NFL Week 15 Odds, QB Matchups Betting Picks for Every Game

It’s time to take a look at the Week 15 NFL matchups. We’ll preview the quarterback play and give you our early NFL Betting predictions for each contest.

Who’ll Win the Quarterback Matchups in Week 15? | NFL Lines & Betting Predictions

San Francisco 49ers (-3.5) @ Seattle Seahawks

Brock Purdy has been great since taking over for the injured Jimmy Garoppolo. Geno Smith continues to play well, but the Seattle defense is letting him down.

The Niners don’t have the best track record in Seattle, but we think they will win this one. This will be a tight game, and the Niners won’t cover, but they leave with a victory.

Indianapolis Colts @ Minnesota Vikings (-5.5)

The honeymoon period for Jeff Saturday has ended. Matt Ryan looks old, and the Colts are ready to move on to next season. Kirk Cousins has been playing well, but much of that goes to Justin Jefferson. Minnesota wins by a touchdown and covers.

Baltimore Ravens (-2.5) @ Cleveland Browns

We have no clue who’ll be under center for the Browns. Could Lamar Jackson return? Will Tyler Huntley be out of the concussion protocol, or will we see Anthony Brown again? Deshaun Watson hasn’t looked like a $230 million player since he returned. We think Cleveland will win this one.

Miami Dolphins @ Buffalo Bills (-7.5)

The Bills will be looking for revenge from their early season loss in Miami. Tua Tagovailoa hasn’t been very good in his last two games, and both were Dolphins‘ losses. Josh Allen must avoid making costly mistakes. Buffalo wins at home by 10.

Atlanta Falcons @ New Orleans Saints (-3)

Desmond Ridder gets the starting nod for this one. The rookie signal caller will be making his first career start. Andy Dalton and the Saints can’t wait for the season to end. Ridder will struggle against the Saints’ defense. New Orleans wins by six.

Pittsburgh Steelers @ Carolina Panthers (-2)

With the status of Pittsburgh starting quarterback Kenny Pickett unknown, we could see Mitch Trubisky again. Carolina has been playing well since Sam Darnold took over. Pittsburgh has also been finding ways to win, and they’ll do so again in this one. Steelers by a field goal.

Philadelphia Eagles (-9) @ Chicago Bears

Jalen Hurts continues to flourish behind the Eagles‘ dominant offensive line. Even though Justin Fields and the Bears are scoring points, they won’t be scoring many this week. The Eagles win this one going away, covering the spread in the process.

Kansas City Chiefs (-14) @ Houston Texans

Kyle Allen and the Texans gave the Cowboys all they wanted last Sunday. We just don’t think that they can do that two weeks in a row. Patrick Mahomes and company will put up a lot of points. Kansas City wins by 17.

Dallas Cowboys (-5) @ Jacksonville Jaguars

Don’t look now, but Trevor Lawrence has the Jaguars‘ offense rolling. They’ll face a tough Dallas defense that barely escaped the Texans last week. We’ll see if Dak Prescott can play better than he did last week. Dallas may win a close one, but they won’t cover. Take the Jags.

Detroit Lions @ New York Jets (Pick Em)

After Mike White was battered and bruised last week, we’re not sure if we’ll see him, Joe Flacco, or the return of Zach Wilson. Jared Goff and the Lions are playing great football and are making a run at a playoff spot. The Lions‘ offense will meet a very good Jets defense. We think the Lions will keep rolling and win the game.

Arizona Cardinals @ Denver Broncos (-1)

The Broncos finally scored some points last week! However, Russell Wilson had a concussion, and Brett Rypien took over. We’re not sure who we will see in this one. Kyler Murray has had his ups and downs this season. We like Denver to win at home in a sloppy game.

New England Patriots @ Las Vegas Raiders (-2)

Neither Mac Jones nor Derek Carr has played well this season. They’ve both shown flashes at times, but both have been very inconsistent. We like Belichick and company in this one.

Tennessee Titans @ Los Angeles Chargers (-3)

Despite Derrick Henry running well, Ryan Tannehill hasn’t been able to muster up much offense. Justin Herbert and his receivers are starting to make things happen and are scoring some points. Los Angeles wins and covers.

Cincinnati Bengals (-3.5) @ Tampa Bay Buccaneers

We may be seeing the end of Tom Brady’s career, and the Buccaneers are holding on to their division lead for dear life. Joe Burrow and the Bengals have things rolling, and they’re looking to make another Super Bowl run. The Bengals win by 10.

New York Giants @ Washington Commanders (-4.5)

Things seem to be slipping for Daniel Jones and the Giants. The Commanders have one of the best defenses in the league, and they always seem to play better when Taylor Heinicke is in command of the offense. These two tied in their last game, but that won’t happen again. Washington by a touchdown.

Los Angeles Rams @ Green Bay Packers (-7.5)

Will we see more Baker Mayfield magic, or will Aaron Rodgers show up big for the Monday night prime-time showdown? We like Rodgers and the Packers to win and cover.