NFL Week 16 Odds Overview & Predictions for Each Game

NFL Week 16 is here. Few matchups in Week 16 don’t have playoff implications, which means most teams will be all out to grab victories. Check out NFL Betting Odds, analysis, and free picks for every NFL Week 16 game. 

2021 NFL Regular Season – Week 16 Odds Analysis & Picks

2021 NFL Week 16

• When: Thursday, Dec. 23 – Monday, Dec. 27

San Francisco 49ers -3 ½ vs Tennessee Titans

• When: Thursday, Dec. 23

The Titans have sold out to stop the rush. On Thursday night, they face Jimmy Garoppolo and Deebo Samuel. Expect the 49ers to win this by at least 4. 

NFL Week 16 Pick: San Francisco 49ers

Cleveland Browns vs Green Bay Packers -7

• When: Sunday, Dec. 26

Cleveland is reeling. But even at full strength, the Browns would be a play against. Why? Green Bay is 6-0 ATS at home. The Packers are 5-0 ATS as a favorite. So with a banged up Myles Garrett and the possibility of Nick Mullens starting his second straight, the Browns are an underlay at +7.

NFL Week 16 Pick: Green Bay Packers 

Indianapolis Colts vs Arizona Cardinals pick

• When: Sunday, Dec. 26

The line has gone from Colts +1 ½ to a pick. By kickoff, Indianapolis cold be a -2 to -3 favorite. There’s a reason why NFL handicappers are dumping on Indy.  

NFL Week 16 Pick: Indianapolis Colts

Jacksonville Jaguars vs New York Jets -2 ½

• When: Sunday, Dec. 26

Jacksonville got rid of Urban Meyer and it didn’t mean a thing. The Jaguars are a terrible football team. They have zero leaders and are a flat out bad organization. The Jets appear to be on track. They aren’t good right now, but Zach Wilson has started to play well. J-E-T-S blows out the woeful Jags. 

NFL Week 16 Pick: New York Jets

New York Giants vs Philadelphia Eagles -10

• When: Sunday, Dec. 26

The New York Giants have no passing attack, which means NYG’s strength, the rushing game, plays into an Eagles’ strength, stopping the run. Philadelphia is a well-coached football team that has hit their stride. They’ll dominate the Giants. 

NFL Week 16 Pick: Philadelphia Eagles 

Los Angeles Rams -3 vs Minnesota Vikings

• When: Sunday, Dec. 26

The Rams beat the Seattle Seahawks by 10, but we shouldn’t read too much into it. The Vikings are a better team at home than they are on the road. Minnesota should push LAR in this. Get greedy and back the Vikings on the moneyline if you truly believe, or take the points if you think LAR wins SU. 

NFL Week 16 Pick: Minnesota Vikings 

Detroit Lions vs Atlanta Falcons -6

• When: Sunday, Dec. 26

The Falcons shouldn’t be a 6-point favorite against any opponent. We see this as an opportunity to make a nice profit on the Lions’ moneyline. Detroit wins their second straight. 

NFL Week 16 Pick: Detroit Lions 

Buffalo Bills vs New England Patriots -2 ½ 

• When: Sunday, Dec. 26

The Bills got their offense going against the Panthers. So there is a reason to back Josh Allen and his crew versus the Patriots. But do you really think Bill Belichick will lose 2 in a row? Also, do you think the second loss will be against a team New England owns? Patriots win and cover. 

NFL Week 16 Pick: New England Patriots 

Tampa Bay Buccaneers -10 ½ vs Carolina Panthers

• When: Sunday, Dec. 26

The Bucs placed both Chris Godwin and Leonard Fournette on IR. But although 10 ½ is a lot of points and TB did lose to the Saints in their last, the Panthers have a terrible offense. Carolina can’t move the football against anyone. Still, the Bucs have trouble covering on the road. So we’ll take a shot on the Panthers to keep this closer than the number. 

NFL Week 16 Pick: Carolina Panthers 

Baltimore Ravens vs Cincinnati Bengals -2 ½ 

• When: Sunday, Dec. 26

Baltimore is a decent team. But this is a road matchup against a division rival with a good quarterback, Joe Burrow, and one of the best wide receivers in the league, Ja’Marr Chase. Cincy dominated the Ravens in the first game. The Bengals should win the rematch by at least 6.

NFL Week 16 Pick: Cincinnati Bengals

Los Angeles Chargers -9 ½ vs Houston Texans

• When: Sunday, Dec. 26

The Bolts know they blew a chance to sweep the Kansas City Chiefs in their Week 15 loss. Houston has played decent football in recent weeks, but they shouldn’t keep it close versus the desperate Chargers. 

NFL Week 16 Pick: Los Angeles Chargers 

Chicago Bears vs Seattle Seahawks -6 ½ 

• When: Sunday, Dec. 26

This is a tough game to handicap. The Seahawks lost their Tuesday game versus the Rams. The Bears should have beaten the Vikings in their Monday night loss. Seattle, though, plays with pride. They’ll cover. 

NFL Week 16 Pick: Seattle Seahawks 

Pittsburgh Steelers vs Kansas City Chiefs -7 ½ 

• When: Sunday, Dec. 26

The Chiefs may be without Tyreek Hill and Travis Kelce. They’re almost certain to be without Hill. The Steelers played great in NFL Week 15, rallying to beat the Titans. Expect Pittsburgh to keep this much closer than the spread. 

NFL Week 16 Pick: Pittsburgh Steelers 

Denver Broncos vs Las Vegas Raiders -1

• When: Sunday, Dec. 26

The Broncos defense should contain the Raiders’ rushing attack. Also, Derrick Carr doesn’t always make the best decision. So Denver is the play. 

NFL Week 16 Pick: Denver Broncos 

Washington Football Team vs Dallas Cowboys -10 

• When: Sunday, Dec. 26

Dallas trounced the Commanders in D.C. in the first game. In the rematch, Dallas figures to pour it on big time. The Cowboys are gearing up for the playoffs, which means they dominate on both sides of the ball. 

NFL Week 16 Pick: Dallas Cowboys 

Miami Dolphins vs New Orleans Saints -3

• When: Monday, Dec. 27

Give the Saints a big edge. New Orleans played a masterful game versus the Buccaneers. Now that the Saints are in a position for a wildcard, they should destroy a Miami team that could be missing key players due to coronavirus protocols. 

NFL Week 16 Pick: New Orleans Saints 

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