NFL Week 16 QB Matchups Betting Preview, Odds & Picks for Every Game

After a wild Week 15, it’s time to look ahead to Week 16’s slate of games. We’ll now take a look at the quarterback matchups for each game, and we’ll also give you our NFL Betting predictions for each game as well.

Who’ll Win the Quarterback Matchups in Week 16? | NFL Lines & Betting Predictions

Jacksonville Jaguars @ New York Jets (Pick Em)

Trevor Lawrence and the Jags upset the Cowboys last week and are playing well. We’re not sure if Mike White will be cleared to play, or if Zach Wilson will earn another start. We like the Jaguars to win this one.

Atlanta Falcons @ Baltimore Ravens (-6.5)

Desmond Ridder will be under center again for the Falcons. Tyler Huntley should get the start for the Ravens, as Lamar Jackson more than likely won’t be ready to return. While Baltimore may win this one, they won’t cover the spread.

Detroit Lions (-2.5) @ Carolina Panthers

Jared Goff and the Lions have won six out of their last seven, and are now in the thick of the race for the final playoff spot in the NFC. Sam Darnold and the Panthers have played better, but are looking forward to next season. The Lions keep on rolling, as they win and cover.

Buffalo Bills (-9) @ Chicago Bears

Josh Allen and the Bills keep on winning, but every game seems to be close. Justin Fields could break the record for single-season rushing yards by a quarterback in a season. The Bears won’t beat the Bills, but they’ll keep it close. Buffalo wins, but doesn’t cover the spread.

New Orleans Saints @ Cleveland Browns (-3)

Deshaun Watson won his first game since returning, and the Browns defense is playing well. The Saints and Andy Dalton defeated the Falcons. Cleveland wins at home by a touchdown.

Seattle Seahawks @ Kansas City Chiefs (-10)

Patrick Mahomes and the Chiefs need this one to stay in the hunt for the top spot in the AFC Playoffs. Geno Smith and the Seahawks need this one to stay in the NFC playoff race. The Seahawks are 0-5 against the spread in their last five games. Make in 0-6 in their last six after this one.

New York Giants @ Minnesota Vikings (-3.5)

The Vikings had the largest comeback over the Indianapolis Colts last weekend. Kirk Cousins and Justin Jefferson continue to shine. Daniel Jones led the Giants over the Commanders to stay in the playoff race. Minnesota wins the game, but doesn’t cover.

Cincinnati Bengals (-3.5) @ New England Patriots

Joe Burrow led the Bengals to a huge comeback win over the Tampa Bay Buccaneers. Mac Jones did enough to lead the Patriots to a victory, but a huge mistake on the last play of the game cost New England the game. Cincinnati continues to roll and will beat New England by a touchdown.

Houston Texans @ Tennessee Titans (-7) 

Ryan Tannehill and the Titans have hit a rough patch. Kyle Allen and the Texans have played Dallas and Kansas City close, but can’t get over the hump. Houston will play Tennessee tough this week. The Texans won’t win, but they won’t allow the Titans to cover.

Washington Commanders @ San Francisco 49ers (-7)

Is the Taylor Heinicke magic running out? If so, could we see the return of Carson Wentz? Brock Purdy has the Niners rolling, and they’ll continue to roll against the Commanders. The Niners win and cover.

Philadelphia Eagles @ Dallas Cowboys (-1)

The status of Jalen Hurts for this one is unknown at this time. Dak Prescott has the Cowboys ready to make a Super Bowl run. Dallas beats Philadelphia and covers.

Las Vegas Raiders @ Pittsburgh Steelers (-2.5)

Derek Carr and the Raiders got lucky last week. Mitch Trubisky led the Steelers to a win over the Panthers last week. Pittsburgh wins this one by a field goal.

Green Bay Packers @ Miami Dolphins (-4.5)

Tua Tagovailoa and the Dolphins need this game in the worst way, as they are in danger of missing the playoffs. Aaron Rodgers and the Packers are just playing the season out. Miami wins by 10.

Denver Broncos @ Los Angeles Rams (-1)

We’re not sure if we’ll see Russell Wilson under center for Denver. Baker Mayfield has looked good since coming to Los Angeles. We think Denver wins this one.

Tampa Bay Buccaneers (-4) @ Arizona Cardinals

Tom Brady and the Bucs need this one. Colt McCoy will be leading the Cardinals the rest of the way. Tampa comes to Arizona and wins by a touchdown.

Los Angeles Chargers (-2.5) @ Indianapolis Colts

Justin Herbert has the Chargers in the playoffs as of now. Matt Ryan suffered another collapse against Minnesota last week. The Colts just don’t have enough to stop the Chargers. Los Angeles wins and covers in the process.

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