MLB Opening Day Predictions 2025: Stay Updated with the Latest MLB Betting News and Insights

As we prepare to turn the calendar to February, we are starting to hear baseball fans ask. “When is opening day for MLB?”

Before we get to the details of MLB opening day 2025, we have to start by talking about spring training, as we are going to have a ton of games coming our way before we get to the real action.

MLB Opening Day 2025

The first spring training game is set for February 20, with the games coming thick and fast after that. In the grand scheme of things, we don’t tend to learn a lot from spring training, as it is little more than warm up games for a lot of players.

Pitchers will see limited action in these games, but we can get some idea as to how players and teams might start the season, as opposed to how they will perform as a whole.

MLB opening day is March 27th, featuring 14 games. This presents numerous betting opportunities, though navigating them can be challenging for bettors.

Yes, we all have an idea as to who will be challenging for the World Series and which teams will be in for a long, fruitless season, but there is something special about opening day and the surprises that we often see.

MLB opening day predictions

Let’s start by talking about some opening day betting strategies you might want to consider.

• Check the starting pitchers: On opening day in MLB, all teams will pitch their best, but mismatches may still occur, so watch the starting pitchers closely.

• Low Scoring?: Concerning opening day pitchers, scoring may be limited; consider betting the UNDER, particularly for First 5 Innings wagers.

• Weather could be a factor: Despite spring, colder temperatures in some areas may influence weather conditions, leading to potentially lower scoring games.

• Ignore the hype: Several teams will begin the season with significant free agent signings, but chemistry may take time. Consider betting on underdogs against potentially overhyped teams with inflated odds.

• Check out historical data: Not all MLB teams succeed on opening day; historical patterns indicate some struggle while others perform well consistently.

MLB Opening Day 2025 Matchups

Making MLB opening day predictions at this stage of the proceedings is next to impossible, as we simply don’t know who will be starting for each team.

Sure, we can make a very educated guess, but injuries happen in spring training, as do underwhelming performances, all of which can have an impact on where pitchers land in the rotation.

Still, we can look at the full schedule for MLB opening day 2025 and talk about how each team performed last season, so let’s get into that.

Milwaukee Brewers at New York Yankees

We have a couple of division winners from last season meeting up on MLB opening day 2025, with the Yankees trying to bounce back after losing to the Dodgers in the World Series last season.

Baltimore Orioles at Toronto Blue Jays

The Jays just made some news by signing Max Scherzer to a 1-year deal, but whether that proves to be a good move remains to be seen. The Orioles made it into the Wild Card last season and should be good again this year.

Philadelphia Phillies at Washington Nationals

The Phillies ended up winning the NL East in a bit of a canter last season and should be in the mix again. You can’t say the same for the Nationals, who still appear to be in rebuilding mode.

Boston Red Sox at Texas Rangers

Last season, the Rangers proved how difficult it is to win back-to-back championships, as they failed to make it back into the postseason. The Red Sox were a .500 ball team last season and will be looking to improve.

Pittsburgh Pirates at Miami Marlins

Both of these teams finished at the bottom of their respective divisions last season, so the only way is up. The Pirates have started the season strong in each of the last 2 seasons, so they might be a good MLB opening day 25 pick.

San Francisco Giants at Cincinnati Reds

2024 was not the best year for either of these teams, as they both ended the season below .500. In terms of opening day predictions, this one looks like a coin flip.

LA Angels at Chicago White Sox

Once again, we have a pair of teams who finished at the bottom of their respective decisions last season, so you can bet that both will be looking to get out to a winning start.

Cleveland Guardians at Kansas City Royals

This is a big divisional matchup to start the season. The Guardians won the Central Division last season, finishing ahead of the Royals, so KC will be looking to exact some revenge on MLB opening day 2025.

New York Mets at Houston Astros

The Astros are the perfect example of a good team that got off to a slow start, as they were poo to start last season before getting on a roll and winning the division. You would like them to win on opening day against the Mets.

Atlanta Braves at San Diego Padres

The goal for the Braves this season will be to try and avoid the injuries that plague them in 2024. They will have a tough opening day matchup against a very good Padres team.

Minnesota Twins at St. Louis Cardinals

The Twins saw the wheels come off in the closing stages of last season, but they did finish above .500. It was a similar story for the Cardinals, so could either of them become a dark horse in 2025?

Detroit Tigers at LA Dodgers

It’s never ideal to go into MLB opening day on the road against the World Series champions, but that is exactly what the Tigers will need to do when they travel to start the season against the Dodgers.

Chicago Cubs at Arizona Diamondbacks

The Diamondbacks just missed out on a Wild Card spot last season, winning 89 games. The Cubs were a little further off the pace, but this still seems like a pretty evenly matched game.

Athletics Vs Seattle Mariners

The A’s are a team in transition, as they will be playing in Sacramento in 2025 as they wait to move to Las Vegas. They will open on the road against the Seattle Mariners.

MLB Opening Day 2025 In Conclusion

To learn how to bet on MLB Opening Day 2025, it is key to follow spring training games in February and March, focusing on individual performances.

Are them some young players coming through that could potentially make a difference to their team in the regular season? Are there some pitchers who struggle in the preseason, with those woes potentially carrying over?

Identifying hot or cold players aids in making winning MLB opening day predictions. Once starting pitchers are announced, strategies for wagering can be refined.

Julio Rodríguez, Gunnar Henderson, Corbin Carroll and Bobby Witt Jr. all earned their clubs an extra Draft pick over the past 3 seasons.

Here's a list of which players could do the same in 2025: https://t.co/IyaYPlXaX8 pic.twitter.com/srUuPW0pUb

— MLB Pipeline (@MLBPipeline) January 31, 2025

MLB Betting Center

---

Updated MLB Odds | Sportsbook Online

mybookie App Download App

Download Remind me later