Colts.

Inserting Matt Ryan back into the lineup may have helped. Indy wins this Monday night clunker by a field goal.

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